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Synthesis, biological evaluation and structure-activity relationship of novel dichloroacetophenones targeting pyruvate dehydrogenase kinases with potent anticancer activity Journal article
European Journal of Medicinal Chemistry, 2021,Volume: 214
Authors:  Xu,Biao;  Wang,Zhi Peng;  Liu,Qingwang;  Yang,Xiaohong;  Li,Xuemin;  Huang,Ding;  Qiu,Yanfei;  Tam,Kin Yip;  Zhang,Shao Lin;  He,Yun
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Cancer metabolism  Proliferation  Pyruvate dehydrogenase kinase  Structure-activity relationship  
Upregulation of amplified in breast cancer 1 contributes to pancreatic ductal adenocarcinoma progression and vulnerability to blockage of hedgehog activation Journal article
Theranostics, 2021,Volume: 11,Issue: 4,Page: 1672-1689
Authors:  Li,Licen;  Bao,Jiaolin;  Wang,Haitao;  Lei,Josh Haipeng;  Peng,Cheng;  Zeng,Jianming;  Hao,Wenhui;  Zhang,Xu;  Xu,Xiaoling;  Yu,Chundong;  Deng,Chu Xia;  Chen,Qiang
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Aib1  Ecm  Hedgehog  Mafb  Pdac  
Dissecting the mechanism of Yuzhi Zhixue granule on ovulatory dysfunctional uterine bleeding by network pharmacology and molecular docking Journal article
Chinese Medicine (United Kingdom), 2020,Volume: 15,Issue: 1
Authors:  Li,Jialin;  Luo,Hua;  Liu,Xinkui;  Zhang,Jingyuan;  Zhou,Wei;  Guo,Siyu;  Chen,Xiuping;  Liu,Yingying;  Jia,Shanshan;  Wang,Haojia;  Li,Bingbing;  Cheng,Guoliang;  Wu,Jiarui
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Mechanisms  Molecular Docking  Network pharmacology  Ovulatory Dysfunctional Uterine Bleeding  Yuzhi zhixue granule  
The role of autophagy in liver cancer: Crosstalk in signaling pathways and potential therapeutic targets Journal article
Pharmaceuticals, 2020,Volume: 13,Issue: 12,Page: 1-27
Authors:  Cui,Jianzhou;  Shen,Han Ming;  Lim,Lina Hsiu Kim
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AMPK  Autophagy  HCC  MAPK  MTOR  P53  ULK1  
Synthetic lethality of RB1 and aurora A is driven by stathmin-mediated disruption of microtubule dynamics Journal article
Nature Communications, 2020,Volume: 11,Issue: 1
Authors:  Lyu,Junfang;  Yang,Eun Ju;  Zhang,Baoyuan;  Wu,Changjie;  Pardeshi,Lakhansing;  Shi,Changxiang;  Mou,Pui Kei;  Liu,Yifan;  Tan,Kaeling;  Shim,Joong Sup
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Nanomedicines modulating tumor immunosuppressive cells to enhance cancer immunotherapy Journal article
Acta Pharmaceutica Sinica B, 2020,Volume: 10,Issue: 11,Page: 2054-2074
Authors:  Zhu,Yuefei;  Yu,Xiangrong;  Thamphiwatana,Soracha D.;  Zheng,Ying;  Pang,Zhiqing
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Cancer immunotherapy  Drug delivery  Nanomedicine  Tumor immunosuppressive microenvironment  
Transient receptor potential V1 (TRPV1) modulates the therapeutic effects for comorbidity of pain and depression: The common molecular implication for electroacupuncture and omega-3 polyunsaturated fatty acids Journal article
Brain, Behavior, and Immunity, 2020,Volume: 89,Page: 604-614
Authors:  Lin,Yi Wen;  Chou,Ana Isabel Wu;  Su,Huanxing;  Su,Kuan Pin
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Amygdala  Chronic pain  Depression  Inflammation  Prefrontal cortex  TRPV1  
Machado-Joseph Deubiquitinases: From Cellular Functions to Potential Therapy Targets Journal article
Frontiers in Pharmacology, 2020,Volume: 11
Authors:  Zeng,Chenming;  Zhao,Chenxi;  Ge,Fujing;  Li,Yuekang;  Cao,Ji;  Ying,Meidan;  Lu,Jinjian;  He,Qiaojun;  Yang,Bo;  Dai,Xiaoyang;  Zhu,Hong
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Cancer Therapy  Cellular Functions  Deubiquitinase  Machado-joseph Domain-containing Proteases  Mjd Disease  
A Three-Way Combinatorial CRISPR Screen for Analyzing Interactions among Druggable Targets Journal article
Cell Reports, 2020,Volume: 32,Issue: 6
Authors:  Zhou,Peng;  Chan,Becky K.C.;  Wan,Yuk Kei;  Yuen,Chaya T.L.;  Choi,Gigi C.G.;  Li,Xinran;  Tong,Cindy S.W.;  Zhong,Sophia S.W.;  Sun,Jieran;  Bao,Yufan;  Mak,Silvia Y.L.;  Chow,Maggie Z.Y.;  Khaw,Jien Vei;  Leung,Suet Yi;  Zheng,Zongli;  Cheung,Lydia W.T.;  Tan,Kaeling;  Wong,Koon Ho;  Chan,H. Y.Edwin;  Wong,Alan S.L.
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Cancer  Combigem  Combination Therapy  Combinatorial Genetics  Crispr  Drug Interaction  Genetic Interaction  High-throughput Screening  Neurodegeneration  Parkinson's Disease  
Dolichosin A, a coumestan isolated from Glycine tabacina, inhibits IL-1β-induced inflammation in SW982 human synovial cells and suppresses RANKL-induced osteoclastogenesis: From network pharmacology to experimental pharmacology Journal article
Journal of Ethnopharmacology, 2020,Volume: 258
Authors:  Tu,Yanbei;  Wang,Kai;  Tan,Lihua;  Han,Bing;  Hu,Yuanjia;  Ding,Hang;  He,Chengwei
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Dolichosin A  Glycine tabacina (Labill.) benth  Inflammation  Network pharmacology  Osteoclastogenesis  Rheumatoid arthritis