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Synthesis, biological evaluation and structure-activity relationship of novel dichloroacetophenones targeting pyruvate dehydrogenase kinases with potent anticancer activity Journal article
European Journal of Medicinal Chemistry, 2021,Volume: 214
Authors:  Xu,Biao;  Wang,Zhi Peng;  Liu,Qingwang;  Yang,Xiaohong;  Li,Xuemin;  Huang,Ding;  Qiu,Yanfei;  Tam,Kin Yip;  Zhang,Shao Lin;  He,Yun
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Cancer metabolism  Proliferation  Pyruvate dehydrogenase kinase  Structure-activity relationship  
Recent developments of human monocarboxylate transporter (hMCT) inhibitors as anticancer agents Journal article
Drug Discovery Today, 2021
Authors:  Wu,Puhua;  Zhou,Yan;  Guo,Yizhen;  Zhang,Shao Lin;  Tam,Kin Yip
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Development of dual inhibitors targeting pyruvate dehydrogenase kinases and human lactate dehydrogenase A: High-throughput virtual screening, synthesis and biological validation Journal article
European Journal of Medicinal Chemistry, 2020,Volume: 203
Authors:  Xiang,Sichuan;  Huang,Ding;  He,Qiaolin;  Li,Jie;  Tam,Kin Yip;  Zhang,Shao Lin;  He,Yun
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Cancer metabolism  Cancer proliferation  Dual inhibitor  Lactate dehydrogenase A  Pyruvate dehydrogenase kinase  
Dichloroacetophenones targeting at pyruvate dehydrogenase kinase 1 with improved selectivity and antiproliferative activity: Synthesis and structure-activity relationships Journal article
Bioorganic and Medicinal Chemistry Letters, 2018,Volume: 28,Issue: 21,Page: 3441-3445
Authors:  Zhang,Shao Lin;  Yang,Zheng;  Hu,Xiaohui;  Tam,Kin Yip
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Antiproliferative activity  Dichloroacetophenone  Kinase inhibition  Pyruvate dehydrogenase complex  Pyruvate dehydrogenase kinase  
Synthesis and biological evaluation of (R)-3,3,3-trifluoro-2-hydroxy-2-methylpropionamides as pyruvate dehydrogenase kinase 1 (PDK1) inhibitors to reduce the growth of cancer cells Journal article
European Journal of Pharmaceutical Sciences, 2017,Volume: 110,Page: 87-92
Authors:  Zhang,Shao Lin;  Zhang,Wen;  Yang,Zheng;  Hu,Xiaohui;  Tam,Kin Yip
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Anti-proliferation  Binding affinity  Pyruvate dehydrogenase complex  Pyruvate dehydrogenase kinase  
Phenyl butyrate inhibits pyruvate dehydrogenase kinase 1 and contributes to its anti-cancer effect Journal article
European Journal of Pharmaceutical Sciences, 2017,Volume: 110,Page: 93-100
Authors:  Zhang,Wen;  Zhang,Shao Lin;  Hu,Xiaohui;  Tam,Kin Yip
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Cancer  Phenyl butyrate  Pyruvate dehydrogenase  Pyruvate dehydrogenase kinase 1  Tumor metabolism  
Development of dichloroacetamide pyrimidines as pyruvate dehydrogenase kinase inhibitors to reduce cancer cell growth: Synthesis and biological evaluation Journal article
RSC Advances, 2016,Volume: 6,Issue: 82,Page: 78762-78767
Authors:  Zhang,Shao Lin;  Zhang,Wen;  Xiao,Qingpin;  Yang,Zheng;  Hu,Xiaohui;  Wei,Zhiyi;  Tam,Kin Yip
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Study the interactions between human serum albumin and two antifungal drugs: Fluconazole and its analogue DTP Journal article
Bioorganic and Medicinal Chemistry Letters, 2014,Volume: 24,Issue: 21,Page: 4963-4968
Authors:  Zhang,Shao Lin;  Yao,Huankai;  Wang,Chenyin;  Tam,Kin Y.
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Binding affinity  Fluconazole  Fluorescence spectrum  Human serum albumin  Molecular docking