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An Isoquinolinium Dual Inhibitor of Cholinesterases and Amyloid β Aggregation Mitigates Neuropathological Changes in a Triple-Transgenic Mouse Model of Alzheimer's Disease Journal article
ACS Chemical Neuroscience, 2020,Volume: 11,Issue: 20,Page: 3346-3357
Authors:  Ju,Yaojun;  Chakravarty,Harapriya;  Tam,Kin Yip
Favorite |  | TC[WOS]:0 TC[Scopus]:0 | Submit date:2021/03/04
Alzheimer's disease  amyloid beta  cholinesterase  dual inhibition  
Dual targeting of cholinesterase and amyloid beta with pyridinium/isoquinolium derivatives Journal article
Drug Development Research, 2020,Volume: 81,Issue: 2,Page: 242-255
Authors:  Chakravarty,Harapriya;  Ju,Yaojun;  Chen,Wen Hua;  Tam,Kin Y.
Favorite |  | TC[WOS]:3 TC[Scopus]:4 | Submit date:2021/03/04
acetylcholinesterase  Alzheimer's disease  amyloid beta  butyrylcholinesterase  dual target inhibitor  isoquinolinium  pyridinium  
Anticancer effects of some novel dichloroacetophenones through the inhibition of pyruvate dehydrogenase kinase 1 Journal article
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, 2018,Volume: 123,Page: 43-55
Authors:  Zhang, Shao-Lin;  Yang, Zheng;  Hu, Xiaohui;  Chakravarty, Harapriya;  Tam, Kin Yip
Favorite |  | TC[WOS]:6 TC[Scopus]:7 | Submit date:2018/10/30
Dichloroacetophenone  Pyruvate Dehydrogenase Kinase  Pyruvate Dehydrogenase Complex  Anticancer Activity  Metabolic Reprogramming  
Astemizole inhibits mTOR signaling and angiogenesis by blocking cholesterol trafficking Journal article
International Journal of Biological Sciences, 2018,Volume: 14,Issue: 10,Page: 1175-1185
Authors:  Lyu,Junfang;  Yang,Eun Ju;  Head,Sarah A.;  Ai,Nana;  Zhang,Baoyuan;  Wu,Changjie;  Li,Ruo Jing;  Liu,Yifan;  Chakravarty,Harapriya;  Zhang,Shaolin;  Tam,Kin Yip;  Dang,Yongjun;  Kwon,Ho Jeong;  Ge,Wei;  Liu,Jun O.;  Shim,Joong Sup
Favorite |  | TC[WOS]:3 TC[Scopus]:3 | Submit date:2021/03/02
Angiogenesis  Astemizole  Cholesterol trafficking  mTOR  NPC1  
Identification of a Wells-Dawson polyoxometalate-based AP-2 gamma inhibitor with pro-apoptotic activity Journal article
BIOCHEMICAL JOURNAL, 2018,Volume: 475,Issue: 11,Page: 1965-1977
Authors:  Hu, Jiamiao;  Tan, Si Kee;  Lim, Michelle Gek Liang;  Chang, Shie Hong;  Cui, Guimei;  Liu, Shanshan;  Narasimhan, Kamesh;  New, Siu Yee;  Wang, Xuecong;  Chen, Congling;  Chakravarty, Harapriya;  Kolatkar, Prasanna R.;  Tam, Kin Yip;  Lu, Qian;  Su, Xiaodi;  Jauch, Ralf;  Cheung, Edwin
Favorite |  | TC[WOS]:3 TC[Scopus]:3 | Submit date:2018/10/30
Ap-2γ  Breast Cancer  Fluorescent Anisotropic  Polyoxometalate  
Astemizole Inhibits mTOR Signaling and Angiogenesis by Blocking Cholesterol Trafficking Journal article
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES, 2018,Volume: 14,Issue: 10,Page: 1175-1185
Authors:  Lyu, Junfang;  Yang, Eun Ju;  Head, Sarah A.;  Ai, Nana;  Zhang, Baoyuan;  Wu, Changjie;  Li, Ruo-Jing;  Liu, Yifan;  Chakravarty, Harapriya;  Zhang, Shaolin;  Tam, Kin Yip;  Dang, Yongjun;  Kwon, Ho Jeong;  Gel, Wei;  Liu, Jun O.;  Shim, Joong Sup
Favorite |  | TC[WOS]:3 TC[Scopus]:3 | Submit date:2018/10/30
Cholesterol Trafficking  Angiogenesis  Astemizole  Npc1  Mtor