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Transcription in fungal conidia before dormancy produces phenotypically variable conidia that maximize survival in different environments Journal article
Nature Microbiology, 2021,Volume: 6,Issue: 8,Page: 1066-1081
Authors:  Wang, Fang;  Sethiya, Pooja;  Hu, Xiaohui;  Guo, Shuhui;  Chen, Yingying;  Li, Ang;  Tan, Kaeling;  Wong, Koon Ho
Favorite |  | TC[WOS]:0 TC[Scopus]:3 | Submit date:2021/12/08
RUVBL1/2 Complex Regulates Pro-Inflammatory Responses in Macrophages via Regulating Histone H3K4 Trimethylation Journal article
Frontiers in Immunology, 2021,Volume: 12
Authors:  Zhang, Rui;  Cheung, Chris Y.;  Seo, Sang Uk;  Liu, Hang;  Pardeshi, Lakhansing;  Wong, Koon Ho;  Chow, Larry M.C.;  Chau, Mary P.;  Wang, Yixiang;  Lee, Ah Ra;  Kwon, Woon Yong;  Chen, Sheng;  Chan, Bill Kwan wai;  Wong, Kenneth;  Choy, Richard K.W.;  Ko, Ben C.B.
Favorite |  | TC[WOS]:0 TC[Scopus]:0 | Submit date:2021/12/08
epigenetic modulation  H3K4 trimethylation  macrophages  pro-inflammatory  RUVBL1/2  
Cisplatin prevents breast cancer metastasis through blocking early EMT and retards cancer growth together with paclitaxel Journal article
Theranostics, 2021,Volume: 11,Issue: 5,Page: 2442-2459
Authors:  Wang,Haitao;  Guo,Sen;  Kim,Seung Jin;  Shao,Fangyuan;  Kei Ho,Joshua Wing;  Wong,Kuan Un;  Miao,Zhengqiang;  Hao,Dapeng;  Zhao,Ming;  Xu,Jun;  Zeng,Jianming;  Wong,Koon Ho;  Di,Lijun;  Wong,Ada Hang Heng;  Xu,Xiaoling;  Deng,Chu Xia
Favorite |  | TC[WOS]:3 TC[Scopus]:3 | Submit date:2021/03/02
Cisplatin  Metastasis  Neoadjuvant Therapy  Paclitaxel  Tgfβ  
Dissecting the heterogeneity and tumorigenesis of BRCA1 deficient mammary tumors via single cell RNA sequencing Journal article
Theranostics, 2021,Volume: 11,Issue: 20,Page: 9967-9987
Authors:  Sun, Heng;  Zeng, Jianming;  Miao, Zhengqiang;  Lei, Kuan Cheok;  Huang, Chen;  Hu, Lingling;  Su, Sek Man;  Chan, Un In;  Miao, Kai;  Zhang, Xu;  Zhang, Aiping;  Guo, Sen;  Chen, Si;  Meng, Ya;  Deng, Min;  Hao, Wenhui;  Lei, Haipeng;  Lin, Ying;  Yang, Zhonglin;  Tang, Dongjiang;  Wong, Koon Ho;  Zhang, Xiaohua Douglas;  Xu, Xiaoling;  Deng, Chu Xia
Favorite |  | TC[WOS]:0 TC[Scopus]:0 | Submit date:2021/11/30
Brca1/BRCA1  Mammary tumor  Mrc2  Single cell RNA-seq  Tumor heterogeneity  
Carbon catabolite repression in filamentous fungi is regulated by phosphorylation of the transcription factor crea Journal article
mBio, 2021,Volume: 12,Issue: 1,Page: 1-21
Authors:  de Assis, Leandro José;  Silva, Lilian Pereira;  Bayram, Ozgur;  Dowling, Paul;  Kniemeyer, Olaf;  Krüger, Thomas;  Brakhage, Axel A.;  Chen, Yingying;  Dong, Liguo;  Tan, Kaeling;  Wong, Koon Ho;  Ries, Laure N.A.;  Goldman, Gustavo H.
Favorite |  | TC[WOS]:0 TC[Scopus]:6 | Submit date:2021/12/07
Aspergillus nidulans  Biofuels  Carbon catabolite repression  CreA  Xylanase  
Characterization of BRCA1-deficient premalignant tissues and cancers identifies Plekha5 as a tumor metastasis suppressor Journal article
Nature Communications, 2020,Volume: 11,Issue: 1
Authors:  Liu,Jianlin;  Adhav,Ragini;  Miao,Kai;  Su,Sek Man;  Mo,Lihua;  Chan,Un In;  Zhang,Xin;  Xu,Jun;  Li,Jianjie;  Shu,Xiaodong;  Zeng,Jianming;  Zhang,Xu;  Lyu,Xueying;  Pardeshi,Lakhansing;  Tan,Kaeling;  Sun,Heng;  Wong,Koon Ho;  Deng,Chuxia;  Xu,Xiaoling
Favorite |  | TC[WOS]:8 TC[Scopus]:8 | Submit date:2021/03/02
NOTCH1 activation compensates BRCA1 deficiency and promotes triple-negative breast cancer formation Journal article
Nature Communications, 2020,Volume: 11,Issue: 1
Authors:  Miao,Kai;  Lei,Josh Haipeng;  Valecha,Monica Vishnu;  Zhang,Aiping;  Xu,Jun;  Wang,Lijian;  Lyu,Xueying;  Chen,Si;  Miao,Zhengqiang;  Zhang,Xin;  Su,Sek Man;  Shao,Fangyuan;  Rajendran,Barani Kumar;  Bao,Jiaolin;  Zeng,Jianming;  Sun,Heng;  Chen,Ping;  Tan,Kaeling;  Chen,Qiang;  Wong,Koon Ho;  Xu,Xiaoling;  Deng,Chu Xia
Favorite |  | TC[WOS]:11 TC[Scopus]:11 | Submit date:2020/09/16
A Three-Way Combinatorial CRISPR Screen for Analyzing Interactions among Druggable Targets Journal article
Cell Reports, 2020,Volume: 32,Issue: 6
Authors:  Zhou,Peng;  Chan,Becky K.C.;  Wan,Yuk Kei;  Yuen,Chaya T.L.;  Choi,Gigi C.G.;  Li,Xinran;  Tong,Cindy S.W.;  Zhong,Sophia S.W.;  Sun,Jieran;  Bao,Yufan;  Mak,Silvia Y.L.;  Chow,Maggie Z.Y.;  Khaw,Jien Vei;  Leung,Suet Yi;  Zheng,Zongli;  Cheung,Lydia W.T.;  Tan,Kaeling;  Wong,Koon Ho;  Chan,H. Y.Edwin;  Wong,Alan S.L.
Favorite |  | TC[WOS]:3 TC[Scopus]:6 | Submit date:2021/03/04
Cancer  Combigem  Combination Therapy  Combinatorial Genetics  Crispr  Drug Interaction  Genetic Interaction  High-throughput Screening  Neurodegeneration  Parkinson's Disease  
Deep-AmPEP30: Improve Short Antimicrobial Peptides Prediction with Deep Learning Journal article
Molecular Therapy - Nucleic Acids, 2020,Volume: 20,Page: 882-894
Authors:  Yan,Jielu;  Bhadra,Pratiti;  Li,Ang;  Sethiya,Pooja;  Qin,Longguang;  Tai,Hio Kuan;  Wong,Koon Ho;  Siu,Shirley W.I.
Favorite |  | TC[WOS]:24 TC[Scopus]:27 | Submit date:2021/03/04
AmPEP  ampicillin  antimicrobial peptide  AxPEP  Candida glabrata  convolutional neural network  drug discovery  machine learning  reduced amino acid composition  
Aspergillus fumigatus transcription factors involved in the caspofungin paradoxical effect Journal article
mBio, 2020,Volume: 11,Issue: 3,Page: 1-22
Authors:  Valero,Clara;  Colabardini,Ana Cristina;  Chiaratto,Jéssica;  Pardeshi,Lakhansing;  de Castro,Patrícia Alves;  Filho,Jaire Alves Ferreira;  Silva,Lilian Pereira;  Rocha,Marina Campos;  Malavazi,Iran;  Costa,Jonas Henrique;  Fill,Taícia;  Barros,Mário Henrique;  Wong,Sarah Sze Wah;  Aimanianda,Vishukumar;  Wong,Koon Ho;  Goldman,Gustavo H.
Favorite |  | TC[WOS]:6 TC[Scopus]:8 | Submit date:2021/03/04
Aspergillus fumigatus  Calcium  Caspofungin  Cell wall  Mitochondria  Transcription factors