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Synthesis, biological evaluation and structure-activity relationship of novel dichloroacetophenones targeting pyruvate dehydrogenase kinases with potent anticancer activity Journal article
European Journal of Medicinal Chemistry, 2021,Volume: 214
Authors:  Xu，Biao;  Wang，Zhi Peng;  Liu，Qingwang;  Yang，Xiaohong;  Li，Xuemin;  Huang，Ding;  Qiu，Yanfei;  Tam，Kin Yip;  Zhang，Shao Lin;  He，Yun
Favorite |  | TC[WOS]:0 TC[Scopus]:0 | Submit date：2021/03/04
Cancer metabolism  Proliferation  Pyruvate dehydrogenase kinase  Structure-activity relationship  
In Vivo Screening of Xanthones from Garcinia oligantha Identified Oliganthin H as a Novel Natural Inhibitor of Convulsions Journal article
Journal of Natural Products, 2020,Volume: 83,Issue: 12,Page: 3706-3716
Authors:  Gong，Guiyi;  Chen，Hanbin;  Kam，Hiotong;  Chan，Ging;  Tang，Yue Xun;  Wu，Man;  Tan，Hongsheng;  Tse，Yu Chung;  Xu，Hong Xi;  Lee，Simon Ming Yuen
Favorite |  | TC[WOS]:0 TC[Scopus]:0 | Submit date：2021/03/01
Andrographolide derivative ameliorates dextran sulfate sodium-induced experimental colitis in mice Journal article
BIOCHEMICAL PHARMACOLOGY, 2019,Volume: 163,Page: 416-424
Authors:  Bao-Jian Guo;  Zhuyun Liu;  Mo-Yu Ding;  Feng Li;  Mei Jing;  Li-Peng Xu;  Yu-Qiang Wang;  Zai-Jun Zhang;  Yitao Wang;  Decai Wang;  Guo-Chun Zhou;  Ying Wang
Favorite |  | TC[WOS]:3 TC[Scopus]:4 | Submit date：2020/03/27
Andrographolide Analog  Colitis  Ibd  Nf-κb  Β-catenin  
An Integrated Transfer Learning and Multitask Learning Approach for Pharmacokinetic Parameter Prediction Journal article
Molecular Pharmaceutics, 2019,Volume: 16,Issue: 2,Page: 533-541
Authors:  Ye Z.;  Yang Y.;  Li X.;  Cao D.;  Ouyang D.
Favorite |  | TC[WOS]:10 TC[Scopus]:16 | Submit date：2019/02/14
Adme  Deep Learning  Multitask Learning  Pharmacokinetic Parameters  Transfer Learning  
Bioevaluation of Ranatuerin-2Pb from the Frog Skin Secretion of Rana pipiens and Its Truncated Analogues Journal article
BIOMOLECULES, 2019,Volume: 9,Issue: 6
Authors:  Xiaowei Zhou;  Daning Shi;  Ruimin Zhong;  Zhuming Ye;  Chengbang Ma;  Mei Zhou;  Xinping Xi;  Lei Wang;  Tianbao Chen;  Hang Fai Kwok
Favorite |  | TC[WOS]:7 TC[Scopus]:7 | Submit date：2020/05/20
Ranatuerin  Antimicrobial Peptides  Α-helix  Membrane Permeability  Waxworm Model  
Dichloroacetophenones targeting at pyruvate dehydrogenase kinase 1 with improved selectivity and antiproliferative activity: Synthesis and structure-activity relationships Journal article
Bioorganic and Medicinal Chemistry Letters, 2018,Volume: 28,Issue: 21,Page: 3441-3445
Authors:  Zhang，Shao Lin;  Yang，Zheng;  Hu，Xiaohui;  Tam，Kin Yip
Favorite |  | TC[WOS]:3 TC[Scopus]:3 | Submit date：2021/03/04
Antiproliferative activity  Dichloroacetophenone  Kinase inhibition  Pyruvate dehydrogenase complex  Pyruvate dehydrogenase kinase  
Dichloroacetophenones targeting at pyruvate dehydrogenase kinase 1 with improved selectivity and antiproliferative activity: Synthesis and structure-activity relationships Journal article
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2018,Volume: 28,Issue: 21,Page: 3441-3445
Authors:  Zhang, Shao-Lin;  Yang, Zheng;  Hu, Xiaohui;  Tam, Kin Yip
Favorite |  | TC[WOS]:3 TC[Scopus]:3 | Submit date：2018/10/30
Pyruvate dehydrogenase kinase  Pyruvate dehydrogenase complex  Antiproliferative activity  Dichloroacetophenone  Kinase inhibition  
Andrographolide derivative as STAT3 inhibitor that protects acute liver damage in mice Journal article
BIOORGANIC & MEDICINAL CHEMISTRY, 2018,Volume: 26,Issue: 18,Page: 5053-5061
Authors:  Chen, Shao-Ru;  Li, Feng;  Ding, Mo-Yu;  Wang, Decai;  Zhao, Qi;  Wang, Yitao;  Zhou, Guo-Chun;  Wang, Ying
View | Adobe PDF | Favorite |  | TC[WOS]:5 TC[Scopus]:7 | Submit date：2018/10/30
Andrographolide  Stat3 Inhibitor  Acute Liver Damage  Inflammation  
Synthetic Study toward the Total Synthesis of Taxezopidines A and B Journal article
ORGANIC LETTERS, 2018,Volume: 20,Issue: 18,Page: 5905-5909
Authors:  Hu, Ya-Jian;  Fan, Jian-Hong;  Li, Shaoping;  Zhao, Jing;  Li, Chuang-Chuang
View | Adobe PDF | Favorite |  | TC[WOS]:2 TC[Scopus]:2 | Submit date：2018/10/30
Overview of pharmacological activities of Andrographis paniculata and its major compound andrographolide Journal article
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION, 2018,Volume: 59,Page: S17-S29
Authors:  Yan Dai;  Shao-Ru Chen;  Ling Chai;  Jing Zhao;  Yitao Wang;  Ying Wang
Favorite |  | TC[WOS]:42 TC[Scopus]:37 | Submit date：2019/11/22
Andrographis Paniculata  Andrographolide  Mechanisms Of Action  Structureactivity-relationship