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Highly diversified core promoters in the human genome and their effects on gene expression and disease predisposition Journal article
BMC Genomics, 2020,Volume: 21,Issue: 1
Authors:  Gupta,Hemant;  Chandratre,Khyati;  Sinha,Siddharth;  Huang,Teng;  Wu,Xiaobing;  Cui,Jian;  Zhang,Michael Q.;  Wang,San Ming
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1000 genomes  Core promoter  eQTL  Exome  GWAS  Variation  
Combining Ramachandran plot and molecular dynamics simulation for structural-based variant classification: Using TP53 variants as model Journal article
Computational and Structural Biotechnology Journal, 2020,Volume: 18,Page: 4033-4039
Authors:  Tam,Benjamin;  Sinha,Siddharth;  Wang,San Ming
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Molecular Dynamic Simulation  Pathogenic  Protein structure  Ramachandran plot  TP53  Variant of Uncertain Significance  
Variants of DNA mismatch repair genes derived from 33,998 Chinese individuals with and without cancer reveal their highly ethnic-specific nature Journal article
European Journal of Cancer, 2020,Volume: 125,Page: 12-21
Authors:  Zhang,Li;  Bhaskaran,Shanmuga Priya;  Huang,Teng;  Dong,Hui;  Chandratre,Khyati;  Wu,Xiaobing;  Qin,Zixin;  Wang,Xiaoyu;  Cao,Wenming;  Chen,Tianhui;  Lynch,Henry;  Wang,San Ming
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Cancer  Chinese  Classification  Ethnicity  MMR genes  Mutation  
Classification of VUS and unclassified variants in BRCA1 BRCT repeats by molecular dynamics simulation Journal article
Computational and Structural Biotechnology Journal, 2020,Volume: 18,Page: 723-736
Authors:  Sinha,Siddharth;  Wang,San Ming
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BRCA1  BRCT  Molecular dynamics simulation  PCA  Unclassified variants  VUS  
Prevalence of BRCA1 / BRCA2 pathogenic variation in Chinese Han population Journal article
Journal of Medical Genetics, 2020
Authors:  Dong,Hui;  Chandratre,Khyati;  Qin,Yue;  Zhang,Jing;  Tian,Xiaoqing;  Rong,Ce;  Wang,Ning;  Guo,Maoni;  Zhao,Guoping;  Wang,San Ming
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cancer: breast  genetics  molecular genetics  oncology  prevention  
Coupled genome-wide DNA methylation and transcription analysis identified rich biomarkers and drug targets in triple-negative breast cancer Journal article
Cancers, 2019,Volume: 11,Issue: 11
Authors:  Guo,Maoni;  Sinha,Siddharth;  Wang,San Ming
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DNA methylation  Gene expression  Therapeutic targets  TNBC  
Germline variation in BRCA1/2 is highly ethnic-specific: Evidence from over 30,000 Chinese hereditary breast and ovarian cancer patients Journal article
International Journal of Cancer, 2019,Volume: 145,Issue: 4,Page: 962-973
Authors:  Bhaskaran,Shanmuga Priya;  Chandratre,Khyati;  Gupta,Hemant;  Zhang,Li;  Wang,Xiaoyu;  Cui,Jian;  Kim,Yeong C.;  Sinha,Siddharth;  Jiang,Luhan;  Lu,Boya;  Wu,Xiaobing;  Qin,Zixin;  Huang,Teng;  Wang,San Ming
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BRCA1  BRCA2  breast cancer  Chinese  ethnic-specific  mutation  population  
Common genetic variants contribute to incomplete penetrance: evidence from cancer-free BRCA1 mutation carriers Journal article
European Journal of Cancer, 2019,Volume: 107,Page: 68-78
Authors:  Downs,Bradley;  Sherman,Simon;  Cui,Jian;  Kim,Yeong C.;  Snyder,Carrie;  Christensen,Maria;  Luo,Jiangtao;  Lynch,Henry;  Wang,San Ming
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BRCA1  Breast cancer  Cancer resistance  Exome  Variation  
Ccdc3: A new P63 target involved in regulation of liver lipid metabolism Journal article
Scientific Reports, 2017,Volume: 7,Issue: 1
Authors:  Liao,Wenjuan;  Liu,Hongbing;  Zhang,Yiwei;  Jung,Ji Hoon;  Chen,Jiaxiang;  Su,Xiaohua;  Kim,Yeong C.;  Flores,Elsa R.;  Wang,San Ming;  Czarny-Ratajczak,Malwina;  Li,Wen;  Zeng,Shelya X.;  Lu,Hua
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