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Co-option of an extracellular protease for transcriptional control of nutrient degradation in the fungus Aspergillus nidulans Journal article
Communications Biology, 2021,Volume: 4,Issue: 1
Authors:  Li, Ang;  Parsania, Chirag;  Tan, Kaeling;  Todd, Richard B.;  Wong, Koon Ho
Favorite |  | TC[WOS]:0 TC[Scopus]:0 | Submit date:2022/01/14
Transcription in fungal conidia before dormancy produces phenotypically variable conidia that maximize survival in different environments Journal article
Nature Microbiology, 2021,Volume: 6,Issue: 8,Page: 1066-1081
Authors:  Wang, Fang;  Sethiya, Pooja;  Hu, Xiaohui;  Guo, Shuhui;  Chen, Yingying;  Li, Ang;  Tan, Kaeling;  Wong, Koon Ho
Favorite |  | TC[WOS]:3 TC[Scopus]:5 | Submit date:2021/12/08
RUVBL1/2 Complex Regulates Pro-Inflammatory Responses in Macrophages via Regulating Histone H3K4 Trimethylation Journal article
Frontiers in Immunology, 2021,Volume: 12
Authors:  Zhang, Rui;  Cheung, Chris Y.;  Seo, Sang Uk;  Liu, Hang;  Pardeshi, Lakhansing;  Wong, Koon Ho;  Chow, Larry M.C.;  Chau, Mary P.;  Wang, Yixiang;  Lee, Ah Ra;  Kwon, Woon Yong;  Chen, Sheng;  Chan, Bill Kwan wai;  Wong, Kenneth;  Choy, Richard K.W.;  Ko, Ben C.B.
Favorite |  | TC[WOS]:0 TC[Scopus]:0 | Submit date:2021/12/08
epigenetic modulation  H3K4 trimethylation  macrophages  pro-inflammatory  RUVBL1/2  
Dissecting the heterogeneity and tumorigenesis of BRCA1 deficient mammary tumors via single cell RNA sequencing Journal article
Theranostics, 2021,Volume: 11,Issue: 20,Page: 9967-9987
Authors:  Sun, Heng;  Zeng, Jianming;  Miao, Zhengqiang;  Lei, Kuan Cheok;  Huang, Chen;  Hu, Lingling;  Su, Sek Man;  Chan, Un In;  Miao, Kai;  Zhang, Xu;  Zhang, Aiping;  Guo, Sen;  Chen, Si;  Meng, Ya;  Deng, Min;  Hao, Wenhui;  Lei, Haipeng;  Lin, Ying;  Yang, Zhonglin;  Tang, Dongjiang;  Wong, Koon Ho;  Zhang, Xiaohua Douglas;  Xu, Xiaoling;  Deng, Chu Xia
Favorite |  | TC[WOS]:0 TC[Scopus]:0 | Submit date:2021/11/30
Brca1/BRCA1  Mammary tumor  Mrc2  Single cell RNA-seq  Tumor heterogeneity  
Cisplatin prevents breast cancer metastasis through blocking early EMT and retards cancer growth together with paclitaxel Journal article
Theranostics, 2021,Volume: 11,Issue: 5,Page: 2442-2459
Authors:  Wang,Haitao;  Guo,Sen;  Kim,Seung Jin;  Shao,Fangyuan;  Kei Ho,Joshua Wing;  Wong,Kuan Un;  Miao,Zhengqiang;  Hao,Dapeng;  Zhao,Ming;  Xu,Jun;  Zeng,Jianming;  Wong,Koon Ho;  Di,Lijun;  Wong,Ada Hang Heng;  Xu,Xiaoling;  Deng,Chu Xia
Favorite |  | TC[WOS]:4 TC[Scopus]:3 | Submit date:2021/03/02
Cisplatin  Metastasis  Neoadjuvant Therapy  Paclitaxel  Tgfβ  
Carbon catabolite repression in filamentous fungi is regulated by phosphorylation of the transcription factor crea Journal article
mBio, 2021,Volume: 12,Issue: 1,Page: 1-21
Authors:  de Assis, Leandro José;  Silva, Lilian Pereira;  Bayram, Ozgur;  Dowling, Paul;  Kniemeyer, Olaf;  Krüger, Thomas;  Brakhage, Axel A.;  Chen, Yingying;  Dong, Liguo;  Tan, Kaeling;  Wong, Koon Ho;  Ries, Laure N.A.;  Goldman, Gustavo H.
Favorite |  | TC[WOS]:6 TC[Scopus]:6 | Submit date:2021/12/07
Aspergillus Nidulans  Biofuels  Carbon Catabolite Repression  Crea  Xylanase  
Characterization of BRCA1-deficient premalignant tissues and cancers identifies Plekha5 as a tumor metastasis suppressor Journal article
Nature Communications, 2020,Volume: 11,Issue: 1
Authors:  Liu,Jianlin;  Adhav,Ragini;  Miao,Kai;  Su,Sek Man;  Mo,Lihua;  Chan,Un In;  Zhang,Xin;  Xu,Jun;  Li,Jianjie;  Shu,Xiaodong;  Zeng,Jianming;  Zhang,Xu;  Lyu,Xueying;  Pardeshi,Lakhansing;  Tan,Kaeling;  Sun,Heng;  Wong,Koon Ho;  Deng,Chuxia;  Xu,Xiaoling
Favorite |  | TC[WOS]:9 TC[Scopus]:10 | Submit date:2021/03/02
NOTCH1 activation compensates BRCA1 deficiency and promotes triple-negative breast cancer formation Journal article
Nature Communications, 2020,Volume: 11,Issue: 1
Authors:  Miao,Kai;  Lei,Josh Haipeng;  Valecha,Monica Vishnu;  Zhang,Aiping;  Xu,Jun;  Wang,Lijian;  Lyu,Xueying;  Chen,Si;  Miao,Zhengqiang;  Zhang,Xin;  Su,Sek Man;  Shao,Fangyuan;  Rajendran,Barani Kumar;  Bao,Jiaolin;  Zeng,Jianming;  Sun,Heng;  Chen,Ping;  Tan,Kaeling;  Chen,Qiang;  Wong,Koon Ho;  Xu,Xiaoling;  Deng,Chu Xia
Favorite |  | TC[WOS]:15 TC[Scopus]:14 | Submit date:2020/09/16
A Three-Way Combinatorial CRISPR Screen for Analyzing Interactions among Druggable Targets Journal article
Cell Reports, 2020,Volume: 32,Issue: 6
Authors:  Zhou,Peng;  Chan,Becky K.C.;  Wan,Yuk Kei;  Yuen,Chaya T.L.;  Choi,Gigi C.G.;  Li,Xinran;  Tong,Cindy S.W.;  Zhong,Sophia S.W.;  Sun,Jieran;  Bao,Yufan;  Mak,Silvia Y.L.;  Chow,Maggie Z.Y.;  Khaw,Jien Vei;  Leung,Suet Yi;  Zheng,Zongli;  Cheung,Lydia W.T.;  Tan,Kaeling;  Wong,Koon Ho;  Chan,H. Y.Edwin;  Wong,Alan S.L.
Favorite |  | TC[WOS]:4 TC[Scopus]:7 | Submit date:2021/03/04
Cancer  Combigem  Combination Therapy  Combinatorial Genetics  Crispr  Drug Interaction  Genetic Interaction  High-throughput Screening  Neurodegeneration  Parkinson's Disease  
Aspergillus fumigatus Transcription Factors Involved in the Caspofungin Paradoxical Effect Journal article
mBio, 2020,Volume: 11,Issue: 3
Authors:  Valero,Clara;  Colabardini,Ana Cristina;  Chiaratto,Jéssica;  Pardeshi,Lakhansing;  de Castro,Patrícia Alves;  Filho,Jaire Alves Ferreira;  Silva,Lilian Pereira;  Rocha,Marina Campos;  Malavazi,Iran;  Costa,Jonas Henrique;  Fill,Taícia;  Barros,Mário Henrique;  Wong,Sarah Sze Wah;  Aimanianda,Vishukumar;  Wong,Koon Ho;  Goldman,Gustavo H.
Favorite |  | TC[WOS]:8 TC[Scopus]:9 | Submit date:2021/03/04
Aspergillus Fumigatus  Calcium  Caspofungin  Cell Wall  Transcription Factors  Mitochondria