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Bromodomain and extra-terminal motif (BET) inhibition is synthetic lethal with loss of SMAD4 in colorectal cancer cells via restoring the loss of MYC repression Journal article
Oncogene, 2021,Volume: 40,Issue: 5,Page: 937-950
Authors:  Shi,Changxiang;  Yang,Eun Ju;  Liu,Yifan;  Mou,Pui Kei;  Ren,Guowen;  Shim,Joong Sup
Favorite |  | TC[WOS]:0 TC[Scopus]:0 | Submit date:2021/03/04
Synthetic lethality of RB1 and aurora A is driven by stathmin-mediated disruption of microtubule dynamics Journal article
Nature Communications, 2020,Volume: 11,Issue: 1
Authors:  Lyu,Junfang;  Yang,Eun Ju;  Zhang,Baoyuan;  Wu,Changjie;  Pardeshi,Lakhansing;  Shi,Changxiang;  Mou,Pui Kei;  Liu,Yifan;  Tan,Kaeling;  Shim,Joong Sup
Favorite |  | TC[WOS]:1 TC[Scopus]:1 | Submit date:2021/03/04
Class I histone deacetylase inhibition is synthetic lethal with BRCA1 deficiency in breast cancer cells Journal article
Acta Pharmaceutica Sinica B, 2020,Volume: 10,Issue: 4,Page: 615-627
Authors:  Zhang,Baoyuan;  Lyu,Junfang;  Yang,Eun Ju;  Liu,Yifan;  Wu,Changjie;  Pardeshi,Lakhansing;  Tan,Kaeling;  Chen,Qiang;  Xu,Xiaoling;  Deng,Chu Xia;  Shim,Joong Sup
Favorite |  | TC[WOS]:4 TC[Scopus]:7 | Submit date:2020/09/16
Brca1  Breast Cancer  Dna Damage  Hdac  Histone Deacetylase  Reactive Oxygen Species  Synthetic Lethality  
Histone acetyltransferase (HAT) P300/CBP inhibitors induce synthetic lethality in pten-deficient colorectal cancer cells through destabilizing AKT Journal article
International Journal of Biological Sciences, 2020,Volume: 16,Issue: 11,Page: 1774-1784
Authors:  Liu,Yifan;  Yang,Eun Ju;  Shi,Changxiang;  Mou,Pui Kei;  Zhang,Baoyuan;  Wu,Changjie;  Lyu,Junfang;  Shim,Joong Sup
Favorite |  | TC[WOS]:2 TC[Scopus]:2 | Submit date:2021/03/04
AKT  Anacardic acid  Histone acetyltransferases  Hsp70  PTEN  Synthetic lethality  
Targeting AURKA-CDC25C axis to induce synthetic lethality in ARID1A-deficient colorectal cancer cells Journal article
NATURE COMMUNICATIONS, 2018,Volume: 9
Authors:  Wu, Changjie;  Lyu, Junfang;  Yang, Eun Ju;  Liu, Yifan;  Zhang, Baoyuan;  Shim, Joong Sup
Favorite |  | TC[WOS]:27 TC[Scopus]:24 | Submit date:2018/10/30
BRCA1 deficiency sensitizes breast cancer cells to bromodomain and extra-terminal domain (BET) inhibition Journal article
Oncogene, 2018,Issue: 37,Page: 6341–6356
Authors:  Baoyuan Zhang;  Junfang Lyu;  Yifan Liu;  Changjie Wu;  Eun Ju Yang;  Lakhansing Pardeshi;  Kaeling Tan;  Koon Ho Wong;  Qiang Chen;  Xiaoling Xu;  Chu-Xia Deng;  Joong Sup Shim
Favorite |  | TC[WOS]:6 TC[Scopus]:6 | Submit date:2018/12/17
Astemizole inhibits mTOR signaling and angiogenesis by blocking cholesterol trafficking Journal article
International Journal of Biological Sciences, 2018,Volume: 14,Issue: 10,Page: 1175-1185
Authors:  Lyu,Junfang;  Yang,Eun Ju;  Head,Sarah A.;  Ai,Nana;  Zhang,Baoyuan;  Wu,Changjie;  Li,Ruo Jing;  Liu,Yifan;  Chakravarty,Harapriya;  Zhang,Shaolin;  Tam,Kin Yip;  Dang,Yongjun;  Kwon,Ho Jeong;  Ge,Wei;  Liu,Jun O.;  Shim,Joong Sup
Favorite |  | TC[WOS]:3 TC[Scopus]:3 | Submit date:2021/03/02
Angiogenesis  Astemizole  Cholesterol trafficking  mTOR  NPC1  
Astemizole Inhibits mTOR Signaling and Angiogenesis by Blocking Cholesterol Trafficking Journal article
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES, 2018,Volume: 14,Issue: 10,Page: 1175-1185
Authors:  Lyu, Junfang;  Yang, Eun Ju;  Head, Sarah A.;  Ai, Nana;  Zhang, Baoyuan;  Wu, Changjie;  Li, Ruo-Jing;  Liu, Yifan;  Chakravarty, Harapriya;  Zhang, Shaolin;  Tam, Kin Yip;  Dang, Yongjun;  Kwon, Ho Jeong;  Gel, Wei;  Liu, Jun O.;  Shim, Joong Sup
Favorite |  | TC[WOS]:3 TC[Scopus]:3 | Submit date:2018/10/30
Cholesterol Trafficking  Angiogenesis  Astemizole  Npc1  Mtor  
PTEN deficiency confers colorectal cancer cell resistance to dual inhibitors of FLT3 and aurora kinase A Journal article
CANCER LETTERS, 2018,Volume: 436,Page: 28-37
Authors:  Yifan Liu;  Eun Ju Yang;  Baoyuan Zhang;  Zhengqiang Miao;  Changjie Wu;  Junfang Lyu;  Kaeling Tan;  Terence Chuen Wai Poon;  Joong Sup Shim
Favorite |  | TC[WOS]:7 TC[Scopus]:6 | Submit date:2018/10/30
Akt  Kw2449  Synthetic Lethality  Aurka  Drug Combination  
Pharmacological blockade of cholesterol trafficking by cepharanthine in endothelial cells suppresses angiogenesis and tumor growth Journal article
CANCER LETTERS, 2017,Volume: 409,Page: 91-103
Authors:  Lyu, Junfang;  Yang, Eun Ju;  Head, Sarah A.;  Ai, Nana;  Zhang, Baoyuan;  Wu, Changjie;  Li, Ruo-Jing;  Liu, Yifan;  Yang, Chen;  Dang, Yongjun;  Kwon, Ho Jeong;  Ge, Wei;  Liu, Jun O.;  Shim, Joong Sup
Favorite |  | TC[WOS]:25 TC[Scopus]:25 | Submit date:2018/10/30
Cholesterol Trafficking  Angiogenesis  Tumor  Lysosome  Cepharanthine