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9R, the cholinesterase and amyloid beta aggregation dual inhibitor, as a multifunctional agent to improve cognitive deficit and neuropathology in the triple-transgenic Alzheimer's disease mouse model Journal article
Neuropharmacology, 2020,Volume: 181
Authors:  Ju,Yaojun;  Tam,Kin Yip
Favorite |  | TC[WOS]:1 TC[Scopus]:1 | Submit date:2021/03/04
Alzheimer's disease  Amyloid beta  Cholinesterase  Dual inhibition  Multifunction  
Nitazoxanide, an anti-parasitic drug, efficiently ameliorates learning and memory impairments in AD model mice Journal article
ACTA PHARMACOLOGICA SINICA, 2019,Volume: 40,Issue: 10,Page: 1279-1291
Authors:  Lei Fan;  Xiao-xia Qiu;  Zhi-yuan Zhu;  Jian-lu Lv;  Jian Lu;  Fei Mao;  Jin Zhu;  Jia-ying Wang;  Xiao-wei Guan;  Jing Chen;  Jin Ren;  Ji-ming Ye;  Yong-hua Zhao;  Jian Li;  Xu Shen
Favorite |  | TC[WOS]:9 TC[Scopus]:11 | Submit date:2020/04/14
App/ps1 Transgenic Mice  Alzheimer’s Disease  Autophagy  Inflammation  Nitazoxanide  
SLOH, a carbazole-based fluorophore, mitigates neuropathology and behavioral impairment in the triple-transgenic mouse model of Alzheimer's disease Journal article
NEUROPHARMACOLOGY, 2018,Volume: 131,Page: 351-363
Authors:  Wu, Xiaoli;  Kosaraju, Jayasankar;  Zhou, Wei;  Tam, Kin Yip
Favorite |  | TC[WOS]:9 TC[Scopus]:9 | Submit date:2018/10/31
Amyloid beta  Aggregation  Alzheimer's disease  3xTg-AD  Neuroprotection  SH-SY5Y  
SLM, a novel carbazole-based fluorophore attenuates okadaic acid-induced tau hyperphosphorylation via down-regulating GSK-3 beta activity in SH-SY5Y cells Conference paper
Authors:  Wu, Xiaoli;  Kosaraju, Jayasankar;  Tam, Kin Yip
Favorite |  | TC[WOS]:10 TC[Scopus]:9 | Submit date:2018/10/30
Tau hyperphosphorylation  Alzheimer's disease  SLM  Okadaic acid  Glycogen synthase kinase-3 beta  
SLM, a novel carbazole-based fluorophore attenuates okadaic acid-induced tau hyperphosphorylation via down-regulating GSK-3β activity in SH-SY5Y cells Journal article
European Journal of Pharmaceutical Sciences, 2017,Volume: 110,Page: 101-108
Authors:  Wu X.;  Kosaraju J.;  Tam K.Y.
Favorite |  | TC[WOS]:10 TC[Scopus]:9 | Submit date:2018/12/18
Alzheimer's Disease  Glycogen Synthase Kinase-3β  Okadaic Acid  Slm  Tau Hyperphosphorylation  
Suppression of LPS-induced tau hyperphosphorylation by serum amyloid A Journal article
Journal of Neuroinflammation, 2016,Volume: 13,Issue: 1
Authors:  Liu J.;  Wang D.;  Li S.-Q.;  Yu Y.;  Ye R.D.
Favorite |  | TC[WOS]:21 TC[Scopus]:23 | Submit date:2018/11/07
Alzheimer's disease  Microglial activation  Serum amyloid A  Tau phosphorylation  
Deficiency of macrophage migration inhibitory factor attenuates tau hyperphosphorylation in mouse models of Alzheimer's disease Journal article
Journal of Neuroinflammation, 2015,Volume: 12,Issue: 1
Authors:  Li S.-Q.;  Yu Y.;  Han J.-Z.;  Wang D.;  Liu J.;  Qian F.;  Fan G.-H.;  Bucala R.;  Ye R.D.
Favorite |  | TC[WOS]:25 TC[Scopus]:24 | Submit date:2018/11/07
Alzheimer's disease  Astrocyte activation  Macrophage migration inhibitory factor  Tau phosphorylation  
Chemical and physical approaches for the treatment of Alzheimer's disease Journal article
ADMET and DMPK, 2015,Volume: 3,Issue: 3,Page: 216-234
Authors:  Li,Jing;  Zhou,Wei;  Wu,Xiaoli;  Tam,Kin
Favorite |  | TC[WOS]:2 TC[Scopus]:2 | Submit date:2021/03/04
Alzheimer's disease  Deep brain stimulation  Neurobiological pathogenesis  Pharmacological strategies  Tau protein  β-amyloid peptide  
Chemical and Physical Approaches for the Treatment of Alzheimer's Disease Journal article
ADMET & DMPK, 2015,Volume: 3,Issue: 3,Page: 216-234
Authors:  Jing Li;  WeiZhou;  Xiaoli Wu;  KinTam
Favorite |  | TC[WOS]:2 TC[Scopus]:2 | Submit date:2019/01/07
Alzheimer’s Disease  Β-amyloid Peptide  Tau Protein  Pharmacological Strategies  Deep Brain Stimulation  Neurobiological Pathogenesis  
Multi-Target Drugs: The Trend of Drug Research and Development Journal article
PLOS ONE, 2012,Volume: 7,Issue: 6,Page: 30-46
Authors:  Lu, JJ (Lu, Jin-Jian);  Pan, W (Pan, Wei);  Hu, YJ (Hu, Yuan-Jia);  Wang, YT (Wang, Yi-Tao
View | Adobe PDF | Favorite |  | TC[WOS]:124 TC[Scopus]:178 | Submit date:2018/11/01
Cancer-therapy  Alzheimers-disease  Parkinsons-disease  Attractive Target  Natural-products  b Inhibitors  Discovery  Atherosclerosis  Acetylcholinesterase  Proliferation