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Synthesis, biological evaluation and structure-activity relationship of novel dichloroacetophenones targeting pyruvate dehydrogenase kinases with potent anticancer activity Journal article
European Journal of Medicinal Chemistry, 2021,Volume: 214
Authors:  Xu,Biao;  Wang,Zhi Peng;  Liu,Qingwang;  Yang,Xiaohong;  Li,Xuemin;  Huang,Ding;  Qiu,Yanfei;  Tam,Kin Yip;  Zhang,Shao Lin;  He,Yun
Favorite |  | TC[WOS]:0 TC[Scopus]:0 | Submit date:2021/03/04
Cancer metabolism  Proliferation  Pyruvate dehydrogenase kinase  Structure-activity relationship  
Development of dual inhibitors targeting pyruvate dehydrogenase kinases and human lactate dehydrogenase A: High-throughput virtual screening, synthesis and biological validation Journal article
European Journal of Medicinal Chemistry, 2020,Volume: 203
Authors:  Xiang,Sichuan;  Huang,Ding;  He,Qiaolin;  Li,Jie;  Tam,Kin Yip;  Zhang,Shao Lin;  He,Yun
Favorite |  | TC[WOS]:2 TC[Scopus]:2 | Submit date:2021/03/04
Cancer metabolism  Cancer proliferation  Dual inhibitor  Lactate dehydrogenase A  Pyruvate dehydrogenase kinase  
Role of FOXO Transcription Factors in Cancer Metabolism and Angiogenesis Journal article
Cells, 2020,Volume: 9,Issue: 7
Authors:  Farhan,Mohd;  Silva,Marta;  Xingan,Xing;  Huang,Yu;  Zheng,Wenhua
Favorite |  | TC[WOS]:4 TC[Scopus]:4 | Submit date:2021/03/04
angiogenesis  cancer  cancer metabolism  FOXOs  
The epigenetically downregulated factor CYGB suppresses breast cancer through inhibition of glucose metabolism Journal article
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH, 2018,Volume: 37
Authors:  Feng, Yixiao;  Wu, Mingjun;  Li, Shuman;  He, Xiaoqian;  Tang, Jun;  Peng, Weiyan;  Zeng, Beilei;  Deng, Chuxia;  Ren, Guosheng;  Xiang, Tingxiu
Favorite |  | TC[WOS]:4 TC[Scopus]:6 | Submit date:2019/01/17
CYGB  GLUT1  HXK2  p53  Breast cancer  Metabolism  Glycolysis  
Liquid Chromatography-Tandem Mass Spectrometry Method Revealed that Lung Cancer Cells Exhibited Distinct Metabolite Profiles upon the Treatment with Different Pyruvate Dehydrogenase Kinase Inhibitors Journal article
JOURNAL OF PROTEOME RESEARCH, 2018,Volume: 17,Issue: 9,Page: 3012-3021
Authors:  Zhang, Wen;  Hu, Xiaohui;  Zhou, Wei;  Tam, Kin Yip
Favorite |  | TC[WOS]:7 TC[Scopus]:6 | Submit date:2018/10/30
Aerobic Glycolysis  Azd7545  Dichloroacetate  Lc-ms/ms  Pyruvate Dehydrogenase Kinases  Cancer Metabolism  
GLUT12 promotes prostate cancer cell growth and is regulated by androgens and CaMKK2 signaling Journal article
ENDOCRINE-RELATED CANCER, 2018,Volume: 25,Issue: 4,Page: 453-469
Authors:  White, Mark A.;  Tsouko, Efrosini;  Lin, Chenchu;  Rajapakshe, Kimal;  Spencer, Jeffrey M.;  Wilkenfeld, Sandi R.;  Vakili, Sheiva S.;  Pulliam, Thomas L.;  Awad, Dominik;  Nikolos, Fotis;  Katreddy, Rajasekhara Reddy;  Kaipparettu, Benny Abraham;  Sreekumar, Arun;  Zhang, Xiaoliu;  Cheung, Edwin;  Coarfa, Cristian;  Frigo, Daniel E.
Favorite |  | TC[WOS]:18 TC[Scopus]:19 | Submit date:2018/10/30
Glut12  Slc2a12  Glucose Metabolism  Androgen Receptor (Ar)  Calcium/calmodulin-dependent Protein Kinase Kinase 2 (Camkk2)  5 '-amp-activated Protein Kinase (Ampk)  Prostate Cancer  
Phenyl butyrate inhibits pyruvate dehydrogenase kinase 1 and contributes to its anti-cancer effect Journal article
European Journal of Pharmaceutical Sciences, 2017,Volume: 110,Page: 93-100
Authors:  Zhang,Wen;  Zhang,Shao Lin;  Hu,Xiaohui;  Tam,Kin Yip
Favorite |  | TC[WOS]:8 TC[Scopus]:10 | Submit date:2021/03/04
Cancer  Phenyl butyrate  Pyruvate dehydrogenase  Pyruvate dehydrogenase kinase 1  Tumor metabolism  
Phenyl butyrate inhibits pyruvate dehydrogenase kinase 1 and contributes to its anti-cancer effect Conference paper
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, Zhuhai, PEOPLES R CHINA, 2016-8-23-26
Authors:  Zhang, Wen;  Zhang, Shao-Lin;  Hu, Xiaohui;  Tam, Kin Yip
Favorite |  | TC[WOS]:8 TC[Scopus]:10 | Submit date:2018/10/30
Phenyl Butyrate  Cancer  Pyruvate Dehydrogenase  Pyruvate Dehydrogenase Kinase 1  Tumor Metabolism  
BRCA1 and estrogen/estrogen receptor in breast cancer: Where they interact? Journal article
International Journal of Biological Sciences, 2014,Volume: 10,Issue: 5,Page: 563-573
Authors:  Wang,Li;  Di,Li Jun
Favorite |  | TC[WOS]:36 TC[Scopus]:43 | Submit date:2021/03/04
BRCA1  Breast cancer  Cell metabolism  Estrogen  Estrogen receptor  Mammary gland development  Oxidative stress  ROS  
BRCA1 And Estrogen/Estrogen Receptor In Breast Cancer: Where They Interact? Journal article
International Journal of Biological Sciences, 2014,Volume: 10,Issue: 5,Page: 566-575
Authors:  Li Wang;  Li-Jun Di
Favorite |  | TC[WOS]:36 TC[Scopus]:43 | Submit date:2019/01/04
Estrogen  Oxidative Stress  Brca1  Mammary Gland Development  Ros  Breast Cancer  Cell Metabolism  Estrogen Receptor