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Autophagy-regulating miRNAs: potential targets for obesity and related metabolic disorders Journal article
Drug Discovery Today, 2021
Authors:  Zhang,Tian;  Linghu,Ke Gang;  Lou,Ruohan;  Li,Zhengqiu;  Liu,Jingxin;  Li,Rongsong;  Qin,Zheng Hong;  Guo,Bing;  Lin,Ligen
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Sesquiterpene lactone dimers from Artemisia lavandulifolia inhibit interleukin-1β production in macrophages through activating autophagy Journal article
Bioorganic Chemistry, 2020,Volume: 105
Authors:  Wang,Qiaoqiao;  Zhang,Tian;  Ke,Chang Qiang;  Tang,Chunping;  Yao,Sheng;  Lin,Ligen;  Ye,Yang
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Artemisia lavandulifolia  Autophagy  IL-1β  NLRP3  Sesquiterpene lactone dimers  
Pimarane diterpenoids from the seeds of caesalpinia minax as PTP1B inhibitors and insulin sensitizers Journal article
Molecules, 2020,Volume: 25,Issue: 20
Authors:  Xu,Yunshao;  Feng,Zheling;  Zhang,Tian;  Lv,Peng;  Cao,Jun;  Li,Dan;  Peng,Cheng;  Lin,Ligen
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C2C12 myotubes  Caesalpinia minax  Glucose uptake  Pimarane diterpenoids  PTP1B  
Small molecule-driven SIRT3-autophagy-mediated NLRP3 inflammasome inhibition ameliorates inflammatory crosstalk between macrophages and adipocytes Journal article
British Journal of Pharmacology, 2020,Volume: 177,Issue: 20,Page: 4645-4665
Authors:  Zhang,Tian;  Fang,Zhujun;  Linghu,Ke Gang;  Liu,Jingxin;  Gan,Lishe;  Lin,Ligen
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adipocytes  adipose tissue inflammation  autophagy  cycloartane triterpenoid  IL-1β, macrophages  NLRP3 inflammasome  
Sigesbeckia orientalis L. Extract Alleviated the Collagen Type II–Induced Arthritis Through Inhibiting Multi-Target–Mediated Synovial Hyperplasia and Inflammation Journal article
Frontiers in Pharmacology, 2020,Volume: 11
Authors:  Linghu,Ke Gang;  Xiong,Shi Hang;  Zhao,Guan Ding;  Zhang,Tian;  Xiong,Wei;  Zhao,Mingming;  Shen,Xiang Chun;  Xu,Wei;  Bian,Zhaoxiang;  Wang,Yitao;  Yu,Hua
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inflammation  MH7A  rheumatoid arthritis  Sigesbeckia orientalisL  SW982  synovial hyperplasia  
Sigesbeckia glabrescens Makino extract attenuated the collagen-induced arthritis through inhibiting the synovial hyperplasia and inflammation Journal article
Chinese Medicine (United Kingdom), 2020,Volume: 15,Issue: 1
Authors:  Ma,Qiu Shuo;  Linghu,Ke Gang;  Zhang,Tian;  Zhao,Guan Ding;  Xiong,Wei;  Xiong,Shi Hang;  Zhao,Mingming;  Xu,Wei;  Yu,Juan;  Yu,Hua
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Inflammation  Nuclear transcription factor-kappa B  Rheumnnatoid arthritis  Sigesbeckia glabrescens Makino  SW982  Synovial hyperplasia  
Targeted isolation of two disesquiterpenoid macrocephadiolides A and B from: Ainsliaea macrocephala using a molecular networking-based dereplication strategy Journal article
Organic Chemistry Frontiers, 2020,Volume: 7,Issue: 12,Page: 1481-1489
Authors:  Ren,Yong Mei;  Ren,Yong Mei;  Ren,Yong Mei;  Zhou,Shuai Zhen;  Zhang,Tian;  Qian,Meijia;  Zhang,Rui;  Yao,Sheng;  Zhu,Hong;  Tang,Chunping;  Lin,Ligen;  Ye,Yang;  Ye,Yang;  Ye,Yang
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Tricarabrols A-C, three anti-inflammatory sesquiterpene lactone trimers featuring a methylene-tethered linkage from: Carpesium faberi Journal article
Organic Chemistry Frontiers, 2020,Volume: 7,Issue: 11,Page: 1374-1382
Authors:  Yuan,Jie;  Wen,Xuelan;  Ke,Chang Qiang;  Zhang,Tian;  Lin,Ligen;  Yao,Sheng;  Goodpaster,Jason D.;  Tang,Chunping;  Ye,Yang
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SIRT3 acts as a positive autophagy regulator to promote lipid mobilization in adipocytes via activating AMPK Journal article
International Journal of Molecular Sciences, 2020,Volume: 21,Issue: 2
Authors:  Zhang,Tian;  Liu,Jingxin;  Tong,Qiang;  Lin,Ligen
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AMPK  Chaperone-mediated autophagy  Lipid metabolism  Macroautophagy  Sirtuin 3  
Natural constituents from food sources as therapeutic agents for obesity and metabolic diseases targeting adipose tissue inflammation Journal article
Critical Reviews in Food Science and Nutrition, 2020
Authors:  Li,Dan;  Zhang,Tian;  Lu,Jinjian;  Peng,Cheng;  Lin,Ligen
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adipocytes  Adipose tissue inflammation  crosstalk  dietary bioactive nutrients  macrophages  metabolic disease