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A novel bioengineered fragment peptide of Vasostatin-1 exerts smooth muscle pharmacological activities and anti-angiogenic effects via blocking VEGFR signalling pathway Journal article
Computational and Structural Biotechnology Journal, 2021,Volume: 19,Page: 2664-2675
Authors:  Wei, Ran;  Wu, Qiushuang;  Ai, Nana;  Wang, Lei;  Zhou, Mei;  Shaw, Chris;  Chen, Tianbao;  Ye, Richard Dequan;  Ge, Wei;  Siu, Shirley W.I.;  Kwok, Hang Fai
Favorite |  | TC[WOS]:0 TC[Scopus]:0 | Submit date:2021/09/17
Anti-angiogenesis  Chromogranin a  Vasostatin-1  Vegfr2  
White learning methodology: A case study of cancer-related disease factors analysis in real-time PACS environment Journal article
Computer Methods and Programs in Biomedicine, 2020,Volume: 197
Authors:  Tengyue Li;  Simon Fong;  Shirley W.I. Siu;  Xin-she Yang;  Lian-Sheng Liu;  Sabah Mohammed
Favorite |  | TC[WOS]:0 TC[Scopus]:0 | Submit date:2021/03/09
Data Mining Methodology  Deep Learning  Bayesian Network  Radiological Data Analysis  
Novel venom-based peptides (P13 and its derivative - M6) to maintain self-renewal of human embryonic stem cells by activating FGF and TGFβ signaling pathways Journal article
Stem Cell Research and Therapy, 2020,Volume: 11,Issue: 1
Authors:  Ma,Rui;  Ren,Zhili;  Li,Bin;  Siu,Shirley W.I.;  Chen,Guokai;  Kwok,Hang Fai
Favorite |  | TC[WOS]:2 TC[Scopus]:2 | Submit date:2021/03/04
Embryonic stem cell  Peptide modification  Pluripotency  Self-renewal  Venom peptide  
Deep-AmPEP30: Improve Short Antimicrobial Peptides Prediction with Deep Learning Journal article
Molecular Therapy - Nucleic Acids, 2020,Volume: 20,Page: 882-894
Authors:  Yan,Jielu;  Bhadra,Pratiti;  Li,Ang;  Sethiya,Pooja;  Qin,Longguang;  Tai,Hio Kuan;  Wong,Koon Ho;  Siu,Shirley W.I.
Favorite |  | TC[WOS]:23 TC[Scopus]:27 | Submit date:2021/03/04
AmPEP  ampicillin  antimicrobial peptide  AxPEP  Candida glabrata  convolutional neural network  drug discovery  machine learning  reduced amino acid composition  
Evaluating Variants of Firefly Algorithm for Ligand Pose Prediction in Protein-ligand Docking Program Conference paper
PervasiveHealth: Pervasive Computing Technologies for Healthcare
Authors:  Ao, Meng Chi;  Siu, Shirley W.I.
Favorite |  | TC[WOS]:0 TC[Scopus]:0 | Submit date:2021/12/06
Firefly algorithm  FireflyVina  Logistic map  Lévy flight  Particle swarm optimization  Protein-ligand docking  PSOVina  
Study of Data Imbalanced Problem in Protein-peptide Binding Prediction Conference paper
PervasiveHealth: Pervasive Computing Technologies for Healthcare
Authors:  Gao, Lu;  Siu, Shirley W.I.
Favorite |  | TC[WOS]:0 TC[Scopus]:0 | Submit date:2021/12/06
Data imbalance  NearMiss  Protein-peptide binding residues  Under-sampling  
Machine learning approaches for quality assessment of protein structures Journal article
Biomolecules, 2020,Volume: 10,Issue: 4
Authors:  Chen, Jiarui;  Siu, Shirley W.I.
Favorite |  | TC[WOS]:0 TC[Scopus]:0 | Submit date:2021/12/06
CASP  Deep learning  DL  EMA  Estimating model quality  Machine learning  ML  Model quality assessment  MQA  Protein structure prediction  
In Vitro and MD Simulation Study to Explore Physicochemical Parameters for Antibacterial Peptide to Become Potent Anticancer Peptide Journal article
Molecular Therapy - Oncolytics, 2020,Volume: 16,Page: 7-19
Authors:  Ma,Rui;  Wong,Sin Wa;  Ge,Lilin;  Shaw,Chris;  Siu,Shirley W.I.;  Kwok,Hang Fai
Favorite |  | TC[WOS]:14 TC[Scopus]:14 | Submit date:2021/03/04
angiogenesis  anticancer peptides  antimicrobial peptides  apoptosis  drug discovery and development  molecular dynamics  targeted therapy  
Comparison of Cutoff Strategies for Geometrical Features in Machine Learning-Based Scoring Functions Conference paper
Advanced Data Mining and Applications, Hangzhou, China, 14-16 December,2013
Authors:  Shirley W.I. Siu;  Thomas K.F. Wong;  Simon Fong
Favorite |  | TC[WOS]:0 TC[Scopus]:0 | Submit date:2019/02/13
Scoring Function  Protein-ligand Binding Affinity  Geometrical Features  Machine Learning  Structure-based Drug Design