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Using Acetone/Water Binary Solvent to Enhance the Stability and Bioavailability of Spray Dried Enzalutamide/HPMC-AS Solid Dispersions Journal article
Journal of Pharmaceutical Sciences, 2021,Volume: 110,Issue: 3,Page: 1160-1171
Authors:  Zhang,Xiaoting;  Rao,Qiuhong;  Qiu,Zhenwen;  Lin,Yisheng;  Zhang,Lei;  Hu,Qingzhong;  Chen,Tingting;  Ma,Zhimin;  Gao,Hanlu;  Luo,Dandong;  Zhao,Jiaqi;  Ouyang,Defang;  Zhang,Zhenyu Jason;  Li,Qingguo
Favorite |  | TC[WOS]:0 TC[Scopus]:1 | Submit date:2021/03/02
Amorphous solid dispersion  Drug-excipient interaction  Particle size  Poorly water-soluble drug  Spray drying  
An integrated computational methodology with data-driven machine learning, molecular modeling and PBPK modeling to accelerate solid dispersion formulation design Journal article
European Journal of Pharmaceutics and Biopharmaceutics, 2021,Volume: 158,Page: 336-346
Authors:  Gao,Hanlu;  Wang,Wei;  Dong,Jie;  Ye,Zhuyifan;  Ouyang,Defang
Favorite |  | TC[WOS]:0 TC[Scopus]:0 | Submit date:2021/03/02
Dissolution profile  Machine learning  molecular dynamics (MD) simulations  Pharmacokinetic modeling  Solid dispersion  
Predicting drug/phospholipid complexation by the lightGBM method Journal article
Chemical Physics Letters, 2020,Volume: 747
Authors:  Gao,Haoshi;  Ye,Zhuyifan;  Dong,Jie;  Gao,Hanlu;  Yu,Hua;  Li,Haifeng;  Ouyang,Defang
Favorite |  | TC[WOS]:2 TC[Scopus]:2 | Submit date:2021/03/02
The novel platinum(IV) prodrug with self-assembly property and structure-transformable character against triple-negative breast cancer Journal article
Biomaterials, 2020,Volume: 232
Authors:  Yang,Conglian;  Tu,Kun;  Gao,Hanlu;  Zhang,Liao;  Sun,Yu;  Yang,Ting;  Kong,Li;  Ouyang,Defang;  Zhang,Zhiping
Favorite |  | TC[WOS]:5 TC[Scopus]:5 | Submit date:2021/03/02
Adjudin  Drug resistance  Platinum(IV) prodrug  Self-assembly  Structure transform  Triple-negative breast cancer