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Molecular landscape and subtype-specific therapeutic response of nasopharyngeal carcinoma revealed by integrative pharmacogenomics Journal article
Nature Communications, 2021,Volume: 12,Issue: 1
Authors:  Ding, Ren Bo;  Chen, Ping;  Rajendran, Barani Kumar;  Lyu, Xueying;  Wang, Haitao;  Bao, Jiaolin;  Zeng, Jianming;  Hao, Wenhui;  Sun, Heng;  Wong, Ada Hang Heng;  Valecha, Monica Vishnu;  Yang, Eun Ju;  Su, Sek Man;  Choi, Tak Kan;  Liu, Shuiming;  Chan, Kin Iong;  Yang, Ling Lin;  Wu, Jingbo;  Miao, Kai;  Chen, Qiang;  Shim, Joong Sup;  Xu, Xiaoling;  Deng, Chu Xia
Favorite |  | TC[WOS]:1 TC[Scopus]:1 | Submit date:2021/11/30
Activation of FGFR2 Signaling Suppresses BRCA1 and Drives Triple-Negative Mammary Tumorigenesis That is Sensitive to Immunotherapy Journal article
Advanced Science, 2021,Volume: 8,Issue: 21
Authors:  Lei, Josh Haipeng;  Lee, Mi Hye;  Miao, Kai;  Huang, Zebin;  Yao, Zhicheng;  Zhang, Aiping;  Xu, Jun;  Zhao, Ming;  Huang, Zenan;  Zhang, Xin;  Chen, Si;  Jiaying, N. G.;  Feng, Yuzhao;  Xing, Fuqiang;  Chen, Ping;  Sun, Heng;  Chen, Qiang;  Xiang, Tingxiu;  Chen, Lin;  Xu, Xiaoling;  Deng, Chu Xia
Favorite |  | TC[WOS]:0 TC[Scopus]:0 | Submit date:2021/11/30
BRCA1  breast cancer  FGFR2 inhibitor  FGFR2-S252W  tumor slice culture  
Patient-Derived Organoids Can Guide Personalized-Therapies for Patients with Advanced Breast Cancer Journal article
Advanced Science, 2021,Volume: 8,Issue: 22
Authors:  Chen, Ping;  Zhang, Xu;  Ding, Renbo;  Yang, Linglin;  Lyu, Xueying;  Zeng, Jianming;  Lei, Josh Haipeng;  Wang, Lijian;  Bi, Jiong;  Shao, Nan;  Shu, Ditian;  Wu, Bin;  Wu, Jingbo;  Yang, Zhihui;  Wang, Haiyan;  Wang, Biqiong;  Xiong, Kang;  Lu, Yun;  Fu, Shaozhi;  Choi, Tak Kan;  Lon, Ng Wai;  Zhang, Aiping;  Tang, Dongyang;  Quan, Yingyao;  Meng, Ya;  Miao, Kai;  Sun, Heng;  Zhao, Ming;  Bao, Jiaolin;  Zhang, Lei;  Xu, Xiaoling;  Shi, Yanxia;  Lin, Ying;  Deng, Chuxia
Favorite |  | TC[WOS]:0 TC[Scopus]:0 | Submit date:2021/11/30
advanced breast cancer  drug screening  patient-derived organoids  personalized therapy  
Deciphering the autophagy regulatory network via single-cell transcriptome analysis reveals a requirement for autophagy homeostasis in spermatogenesis Journal article
Theranostics, 2021,Volume: 11,Issue: 10,Page: 5010-5027
Authors:  Wang, Mei;  Xu, Yanwen;  Zhang, Yuncong;  Chen, Yuhan;  Chang, Gang;  An, Geng;  Yang, Xinyan;  Zheng, Caihong;  Zhao, Jiexiang;  Liu, Zhaoting;  Wang, Dazhuang;  Miao, Kai;  Rao, Shuan;  Dai, Meng;  Wang, Dong;  Zhao, Xiao Yang
Favorite |  | TC[WOS]:1 TC[Scopus]:0 | Submit date:2021/11/30
Autophagy  Male infertility  Meiosis  Single-cell RNA sequencing  Spermatogenesis  Spermatogonial stem cells  
Accelerating precision anti-cancer therapy by time-lapse and label-free 3D tumor slice culture platform Journal article
Theranostics, 2021,Volume: 11,Issue: 19,Page: 9415-9430
Authors:  Xing, Fuqiang;  Liu, Yu Cheng;  Huang, Shigao;  Lyu, Xueying;  Su, Sek Man;  Chan, Un In;  Wu, Pei Chun;  Yan, Yinghan;  Ai, Nana;  Li, Jianjie;  Zhao, Ming;  Rajendran, Barani Kumar;  Liu, Jianlin;  Shao, Fangyuan;  Sun, Heng;  Choi, Tak Kan;  Zhu, Wenli;  Luo, Guanghui;  Liu, Shuiming;  Xu, De Li;  Chan, Kin Long;  Zhao, Qi;  Miao, Kai;  Luo, Kathy Qian;  Ge, Wei;  Xu, Xiaoling;  Wang, Guanyu;  Liu, Tzu Ming;  Deng, Chu Xia
Favorite |  | TC[WOS]:0 TC[Scopus]:0 | Submit date:2021/11/30
3D tumor slice culture  Apoptosis  FRET technique  Label-free  Personalized medicine  
Dissecting the heterogeneity and tumorigenesis of BRCA1 deficient mammary tumors via single cell RNA sequencing Journal article
Theranostics, 2021,Volume: 11,Issue: 20,Page: 9967-9987
Authors:  Sun, Heng;  Zeng, Jianming;  Miao, Zhengqiang;  Lei, Kuan Cheok;  Huang, Chen;  Hu, Lingling;  Su, Sek Man;  Chan, Un In;  Miao, Kai;  Zhang, Xu;  Zhang, Aiping;  Guo, Sen;  Chen, Si;  Meng, Ya;  Deng, Min;  Hao, Wenhui;  Lei, Haipeng;  Lin, Ying;  Yang, Zhonglin;  Tang, Dongjiang;  Wong, Koon Ho;  Zhang, Xiaohua Douglas;  Xu, Xiaoling;  Deng, Chu Xia
Favorite |  | TC[WOS]:0 TC[Scopus]:0 | Submit date:2021/11/30
Brca1/BRCA1  Mammary tumor  Mrc2  Single cell RNA-seq  Tumor heterogeneity  
Characterization of BRCA1-deficient premalignant tissues and cancers identifies Plekha5 as a tumor metastasis suppressor Journal article
Nature Communications, 2020,Volume: 11,Issue: 1
Authors:  Liu,Jianlin;  Adhav,Ragini;  Miao,Kai;  Su,Sek Man;  Mo,Lihua;  Chan,Un In;  Zhang,Xin;  Xu,Jun;  Li,Jianjie;  Shu,Xiaodong;  Zeng,Jianming;  Zhang,Xu;  Lyu,Xueying;  Pardeshi,Lakhansing;  Tan,Kaeling;  Sun,Heng;  Wong,Koon Ho;  Deng,Chuxia;  Xu,Xiaoling
Favorite |  | TC[WOS]:8 TC[Scopus]:8 | Submit date:2021/03/02
Enhanced Protein Damage Clearance Induces Broad Drug Resistance in Multitype of Cancers Revealed by an Evolution Drug-Resistant Model and Genome-Wide siRNA Screening Journal article
Advanced Science, 2020,Volume: 7,Issue: 23
Authors:  Shao,Fangyuan;  Lyu,Xueying;  Miao,Kai;  Xie,Lisi;  Wang,Haitao;  Xiao,Hao;  Li,Jie;  Chen,Qiang;  Ding,Renbo;  Chen,Ping;  Xing,Fuqiang;  Zhang,Xu;  Luo,Guang Hui;  Zhu,Wenli;  Cheng,Gregory;  Lon,Ng Wai;  Martin,Scott E.;  Wang,Guanyu;  Chen,Guokai;  Dai,Yunlu;  Deng,Chu Xia
Favorite |  | TC[WOS]:3 TC[Scopus]:3 | Submit date:2021/03/02
Broad Drug Resistance  Caspase 3 Activation  Patient-derived Organoid  Proteolysis  Rnai Screening  
NOTCH1 activation compensates BRCA1 deficiency and promotes triple-negative breast cancer formation Journal article
Nature Communications, 2020,Volume: 11,Issue: 1
Authors:  Miao,Kai;  Lei,Josh Haipeng;  Valecha,Monica Vishnu;  Zhang,Aiping;  Xu,Jun;  Wang,Lijian;  Lyu,Xueying;  Chen,Si;  Miao,Zhengqiang;  Zhang,Xin;  Su,Sek Man;  Shao,Fangyuan;  Rajendran,Barani Kumar;  Bao,Jiaolin;  Zeng,Jianming;  Sun,Heng;  Chen,Ping;  Tan,Kaeling;  Chen,Qiang;  Wong,Koon Ho;  Xu,Xiaoling;  Deng,Chu Xia
Favorite |  | TC[WOS]:11 TC[Scopus]:11 | Submit date:2020/09/16
BRCA1 Deficiency Impairs Mitophagy and Promotes Inflammasome Activation and Mammary Tumor Metastasis Journal article
Advanced Science, 2020,Volume: 7,Issue: 6
Authors:  Chen,Qiang;  Lei,Josh Haipeng;  Bao,Jiaolin;  Wang,Haitao;  Hao,Wenhui;  Li,Licen;  Peng,Cheng;  Masuda,Takaaki;  Miao,Kai;  Xu,Jun;  Xu,Xiaoling;  Deng,Chu Xia
Favorite |  | TC[WOS]:18 TC[Scopus]:19 | Submit date:2020/09/16
Atm-ampk-drp1  Brca1  Inflammasomes  Mitochondrial Dynamics  Mitophagy