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Garciesculenxanthone B induces PINK1-Parkin-mediated mitophagy and prevents ischemia-reperfusion brain injury in mice Journal article
Acta Pharmacologica Sinica, 2021,Volume: 42,Issue: 2,Page: 199-208
Authors:  Wu,Man;  Lu,Guang;  Lao,Yuan zhi;  Zhang,Hong;  Zheng,Dan;  Zheng,Zhao qing;  Yi,Juan;  Xiang,Qian;  Wang,Li ming;  Tan,Hong sheng;  Zhou,Hua;  Shen,Han ming;  Xu,Hong xi
Favorite |  | TC[WOS]:2 TC[Scopus]:3 | Submit date:2021/03/02
garciesculenxanthone B  ischemia-reperfusion injury  mitophagy  Parkin  PINK1  
TGFβ2-mediated epithelial–mesenchymal transition and NF-κB pathway activation contribute to osimertinib resistance Journal article
Acta Pharmacologica Sinica, 2020,Volume: 42,Issue: 3,Page: 451-459
Authors:  Jiang,Xiao ming;  Xu,Yu lian;  Yuan,Luo wei;  Zhang,Le le;  Huang,Mu yang;  Ye,Zi han;  Su,Min xia;  Chen,Xiu ping;  Zhu,Hong;  Ye,Richard D.;  Lu,Jin jian
Favorite |  | TC[WOS]:4 TC[Scopus]:4 | Submit date:2021/03/01
Egfr Mutant Non-small Cell Lung Cancer  Epithelial-mesenchymal Transition  Nf-κb  Osimertinib Resistance  Tgfβ2  
Identification of nagilactone E as a protein synthesis inhibitor with anticancer activity Journal article
Acta Pharmacologica Sinica, 2020,Volume: 41,Issue: 5,Page: 698-705
Authors:  Zhang,Le le;  Guo,Jing;  Jiang,Xiao ming;  Chen,Xiu ping;  Wang,Yi tao;  Li,Ao;  Lin,Li gen;  Li,Hua;  Lu,Jin jian
Favorite |  | TC[WOS]:11 TC[Scopus]:11 | Submit date:2021/03/01
Click-it  Cmap  Diterpenoids  Human Lung Cancer A549 Cell Line Xenograft  Molecular Docking  Nagilactone e  Protein Synthesis Inhibitor  Riok2  Rna-seq  
Post-translational modification of KRAS: potential targets for cancer therapy Journal article
Acta Pharmacologica Sinica, 2020
Authors:  Wang,Wei hua;  Yuan,Tao;  Qian,Mei jia;  Yan,Fang jie;  Yang,Liu;  He,Qiao jun;  Yang,Bo;  Lu,Jin jian;  Zhu,Hong
Favorite |  | TC[WOS]:4 TC[Scopus]:4 | Submit date:2021/03/02
Acetylation  Cancer Therapy  Kras  Nitrosylation  Oncogene  Palmitoylation  Phosphorylation  Post-translational Modification  Postprenylation  Prenylation  Sumoylation  Ubiquitination  
Nitazoxanide, an anti-parasitic drug, efficiently ameliorates learning and memory impairments in AD model mice Journal article
ACTA PHARMACOLOGICA SINICA, 2019,Volume: 40,Issue: 10,Page: 1279-1291
Authors:  Lei Fan;  Xiao-xia Qiu;  Zhi-yuan Zhu;  Jian-lu Lv;  Jian Lu;  Fei Mao;  Jin Zhu;  Jia-ying Wang;  Xiao-wei Guan;  Jing Chen;  Jin Ren;  Ji-ming Ye;  Yong-hua Zhao;  Jian Li;  Xu Shen
Favorite |  | TC[WOS]:12 TC[Scopus]:14 | Submit date:2020/04/14
App/ps1 Transgenic Mice  Alzheimer’s Disease  Autophagy  Inflammation  Nitazoxanide  
Small molecule IVQ, as a prodrug of gluconeogenesis inhibitor QVO, efficiently ameliorates glucose homeostasis in type 2 diabetic mice Journal article
ACTA PHARMACOLOGICA SINICA, 2019,Volume: 40,Issue: 9,Page: 1193-1204
Authors:  Ting-ting Zhou;  Tong Zhao;  Fei Ma;  Yi-nan Zhang;  Jing Jiang;  Yuan Ruan;  Qiu-ying Yan;  Gai-hong Wang;  Jin Ren;  Xiao-wei Guan;  Jun Guo;  Yong-hua Zhao;  Ji-ming Ye;  Li-hong Hu;  Jing Chen;  Xu Shen
Favorite |  | TC[WOS]:3 TC[Scopus]:3 | Submit date:2020/04/14
Type 2 Diabetes Mellitus  Hepatic Gluconeogenesis  Ampk Signaling Pathway  (e)-3-(2-(Quinoline-4-yl)Vinyl)-1h-indol-6-ol (Qvo)  4-[2-(1h-indol-3-yl)Vinyl]Quinoline (Ivq)  Prodrug  
Main active constituent identification in Guanxinjing capsule, a traditional Chinese medicine, for the treatment of coronary heart disease complicated with depression Journal article
ACTA PHARMACOLOGICA SINICA, 2018,Volume: 39,Issue: 6,Page: 975-987
Authors:  Zhang, Yan-qiong;  Guo, Qiu-yan;  Li, Qiu-yue;  Ren, Wei-qiong;  Tang, Shi-huan;  Wang, Song-song;  Liang, Ri-xin;  Li, De-feng;  Zhang, Yi;  Xu, Hai-yu;  Yang, Hong-jun
Favorite |  | TC[WOS]:18 TC[Scopus]:26 | Submit date:2018/10/30
traditional Chinese medicine  Guanxinjing capsule  coronary heart disease  depression  integrative pharmacology  in silico ADME prediction  target prediction  network analysis  
Osimertinib (AZD9291) decreases programmed death ligand-1 in EGFR-mutated non-small cell lung cancer cells Journal article
ACTA PHARMACOLOGICA SINICA, 2017,Volume: 38,Issue: 11,Page: 1512-1520
Authors:  Jiang, Xiao-Ming;  Xu, Yu-Lian;  Huang, Mu-Yang;  Zhang, Le-Le;  Su, Min-Xia;  Chen, Xiuping;  Lu, Jin-Jian
Favorite |  | TC[WOS]:30 TC[Scopus]:30 | Submit date:2018/10/30
Non-small Cell Lung Cancer  Egfr  Osimertinib  Pd-l1  Ubiquitin-proteasome System  Mg-132  Bortezomib  Gsk3 Beta  Licl  
Reversal of paclitaxel resistance in human ovarian cancer cells with redox-responsive micelles consisting of alpha-tocopheryl succinate-based polyphosphoester copolymers Journal article
ACTA PHARMACOLOGICA SINICA, 2017,Volume: 38,Issue: 6,Page: 859-873
Authors:  Chen, Feng-qian;  Zhang, Jin-ming;  Fang, Xie-fan;  Yu, Hua;  Liu, Yu-ling;  Li, Hui;  Wang, Yi-tao;  Chen, Mei-wan
Favorite |  | TC[WOS]:14 TC[Scopus]:14 | Submit date:2018/10/30
Ovarian Carcinoma  Paclitaxel  Multidrug Resistance  Nanomedicines  D-alpha-tocopheryl Succinate  Redox-responsive Micelles  P-gp  Apoptosis  Cell Cycle Arrest  A2780/ptx Cells  
Reversal of paclitaxel resistance in human ovarian cancer cells with redox-responsive micelles consisting of α-Tocopheryl succinate-based polyphosphoester copolymers Journal article
Acta Pharmacologica Sinica, 2017,Volume: 38,Issue: 6,Page: 859
Authors:  Chen F.-Q.;  Zhang J.-M.;  Fang X.-F.;  Yu H.;  Liu Y.-L.;  Li H.;  Wang Y.-T.;  Chen M.-W.
Favorite |  | TC[WOS]:14 TC[Scopus]:14 | Submit date:2018/10/31
A2780/ptx Cells  Apoptosis  Cell Cycle Arrest  d-?-tocopheryl Succinate  Multidrug Resistance  Nanomedicines  Ovarian Carcinoma  P-gp  Paclitaxel  Redox-responsive Micelles