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Oxyphylla a promotes degradation of α-synuclein for neuroprotection via activation of immunoproteasome Journal article
Aging and Disease, 2020,Volume: 11,Issue: 3,Page: 559-574
Authors:  Zhou,Hefeng;  Li,Shengnan;  Li,Chuwen;  Yang,Xuanjun;  Li,Haitao;  Zhong,Hanbing;  Lu,Jia Hong;  Lee,Simon Ming Yuen
Favorite |  | TC[WOS]:1 TC[Scopus]:1 | Submit date:2021/03/01
Degradation  Neuroprotection  Parkinson's disease  Proteasome  α-synuclein  
Tetramethylpyrazine Analogue T-006 Promotes the Clearance of Alpha-synuclein by Enhancing Proteasome Activity in Parkinson’s Disease Models Journal article
Neurotherapeutics, 2019,Volume: 16,Issue: 4,Page: 1225-1236
Authors:  Zhou,Hefeng;  Shao,Min;  Guo,Baojian;  Li,Chuwen;  Lu,Yucong;  Yang,Xuanjun;  ShengnanLi,;  Li,Haitao;  Zhu,Qi;  Zhong,Hanbing;  Wang,Yuqiang;  Zhang,Zaijun;  Lu,Jiahong;  Lee,Simon Ming Yuen
Favorite |  | TC[WOS]:7 TC[Scopus]:7 | Submit date:2021/03/01
Degradation  LMP7  Parkinson’s disease  Proteasome activity  α-synuclein  
Natural alkaloid harmine promotes degradation of alpha-synuclein via PKA-mediated ubiquitin-proteasome system activation Journal article
Phytomedicine, 2019,Volume: 61
Authors:  Cai,Cui Zan;  Zhou,He Feng;  Yuan,Ning Ning;  Wu,Ming Yue;  Lee,Simon Ming Yuen;  Ren,Jiao Yan;  Su,Huan Xing;  Lu,Jin Jian;  Chen,Xiu Ping;  Li,Min;  Tan,Jie Qiong;  Lu,Jia Hong
Favorite |  | TC[WOS]:9 TC[Scopus]:8 | Submit date:2021/03/01
-synuclein  Harmine  Parkinson's Disease  Protein Kinase a  Ubiquitin-proteasome System  
Canthin-6-One Accelerates Alpha-Synuclein Degradation by Enhancing UPS Activity: Drug Target Identification by CRISPR-Cas9 Whole Genome-Wide Screening Technology Journal article
FRONTIERS IN PHARMACOLOGY, 2019
Authors:  Ning-Ning Yuan;  Cui-Zan Cai;  Ming-Yue Wu;  Qi Zhu;  HuanXing Su;  Min Li;  JiaoYan Ren;  Jie-Qiong Tan;  Jia-Hong Lu
Favorite |  | TC[WOS]:5 TC[Scopus]:7 | Submit date:2020/04/14
Canthin-6-one  Parkinson’s Disease  Alpha-synuclein  Ubiquitin-proteasome-system  Crispr/cas9  Rpn2/psmd1  Pka  
Osimertinib (AZD9291) decreases programmed death ligand-1 in EGFR-mutated non-small cell lung cancer cells Journal article
ACTA PHARMACOLOGICA SINICA, 2017,Volume: 38,Issue: 11,Page: 1512-1520
Authors:  Jiang, Xiao-Ming;  Xu, Yu-Lian;  Huang, Mu-Yang;  Zhang, Le-Le;  Su, Min-Xia;  Chen, Xiuping;  Lu, Jin-Jian
Favorite |  | TC[WOS]:25 TC[Scopus]:25 | Submit date:2018/10/30
Non-small Cell Lung Cancer  Egfr  Osimertinib  Pd-l1  Ubiquitin-proteasome System  Mg-132  Bortezomib  Gsk3 Beta  Licl  
The antitumor natural compound falcarindiol promotes cancer cell death by inducing endoplasmic reticulum stress Journal article
Cell Death and Disease, 2012,Volume: 3,Issue: 8
Authors:  Jin H.R.;  Zhao J.;  Zhang Z.;  Liao Y.;  Wang C.-Z.;  Huang W.-H.;  Li S.-P.;  He T.-C.;  Yuan C.-S.;  Du W.
Favorite |  | TC[WOS]:50 TC[Scopus]:53 | Submit date:2018/10/30
Apoptosis  ER stress  Falcarindiol  Proteasome  Unfolded protein response  
The 20S proteasome processes NF-kappaB1 p105 into p50 in a translation-independent manner Journal article
EMBO JOURNAL, 2006,Volume: 25,Issue: 9,Page: 1945-1956
Authors:  Anu K Moorthy;  Olga V Savinova;  Jessica Q Ho;  Vivien Ya-Fan Wang;  Don Vu;  Gourisankar Ghosh
Favorite |  | TC[WOS]:86 TC[Scopus]:89 | Submit date:2019/01/17
20s Proteasome  Nf-κb  P105  Processing  Ubiquitination