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Bromodomain and extra-terminal motif (BET) inhibition is synthetic lethal with loss of SMAD4 in colorectal cancer cells via restoring the loss of MYC repression Journal article
Oncogene, 2021,Volume: 40,Issue: 5,Page: 937-950
Authors:  Shi,Changxiang;  Yang,Eun Ju;  Liu,Yifan;  Mou,Pui Kei;  Ren,Guowen;  Shim,Joong Sup
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Modeling Uremic Vasculopathy With Induced Pluripotent Stem Cell-Derived Endothelial Cells as a Drug Screening System Journal article
Frontiers in Cell and Developmental Biology, 2021,Volume: 8
Authors:  Jang,Hye Ryoun;  Cho,Hyung Joon;  Zhou,Yang;  Shao,Ning Yi;  Lee,Kyungho;  Le,Hoai Huong Thi;  Jeon,Junseok;  Lee,Jung Eun;  Huh,Wooseong;  Ong,Sang Ging;  Lee,Won Hee;  Kim,Yoon Goo
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Chronic Kidney Disease  Endothelial Cells  Induced Pluripotent Stem Cells  Uremic Toxin  Uremic Vasculopathy  
In Vivo Screening of Xanthones from Garcinia oligantha Identified Oliganthin H as a Novel Natural Inhibitor of Convulsions Journal article
Journal of Natural Products, 2020,Volume: 83,Issue: 12,Page: 3706-3716
Authors:  Gong,Guiyi;  Chen,Hanbin;  Kam,Hiotong;  Chan,Ging;  Tang,Yue Xun;  Wu,Man;  Tan,Hongsheng;  Tse,Yu Chung;  Xu,Hong Xi;  Lee,Simon Ming Yuen
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Anti-COVID-19 drug screening: Frontier concepts and core technologies Journal article
Chinese Medicine (United Kingdom), 2020,Volume: 15,Issue: 1
Authors:  Luo,Hua;  Zhao,Mingming;  Tan,Dechao;  Liu,Chang;  Yang,Lin;  Qiu,Ling;  Gao,Yan;  Yu,Hua
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Core Technology  Covid-19  Disease Model  Traditional Chinese Medicine  
Enhanced Protein Damage Clearance Induces Broad Drug Resistance in Multitype of Cancers Revealed by an Evolution Drug-Resistant Model and Genome-Wide siRNA Screening Journal article
Advanced Science, 2020,Volume: 7,Issue: 23
Authors:  Shao,Fangyuan;  Lyu,Xueying;  Miao,Kai;  Xie,Lisi;  Wang,Haitao;  Xiao,Hao;  Li,Jie;  Chen,Qiang;  Ding,Renbo;  Chen,Ping;  Xing,Fuqiang;  Zhang,Xu;  Luo,Guang Hui;  Zhu,Wenli;  Cheng,Gregory;  Lon,Ng Wai;  Martin,Scott E.;  Wang,Guanyu;  Chen,Guokai;  Dai,Yunlu;  Deng,Chu Xia
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Broad Drug Resistance  Caspase 3 Activation  Patient-derived Organoid  Proteolysis  Rnai Screening  
The herbal extract deriving from aerial parts of Scutellaria baicalensis shows anti-inflammation and anti-hypoxia responses in cultured fin cells from rabbit fish Journal article
Fish and Shellfish Immunology, 2020,Volume: 106,Page: 71-78
Authors:  Xia,Yi Teng;  Hu,Wei Hui;  Wu,Qi Yun;  Dong,Tina Ting Xia;  Duan,Ran;  Xiao,Jian;  Li,Shao ping;  Qin,Qi Wei;  Wang,Wen Xiong;  Tsim,Karl Wah Keung
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Anti-hypoxia  Anti-inflammation  Cell line  Siganus fuscescens  Traditional Chinese medicine  
Interfering with S100B–effector protein interactions for cancer therapy Journal article
Drug Discovery Today, 2020,Volume: 25,Issue: 9,Page: 1754-1761
Authors:  Wu,Ke Jia;  Wang,Wanhe;  Wang,Hui Min David;  Leung,Chung Hang;  Ma,Dik Lung
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A Three-Way Combinatorial CRISPR Screen for Analyzing Interactions among Druggable Targets Journal article
Cell Reports, 2020,Volume: 32,Issue: 6
Authors:  Zhou,Peng;  Chan,Becky K.C.;  Wan,Yuk Kei;  Yuen,Chaya T.L.;  Choi,Gigi C.G.;  Li,Xinran;  Tong,Cindy S.W.;  Zhong,Sophia S.W.;  Sun,Jieran;  Bao,Yufan;  Mak,Silvia Y.L.;  Chow,Maggie Z.Y.;  Khaw,Jien Vei;  Leung,Suet Yi;  Zheng,Zongli;  Cheung,Lydia W.T.;  Tan,Kaeling;  Wong,Koon Ho;  Chan,H. Y.Edwin;  Wong,Alan S.L.
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Cancer  Combigem  Combination Therapy  Combinatorial Genetics  Crispr  Drug Interaction  Genetic Interaction  High-throughput Screening  Neurodegeneration  Parkinson's Disease  
Genomic characteristics and drug screening among organoids derived from non-small cell lung cancer patients Journal article
Thoracic Cancer, 2020,Volume: 11,Issue: 8,Page: 2279-2290
Authors:  Chen,Jing Hua;  Chu,Xiang Peng;  Zhang,Jia Tao;  Nie,Qiang;  Tang,Wen Fang;  Su,Jian;  Yan,Hong Hong;  Zheng,Hong Ping;  Chen,Ze Xin;  Chen,Xin;  Song,Meng Meng;  Yi,Xin;  Li,Pan Song;  Guan,Yan Fang;  Li,Gang;  Deng,Chu Xia;  Rosell,Rafael;  Wu,Yi Long;  Zhong,Wen Zhao
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Consistency analysis  drug screening  non-small cell lung cancer  patient-derived organoid  whole exome sequencing  
Deep-AmPEP30: Improve Short Antimicrobial Peptides Prediction with Deep Learning Journal article
Molecular Therapy - Nucleic Acids, 2020,Volume: 20,Page: 882-894
Authors:  Yan,Jielu;  Bhadra,Pratiti;  Li,Ang;  Sethiya,Pooja;  Qin,Longguang;  Tai,Hio Kuan;  Wong,Koon Ho;  Siu,Shirley W.I.
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AmPEP  ampicillin  antimicrobial peptide  AxPEP  Candida glabrata  convolutional neural network  drug discovery  machine learning  reduced amino acid composition