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Simultaneous blocking of the pan-RAF and S100B pathways as a synergistic therapeutic strategy against malignant melanoma Journal article
Journal of Cellular and Molecular Medicine, 2021,Volume: 25,Issue: 4,Page: 1972-1981
Authors:  Wu,Ke Jia;  Ho,Shih Hsin;  Wu,Chun;  Wang,Hui Min D.;  Ma,Dik Lung;  Leung,Chung Hang
Favorite |  | TC[WOS]:0 TC[Scopus]:0 | Submit date:2021/03/01
drug discovery  malignant melanoma  pan-RAF  S100B-p53 interaction  synergistic  
Natural Products in Cancer Therapy: Past, Present and Future Journal article
Natural Products and Bioprospecting, 2021
Authors:  Huang,Min;  Lu,Jin Jian;  Ding,Jian
Favorite |  | TC[WOS]:1 TC[Scopus]:0 | Submit date:2021/03/02
Antibody–drug conjugates  Cancer therapy  Combination therapy  Drug discovery  Natural products  
Natural Products in Cancer Therapy: Past, Present and Future Journal article
Natural Products and Bioprospecting, 2021
Authors:  Huang,Min;  Lu,Jin Jian;  Ding,Jian
Favorite |  | TC[WOS]:1 TC[Scopus]:0 | Submit date:2021/03/02
Antibody–drug conjugates  Cancer therapy  Combination therapy  Drug discovery  Natural products  
Deep-AmPEP30: Improve Short Antimicrobial Peptides Prediction with Deep Learning Journal article
Molecular Therapy - Nucleic Acids, 2020,Volume: 20,Page: 882-894
Authors:  Yan,Jielu;  Bhadra,Pratiti;  Li,Ang;  Sethiya,Pooja;  Qin,Longguang;  Tai,Hio Kuan;  Wong,Koon Ho;  Siu,Shirley W.I.
Favorite |  | TC[WOS]:8 TC[Scopus]:8 | Submit date:2021/03/04
AmPEP  ampicillin  antimicrobial peptide  AxPEP  Candida glabrata  convolutional neural network  drug discovery  machine learning  reduced amino acid composition  
In Vitro and MD Simulation Study to Explore Physicochemical Parameters for Antibacterial Peptide to Become Potent Anticancer Peptide Journal article
Molecular Therapy - Oncolytics, 2020,Volume: 16,Page: 7-19
Authors:  Ma,Rui;  Wong,Sin Wa;  Ge,Lilin;  Shaw,Chris;  Siu,Shirley W.I.;  Kwok,Hang Fai
Favorite |  | TC[WOS]:9 TC[Scopus]:10 | Submit date:2021/03/04
angiogenesis  anticancer peptides  antimicrobial peptides  apoptosis  drug discovery and development  molecular dynamics  targeted therapy  
Mimicking strategy for protein-protein interaction inhibitor discovery by virtual screening Journal article
Molecules, 2019,Volume: 24,Issue: 24
Authors:  Wu,Ke Jia;  Lei,Pui Man;  Liu,Hao;  Wu,Chun;  Leung,Chung Hang;  Ma,Dik Lung
Favorite |  | TC[WOS]:3 TC[Scopus]:4 | Submit date:2021/03/01
Drug discovery  Mimetics  Protein-protein interactions  Virtual screening  
High content screening for drug discovery from traditional Chinese medicine Journal article
Chinese Medicine (United Kingdom), 2019,Volume: 14,Issue: 1
Authors:  Wang,Jing;  Wu,Ming Yue;  Tan,Jie Qiong;  Li,Min;  Lu,Jia Hong
Favorite |  | TC[WOS]:6 TC[Scopus]:6 | Submit date:2021/03/02
Advanced models  Drug discovery  High-content screening  Progressive instruments  Traditional Chinese medicine  
LFB: A Novel Antimicrobial Brevinin-Like Peptide from the Skin Secretion of the Fujian Large Headed Frog, Limnonectes fujianensi Journal article
BIOMOLECULES, 2019,Volume: 9,Issue: 6
Authors:  Bin Li;  Peng Lyu;  Shuping Xie;  Haixin Qin;  Wenyuan Pu;  Houxi Xu;  Tianbao Chen;  Chris Shaw;  Lilin Ge;  Hang Fai Kwok
Favorite |  | TC[WOS]:3 TC[Scopus]:5 | Submit date:2020/05/20
Amphibian  Brevinin-like Peptide  Antimicrobial Peptides  Drug Discovery  
Rapid identification of antimicrometastases drugs using integrated model systems with two dimensional monolayer, three dimensional spheroids, and zebrafish xenotransplantation tumors Journal article
BIOTECHNOLOGY AND BIOENGINEERING, 2018,Volume: 115,Issue: 11,Page: 2828-2843
Authors:  Fu, Afu;  Peh, Yu Ming;  Ngan, Weida;  Wei, Na;  Luo, Kathy Qian
Favorite |  | TC[WOS]:7 TC[Scopus]:7 | Submit date:2019/01/17
antimetastasis drug discovery  fluorescence resonance energy transfer  PI3K  AKT pathway  three dimensional tumor spheroids  zebrafish xenograft tumor model  
Selective Inhibition of Lysine-Specific Demethylase 5A (KDM5A) Using a Rhodium(III) Complex for Triple-Negative Breast Cancer Therapy Journal article
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2018,Volume: 57,Issue: 40,Page: 13091-13095
Authors:  Yang, Guan-Jun;  Wang, Wanhe;  Mok, Simon Wing Fai;  Wu, Chun;  Law, Betty Yuen Kwan;  Miao, Xiang-Min;  Wu, Ke-Jia;  Zhong, Hai-Jing;  Wong, Chun-Yuen;  Wong, Vincent Kam Wai;  Ma, Dik-Lung;  Leung, Chung-Hang
Favorite |  | TC[WOS]:47 TC[Scopus]:50 | Submit date:2018/10/30
Drug Discovery  Epigenetics  Medicinal Chemistry  Triple-negative Breast Cancer