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Simultaneous blocking of the pan-RAF and S100B pathways as a synergistic therapeutic strategy against malignant melanoma
Journal article
Journal of Cellular and Molecular Medicine, 2021,Volume: 25,Issue: 4,Page: 1972-1981
Authors:
Wu,Ke Jia
;
Ho,Shih Hsin
;
Wu,Chun
;
Wang,Hui Min D.
;
Ma,Dik Lung
;
Leung,Chung Hang
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TC[WOS]:
0
TC[Scopus]:
0
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Submit date:2021/03/01
drug discovery
malignant melanoma
pan-RAF
S100B-p53 interaction
synergistic
Licochalcone A inhibits interferon-gamma-induced programmed death-ligand 1 in lung cancer cells
Journal article
Phytomedicine, 2021,Volume: 80
Authors:
Yuan,Luo Wei
;
Jiang,Xiao Ming
;
Xu,Yu Lian
;
Huang,Mu Yang
;
Chen,Yu Chi
;
Yu,Wei Bang
;
Su,Min Xia
;
Ye,Zi Han
;
Chen,Xiuping
;
Wang,Yitao
;
Lu,Jin Jian
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TC[WOS]:
0
TC[Scopus]:
0
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Submit date:2021/03/01
IFN-γ
Licochalcone A
Natural products
PD-L1
Protein synthesis inhibitor
ROS
Identification of nagilactone E as a protein synthesis inhibitor with anticancer activity
Journal article
Acta Pharmacologica Sinica, 2020,Volume: 41,Issue: 5,Page: 698-705
Authors:
Zhang,Le le
;
Guo,Jing
;
Jiang,Xiao ming
;
Chen,Xiu ping
;
Wang,Yi tao
;
Li,Ao
;
Lin,Li gen
;
Li,Hua
;
Lu,Jin jian
Favorite
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TC[WOS]:
6
TC[Scopus]:
6
|
Submit date:2021/03/01
Click-iT
CMap
diterpenoids
human lung cancer A549 cell line xenograft
molecular docking
nagilactone E
protein synthesis inhibitor
RIOK2
RNA-seq
Small molecule IVQ, as a prodrug of gluconeogenesis inhibitor QVO, efficiently ameliorates glucose homeostasis in type 2 diabetic mice
Journal article
ACTA PHARMACOLOGICA SINICA, 2019,Volume: 40,Issue: 9,Page: 1193-1204
Authors:
Ting-ting Zhou
;
Tong Zhao
;
Fei Ma
;
Yi-nan Zhang
;
Jing Jiang
;
Yuan Ruan
;
Qiu-ying Yan
;
Gai-hong Wang
;
Jin Ren
;
Xiao-wei Guan
;
Jun Guo
;
Yong-hua Zhao
;
Ji-ming Ye
;
Li-hong Hu
;
Jing Chen
;
Xu Shen
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TC[WOS]:
1
TC[Scopus]:
1
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Submit date:2020/04/14
Type 2 Diabetes Mellitus
Hepatic Gluconeogenesis
Ampk Signaling Pathway
(e)-3-(2-(Quinoline-4-yl)Vinyl)-1h-indol-6-ol (Qvo)
4-[2-(1h-indol-3-yl)Vinyl]Quinoline (Ivq)
Prodrug
Andrographolide derivative as STAT3 inhibitor that protects acute liver damage in mice
Journal article
BIOORGANIC & MEDICINAL CHEMISTRY, 2018,Volume: 26,Issue: 18,Page: 5053-5061
Authors:
Chen, Shao-Ru
;
Li, Feng
;
Ding, Mo-Yu
;
Wang, Decai
;
Zhao, Qi
;
Wang, Yitao
;
Zhou, Guo-Chun
;
Wang, Ying
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TC[WOS]:
5
TC[Scopus]:
6
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Submit date:2018/10/30
Andrographolide
Stat3 Inhibitor
Acute Liver Damage
Inflammation
Supramolecular strategy for reducing the cardiotoxicity of bedaquiline without compromising its antimycobacterial efficacy
Conference paper
FOOD AND CHEMICAL TOXICOLOGY, Kunming, PEOPLES R CHINA, AUG 25-30, 2018
Authors:
Kuok, Kit Ieng
;
Ng, Phoebe Choi In
;
Ji, Xia
;
Wang, Chunming
;
Yew, Wing Wai
;
Chan, Denise P. C.
;
Zheng, Jun
;
Lee, Simon M. Y.
;
Wang, Ruibing
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Adobe PDF
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TC[WOS]:
4
TC[Scopus]:
5
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Submit date:2018/10/30
Cucurbit[7]Uril
Bedaquiline
Supramolecular Formulation
Cardiotoxicity
Antimycobacterial
A novel Ca2+ current blocker promotes angiogenesis and cardiac healing after experimental myocardial infarction in mice
Journal article
PHARMACOLOGICAL RESEARCH, 2018,Volume: 134,Page: 109-117
Authors:
Cui, Guozhen
;
Xin, Qiqi
;
Tseng, Hisa Hui Ling
;
Hoi, Maggie PuiMan
;
Wang, Yan
;
Yang, Binrui
;
Choi, InLeng
;
Wang, Yuqiang
;
Yuan, Rong
;
Chen, Keji
;
Cong, Weihong
;
Lee, Simon MingYuen
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Adobe PDF
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Favorite
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TC[WOS]:
5
TC[Scopus]:
5
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Submit date:2018/10/30
Cardioprotection
Angiogenesis
ADTM
Zebrafish
VEGF
Downregulation of Cyclin B1 mediates nagilactone E-induced G2 phase cell cycle arrest in non-small cell lung cancer cells
Journal article
EUROPEAN JOURNAL OF PHARMACOLOGY, 2018,Volume: 830,Page: 17-25
Authors:
Zhang, Le-Le
;
Feng, Zhe-Ling
;
Su, Min-Xia
;
Jiang, Xiao-Ming
;
Chen, Xiuping
;
Wang, Yitao
;
Li, Ao
;
Lin, Li-Gen
;
Lu, Jin-Jian
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TC[WOS]:
21
TC[Scopus]:
20
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Submit date:2018/10/30
Nagilactone e
Non-small Cell Lung Cancer
Cyclin B1
Cell Cycle
Apoptosis
Physalin B induces cell cycle arrest and triggers apoptosis in breast cancer cells through modulating p53-dependent apoptotic pathway
Journal article
BIOMEDICINE & PHARMACOTHERAPY, 2018,Volume: 101,Page: 334-341
Authors:
Wang, Anqi
;
Wang, Shengpeng
;
Zhou, Fayang
;
Li, Peng
;
Wang, Yitao
;
Gan, Lishe
;
Lin, Ligen
View
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Adobe PDF
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Favorite
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TC[WOS]:
14
TC[Scopus]:
14
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Submit date:2018/10/30
Physalin b
Breast Cancer
Cell Cycle
Apoptosis
P53
Akt
Flavopiridol inhibits TGF-b-stimulated biglycan synthesis by blocking linker region phosphorylation and nuclear translocation of Smad2
Journal article
Journal of Pharmacology and Experimental Therapeutics, 2018,Volume: 365,Issue: 1,Page: 156-164
Authors:
Rostam M.A.
;
Shajimoon A.
;
Kamato D.
;
Mitra P.
;
Piva T.J.
;
Getachew R.
;
Cao Y.
;
Zheng W.
;
Osman N.
;
Little P.J.
Favorite
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TC[WOS]:
16
TC[Scopus]:
15
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Submit date:2018/12/21