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Simultaneous targeting of NPC1 and VDAC1 by itraconazole leads to synergistic inhibition of MTOR signaling and angiogenesis Journal article
ACS Chemical Biology, 2017,Volume: 12,Issue: 1,Page: 174
Authors:  Head S.A.;  Shi W.Q.;  Yang E.J.;  Nacev B.A.;  Hong S.Y.;  Pasunooti K.K.;  Li R.-J.;  Shim J.S.;  Liu J.O.
Favorite |  | TC[WOS]:35 TC[Scopus]:35 | Submit date:2018/10/30
Antidepressant indatraline induces autophagy and inhibits restenosis via suppression of mTOR/S6 kinase signaling pathway Journal article
Scientific Reports, 2016,Volume: 6
Authors:  Cho Y.S.;  Yen C.-N.;  Shim J.S.;  Kang D.H.;  Kang S.W.;  Liu J.O.;  Kwon H.J.
Favorite |  | TC[WOS]:15 TC[Scopus]:15 | Submit date:2019/01/15
Revisiting Non-Cancer Drugs for Cancer Therapy Journal article
Current Topics in Medicinal Chemistry, 2016,Volume: 16,Issue: 19,Page: 2144-2155
Authors:  Yang E.J.;  Wu C.;  Liu Y.;  Lv J.;  Shim J.S.
Favorite |  | TC[WOS]:8 TC[Scopus]:0 | Submit date:2019/01/15
Cancer  Disulfiram  Doxycycline  Drug Repositioning  Existing Drugs  Mebendazole  Pyrvinium Pamoate  Triclosan  
Divergence of antiangiogenic activity and hepatotoxicity of different stereoisomers of itraconazole Journal article
Clinical Cancer Research, 2016,Volume: 22,Issue: 11,Page: 2709-2720
Authors:  Shim J.S.;  Li R.-J.;  Bumpus N.N.;  Head S.A.;  Pasunooti K.K.;  Yang E.J.;  Lv J.;  Shi W.;  Liu J.O.
Favorite |  | TC[WOS]:9 TC[Scopus]:8 | Submit date:2019/01/15
The small molecule R-(-)-β-O-methylsynephrine binds to nucleoporin 153 kDa and inhibits angiogenesis Journal article
International Journal of Biological Sciences, 2015,Volume: 11,Issue: 9,Page: 1088-1099
Authors:  Kim N.H.;  Pham N.B.;  Quinn R.J.;  Shim J.S.;  Cho H.;  Cho S.M.;  Park S.W.;  Kim J.H.;  Seok S.H.;  Oh J.-W.;  Kwon H.J.
Favorite |  | TC[WOS]:8 TC[Scopus]:10 | Submit date:2019/01/15
Angiogenesis  Natural Product  Nup153  Small Molecule  Target Identification  
Antifungal drug itraconazole targets VDAC1 to modulate the AMPK/mTOR signaling axis in endothelial cells Journal article
Proceedings of the National Academy of Sciences of the United States of America, 2015,Volume: 112,Issue: 52,Page: E7276
Authors:  Head S.A.;  Shi W.;  Zhao L.;  Gorshkov K.;  Pasunooti K.;  Chen Y.;  Deng Z.;  Li R.-J.;  Shim J.S.;  Tan W.;  Hartung T.;  Zhang J.;  Zhao Y.;  Colombini M.;  Liu J.O.
Favorite |  | TC[WOS]:51 TC[Scopus]:51 | Submit date:2018/10/30
Angiogenesis  Itraconazole  Metabolism  Mitochondria  VDAC1  
First quantitative high-throughput screen in zebrafish identifies novel pathways for increasing pancreatic β-cell mass Journal article
eLife, 2015,Volume: 4,Issue: 2015-07-01
Authors:  Wang G.;  Rajpurohit S.K.;  Delaspre F.;  Walker S.L.;  White D.T.;  Ceasrine A.;  Kuruvilla R.;  Li R.-J.;  Shim J.S.;  Liu J.O.;  Parsons M.J.;  Mumm J.S.
Favorite |  | TC[WOS]:38 TC[Scopus]:57 | Submit date:2018/10/30
Inhibition of angiogenesis by selective estrogen receptor modulators through blockade of cholesterol trafficking rather than estrogen receptor antagonism Journal article
Cancer Letters, 2015,Volume: 362,Issue: 1,Page: 106-115
Authors:  Shim J.S.;  Li R.-J.;  Lv J.;  Head S.A.;  Yang E.J.;  Liu J.O.
Favorite |  | TC[WOS]:14 TC[Scopus]:16 | Submit date:2019/01/15
Angiogenesis  Cholesterol Trafficking  Selective Estrogen Receptor Modulator  Tamoxifen  
Identification of an old antibiotic clofoctol as a novel activator of unfolded protein response pathways and an inhibitor of prostate cancer Journal article
British Journal of Pharmacology, 2014,Volume: 171,Issue: 19,Page: 4478-4489
Authors:  Wang M.;  Shim J.S.;  Li R.-J.;  Dang Y.;  He Q.;  Das M.;  Liu J.O.
Favorite |  | TC[WOS]:17 TC[Scopus]:18 | Submit date:2019/01/15
Purpurin inhibits adipocyte-derived leucine aminopeptidase and angiogenesis in a zebrafish model Journal article
Biochemical and Biophysical Research Communications, 2014,Volume: 450,Issue: 1,Page: 561-567
Authors:  Park H.;  Shim J.S.;  Kim B.S.;  Jung H.J.;  Huh T.-L.;  Kwon H.J.
Favorite |  | TC[WOS]:14 TC[Scopus]:16 | Submit date:2019/01/15
Adipocyte-derived Leucine Aminopeptidase (A-lap)  Angiogenesis  Drug Screening  Purpurin