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Highly diversified core promoters in the human genome and their effects on gene expression and disease predisposition Journal article
BMC Genomics, 2020,Volume: 21,Issue: 1
Authors:  Gupta,Hemant;  Chandratre,Khyati;  Sinha,Siddharth;  Huang,Teng;  Wu,Xiaobing;  Cui,Jian;  Zhang,Michael Q.;  Wang,San Ming
Favorite |  | TC[WOS]:0 TC[Scopus]:0 | Submit date:2021/03/02
1000 genomes  Core promoter  eQTL  Exome  GWAS  Variation  
Classification of VUS and unclassified variants in BRCA1 BRCT repeats by molecular dynamics simulation Journal article
Computational and Structural Biotechnology Journal, 2020,Volume: 18,Page: 723-736
Authors:  Sinha,Siddharth;  Wang,San Ming
Favorite |  | TC[WOS]:13 TC[Scopus]:13 | Submit date:2021/03/02
BRCA1  BRCT  Molecular dynamics simulation  PCA  Unclassified variants  VUS  
Combining Ramachandran plot and molecular dynamics simulation for structural-based variant classification: Using TP53 variants as model Journal article
Computational and Structural Biotechnology Journal, 2020,Volume: 18,Page: 4033-4039
Authors:  Tam,Benjamin;  Sinha,Siddharth;  Wang,San Ming
Favorite |  | TC[WOS]:2 TC[Scopus]:3 | Submit date:2021/03/02
Molecular Dynamic Simulation  Pathogenic  Protein structure  Ramachandran plot  TP53  Variant of Uncertain Significance  
Coupled genome-wide DNA methylation and transcription analysis identified rich biomarkers and drug targets in triple-negative breast cancer Journal article
Cancers, 2019,Volume: 11,Issue: 11
Authors:  Guo,Maoni;  Sinha,Siddharth;  Wang,San Ming
Favorite |  | TC[WOS]:3 TC[Scopus]:3 | Submit date:2021/03/02
DNA methylation  Gene expression  Therapeutic targets  TNBC  
Germline variation in BRCA1/2 is highly ethnic-specific: Evidence from over 30,000 Chinese hereditary breast and ovarian cancer patients Journal article
International Journal of Cancer, 2019,Volume: 145,Issue: 4,Page: 962-973
Authors:  Bhaskaran,Shanmuga Priya;  Chandratre,Khyati;  Gupta,Hemant;  Zhang,Li;  Wang,Xiaoyu;  Cui,Jian;  Kim,Yeong C.;  Sinha,Siddharth;  Jiang,Luhan;  Lu,Boya;  Wu,Xiaobing;  Qin,Zixin;  Huang,Teng;  Wang,San Ming
Favorite |  | TC[WOS]:20 TC[Scopus]:21 | Submit date:2021/03/02
BRCA1  BRCA2  breast cancer  Chinese  ethnic-specific  mutation  population