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Natural products targeting cancer cell dependency Journal article
Journal of Antibiotics, 2021,Volume: 74,Issue: 10,Page: 677-686
Authors:  Shi, Changxiang;  Yang, Eun Ju;  Tao, Shishi;  Ren, Guowen;  Mou, Pui Kei;  Shim, Joong Sup
Favorite |  | TC[WOS]:0 TC[Scopus]:0 | Submit date:2021/12/08
Aurora kinase A, a synthetic lethal target for precision cancer medicine Journal article
Experimental and Molecular Medicine, 2021,Volume: 53,Issue: 5,Page: 835-847
Authors:  Mou, Pui Kei;  Yang, Eun Ju;  Shi, Changxiang;  Ren, Guowen;  Tao, Shishi;  Shim, Joong Sup
Favorite |  | TC[WOS]:1 TC[Scopus]:1 | Submit date:2021/12/07
Molecular landscape and subtype-specific therapeutic response of nasopharyngeal carcinoma revealed by integrative pharmacogenomics Journal article
Nature Communications, 2021,Volume: 12,Issue: 1
Authors:  Ding, Ren Bo;  Chen, Ping;  Rajendran, Barani Kumar;  Lyu, Xueying;  Wang, Haitao;  Bao, Jiaolin;  Zeng, Jianming;  Hao, Wenhui;  Sun, Heng;  Wong, Ada Hang Heng;  Valecha, Monica Vishnu;  Yang, Eun Ju;  Su, Sek Man;  Choi, Tak Kan;  Liu, Shuiming;  Chan, Kin Iong;  Yang, Ling Lin;  Wu, Jingbo;  Miao, Kai;  Chen, Qiang;  Shim, Joong Sup;  Xu, Xiaoling;  Deng, Chu Xia
Favorite |  | TC[WOS]:2 TC[Scopus]:2 | Submit date:2021/11/30
Bromodomain and extra-terminal motif (BET) inhibition is synthetic lethal with loss of SMAD4 in colorectal cancer cells via restoring the loss of MYC repression Journal article
Oncogene, 2021,Volume: 40,Issue: 5,Page: 937-950
Authors:  Shi,Changxiang;  Yang,Eun Ju;  Liu,Yifan;  Mou,Pui Kei;  Ren,Guowen;  Shim,Joong Sup
Favorite |  | TC[WOS]:2 TC[Scopus]:2 | Submit date:2021/03/04
Synthetic lethality of RB1 and aurora A is driven by stathmin-mediated disruption of microtubule dynamics Journal article
Nature Communications, 2020,Volume: 11,Issue: 1
Authors:  Lyu,Junfang;  Yang,Eun Ju;  Zhang,Baoyuan;  Wu,Changjie;  Pardeshi,Lakhansing;  Shi,Changxiang;  Mou,Pui Kei;  Liu,Yifan;  Tan,Kaeling;  Shim,Joong Sup
Favorite |  | TC[WOS]:6 TC[Scopus]:6 | Submit date:2021/03/04
Class I histone deacetylase inhibition is synthetic lethal with BRCA1 deficiency in breast cancer cells Journal article
Acta Pharmaceutica Sinica B, 2020,Volume: 10,Issue: 4,Page: 615-627
Authors:  Zhang,Baoyuan;  Lyu,Junfang;  Yang,Eun Ju;  Liu,Yifan;  Wu,Changjie;  Pardeshi,Lakhansing;  Tan,Kaeling;  Chen,Qiang;  Xu,Xiaoling;  Deng,Chu Xia;  Shim,Joong Sup
Favorite |  | TC[WOS]:14 TC[Scopus]:15 | Submit date:2020/09/16
Brca1  Breast Cancer  Dna Damage  Hdac  Histone Deacetylase  Reactive Oxygen Species  Synthetic Lethality  
Histone acetyltransferase (HAT) P300/CBP inhibitors induce synthetic lethality in pten-deficient colorectal cancer cells through destabilizing AKT Journal article
International Journal of Biological Sciences, 2020,Volume: 16,Issue: 11,Page: 1774-1784
Authors:  Liu,Yifan;  Yang,Eun Ju;  Shi,Changxiang;  Mou,Pui Kei;  Zhang,Baoyuan;  Wu,Changjie;  Lyu,Junfang;  Shim,Joong Sup
Favorite |  | TC[WOS]:5 TC[Scopus]:4 | Submit date:2021/03/04
AKT  Anacardic acid  Histone acetyltransferases  Hsp70  PTEN  Synthetic lethality  
Targeting AURKA-CDC25C axis to induce synthetic lethality in ARID1A-deficient colorectal cancer cells Journal article
NATURE COMMUNICATIONS, 2018,Volume: 9
Authors:  Wu, Changjie;  Lyu, Junfang;  Yang, Eun Ju;  Liu, Yifan;  Zhang, Baoyuan;  Shim, Joong Sup
Favorite |  | TC[WOS]:41 TC[Scopus]:39 | Submit date:2018/10/30
BRCA1 deficiency sensitizes breast cancer cells to bromodomain and extra-terminal domain (BET) inhibition Journal article
Oncogene, 2018,Issue: 37,Page: 6341–6356
Authors:  Baoyuan Zhang;  Junfang Lyu;  Yifan Liu;  Changjie Wu;  Eun Ju Yang;  Lakhansing Pardeshi;  Kaeling Tan;  Koon Ho Wong;  Qiang Chen;  Xiaoling Xu;  Chu-Xia Deng;  Joong Sup Shim
Favorite |  | TC[WOS]:7 TC[Scopus]:7 | Submit date:2018/12/17
Astemizole inhibits mTOR signaling and angiogenesis by blocking cholesterol trafficking Journal article
International Journal of Biological Sciences, 2018,Volume: 14,Issue: 10,Page: 1175-1185
Authors:  Lyu,Junfang;  Yang,Eun Ju;  Head,Sarah A.;  Ai,Nana;  Zhang,Baoyuan;  Wu,Changjie;  Li,Ruo Jing;  Liu,Yifan;  Chakravarty,Harapriya;  Zhang,Shaolin;  Tam,Kin Yip;  Dang,Yongjun;  Kwon,Ho Jeong;  Ge,Wei;  Liu,Jun O.;  Shim,Joong Sup
Favorite |  | TC[WOS]:7 TC[Scopus]:5 | Submit date:2021/03/02
Angiogenesis  Astemizole  Cholesterol trafficking  mTOR  NPC1