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A 7-methoxybicoumarin derivative selectively inhibits BRD4 BD2 for anti-melanoma therapy Journal article
International Journal of Biological Macromolecules, 2020,Volume: 164,Page: 3204-3220
Authors:  Yang,Guan Jun;  Wang,Wanhe;  Lei,Pui Man;  Leung,Chung Hang;  Ma,Dik Lung
Favorite |  | TC[WOS]:0 TC[Scopus]:0 | Submit date:2021/03/01
BRD4  Bromodomain domain  Cell metastasis and invasion  Histone acetylation  Melanoma  Protein–protein interaction  Virtual screening  
Mimicking strategy for protein-protein interaction inhibitor discovery by virtual screening Journal article
Molecules, 2019,Volume: 24,Issue: 24
Authors:  Wu,Ke Jia;  Lei,Pui Man;  Liu,Hao;  Wu,Chun;  Leung,Chung Hang;  Ma,Dik Lung
Favorite |  | TC[WOS]:5 TC[Scopus]:5 | Submit date:2021/03/01
Drug discovery  Mimetics  Protein-protein interactions  Virtual screening  
Emerging Screening Approaches in the Development of Nrf2-Keap1 Protein-Protein Interaction Inhibitors Journal article
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2019,Volume: 20,Issue: 18
Authors:  Leung, CH;  Zhang, JT;  Yang, GJ;  Liu, H;  Han, QB;  Ma, DL
Favorite |  | TC[WOS]:15 TC[Scopus]:14 | Submit date:2020/03/23
Virtual Screening  Keap1-nrf2  Protein-protein Interaction  Inhibitors  Oxidative Stress  
Structure-Based Discovery of a Selective KDM5A Inhibitor that Exhibits Anti-Cancer Activity via Inducing Cell Cycle Arrest and Senescence in Breast Cancer Cell Lines Journal article
CANCERS, 2019,Volume: 11,Issue: 1
Authors:  Yang, GJ;  Ko, CN;  Zhong, HJ;  Leung, CH;  Ma, DL
Favorite |  | TC[WOS]:13 TC[Scopus]:10 | Submit date:2020/03/24
Cell Cycle Arrest  Kdm5a  Jumonji Domain  Histone Demethylation  Protein-protein Interaction  Virtual Screening  Breast Cancer  Cell Senescence  
Chaos-embedded particle swarm optimization approach for protein-ligand docking and virtual screening Journal article
JOURNAL OF CHEMINFORMATICS, 2018,Volume: 10
Authors:  Tai, Hio Kuan;  Jusoh, Siti Azma;  Siu, Shirley W. I.
Favorite |  | TC[WOS]:5 TC[Scopus]:7 | Submit date:2019/01/17
Docking  Virtual screening  PSOVina  Autodock Vina  Chaotic maps  Singer map  Sinusoidal map  
TNF receptor type II as an emerging drug target for the treatment of cancer, autoimmune diseases, and graft-versus-host disease: Current perspectives and in silico search for small molecule binders Journal article
Frontiers in Immunology, 2018,Volume: 9,Issue: JUN
Authors:  Shaikh F.;  He J.;  Bhadra P.;  Chen X.;  Siu S.W.
Favorite |  | TC[WOS]:4 TC[Scopus]:7 | Submit date:2019/04/04
Drug discovery  MM-PBSA  Regulatory T cells  TNF  TNF receptor type II  Virtual screening  
TNF Receptor Type II as an Emerging Drug Target for the Treatment of Cancer, Autoimmune Diseases, and Graft-Versus-Host Disease: Current Perspectives and In Silico Search for Small Molecule Binders Journal article
FRONTIERS IN IMMUNOLOGY, 2018,Volume: 9
Authors:  Shaikh, Faraz;  He, Jiang;  Bhadra, Pratiti;  Chen, Xin;  Siu, Shirley W., I
Favorite |  | TC[WOS]:4 TC[Scopus]:7 | Submit date:2018/10/30
Tnf Receptor Type Ii  Tnf  Regulatory t Cells  Virtual Screening  Drug Discovery  Mm-pbsa  
Small Molecule Pin1 Inhibitor Blocking NF-B Signaling in Prostate Cancer Cells Journal article
CHEMISTRY-AN ASIAN JOURNAL, 2018,Volume: 13,Issue: 3,Page: 275-279
Authors:  Wu, Ke-Jia;  Zhong, Hai-Jing;  Yang, Guanjun;  Wu, Chun;  Huang, Jie-Min;  Li, Guodong;  Ma, Dik-Lung;  Leung, Chung-Hang
Favorite |  | TC[WOS]:22 TC[Scopus]:24 | Submit date:2018/10/30
Enzymes  Natural Products  Pin1  Protein-protein Interactions  Virtual Screening  
Identification of novel natural compound inhibitors for human complement component 5a receptor by homology modeling and virtual screening Journal article
Medicinal Chemistry Research, 2016,Volume: 25,Issue: 8,Page: 1564-1573
Authors:  Shaikh F.;  Siu S.W.I.
Favorite |  | TC[WOS]:6 TC[Scopus]:6 | Submit date:2019/04/04
C5aR  Homology modeling  MM-GBSA  Molecular docking  Natural compound inhibitor  Virtual screening  
Recent Advances in the Discovery and Development of Protein-Protein Interaction Modulators by Virtual Screening Book
2015
Authors:  Ma D.-L.;  Liu L.-J.;  Lin S.;  Wang M.;  Chan D.S.-H.;  Leung C.-H.
Favorite |  | TC[WOS]:0 TC[Scopus]:1 | Submit date:2018/11/06
Computer-aided drug discovery  Drug development  Molecular docking  Protein-protein interactions  Virtual screening