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Shikonin promotes ubiquitination and degradation of cIAP1/2-mediated apoptosis and necrosis in triple negative breast cancer cells Journal article
Chinese Medicine (United Kingdom), 2021,Volume: 16,Issue: 1
Authors:  Wang,Anqi;  Liu,Jiayu;  Yang,Yuhan;  Chen,Zhejie;  Gao,Caifang;  Wang,Zhanguo;  Fu,Chaomei;  Zou,Liang;  Wang,Shengpeng
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Apoptosis  Breast Cancer  Necrosis  Shikonin  Ubiquitination  
A Destiny for Degradation: Interplay between Cullin-RING E3 Ligases and Autophagy Journal article
Trends in Cell Biology, 2021
Authors:  Lu,Guang;  Wang,Liming;  Zhou,Jing;  Liu,Wei;  Shen,Han Ming
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autophagy  cancer  cullin-RING E3 ligases  MTORC1  neddylation  ubiquitination  
Enhanced Protein Damage Clearance Induces Broad Drug Resistance in Multitype of Cancers Revealed by an Evolution Drug-Resistant Model and Genome-Wide siRNA Screening Journal article
Advanced Science, 2020,Volume: 7,Issue: 23
Authors:  Shao,Fangyuan;  Lyu,Xueying;  Miao,Kai;  Xie,Lisi;  Wang,Haitao;  Xiao,Hao;  Li,Jie;  Chen,Qiang;  Ding,Renbo;  Chen,Ping;  Xing,Fuqiang;  Zhang,Xu;  Luo,Guang Hui;  Zhu,Wenli;  Cheng,Gregory;  Lon,Ng Wai;  Martin,Scott E.;  Wang,Guanyu;  Chen,Guokai;  Dai,Yunlu;  Deng,Chu Xia
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Broad Drug Resistance  Caspase 3 Activation  Patient-derived Organoid  Proteolysis  Rnai Screening  
Acetyltanshinone IIA is more potent than lapatinib in inhibiting cell growth and degrading HER2 protein in drug-resistant HER2-positive breast cancer cells Journal article
Cancer Letters, 2020,Volume: 490,Page: 1-11
Authors:  Huang,Bin;  Yip,Wai Kien;  Wei,Na;  Luo,Kathy Qian
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Acetyltanshinone IIA  Drug resistance  HER2 degradation  HER2-positive breast cancer  
Oxyphylla a promotes degradation of α-synuclein for neuroprotection via activation of immunoproteasome Journal article
Aging and Disease, 2020,Volume: 11,Issue: 3,Page: 559-574
Authors:  Zhou,Hefeng;  Li,Shengnan;  Li,Chuwen;  Yang,Xuanjun;  Li,Haitao;  Zhong,Hanbing;  Lu,Jia Hong;  Lee,Simon Ming Yuen
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Degradation  Neuroprotection  Parkinson's disease  Proteasome  α-synuclein  
Organism dual RNA-seq reveals the importance of BarA/UvrY in Vibrio parahaemolyticus virulence Journal article
FASEB Journal, 2020,Volume: 34,Issue: 6,Page: 7561-7577
Authors:  Zhang W.;  Xie R.;  Zhang X.D.;  Lee L.T.O.;  Zhang H.;  Yang M.;  Peng B.;  Zheng J.
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Bara  C. Elegans  Organism Dual Rna-seq  Uvry  V. Parahaemolyticus  Virulence Factor  
Tetramethylpyrazine Analogue T-006 Promotes the Clearance of Alpha-synuclein by Enhancing Proteasome Activity in Parkinson’s Disease Models Journal article
Neurotherapeutics, 2019,Volume: 16,Issue: 4,Page: 1225-1236
Authors:  Zhou,Hefeng;  Shao,Min;  Guo,Baojian;  Li,Chuwen;  Lu,Yucong;  Yang,Xuanjun;  ShengnanLi,;  Li,Haitao;  Zhu,Qi;  Zhong,Hanbing;  Wang,Yuqiang;  Zhang,Zaijun;  Lu,Jiahong;  Lee,Simon Ming Yuen
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Degradation  LMP7  Parkinson’s disease  Proteasome activity  α-synuclein  
Natural alkaloid harmine promotes degradation of alpha-synuclein via PKA-mediated ubiquitin-proteasome system activation Journal article
Phytomedicine, 2019,Volume: 61
Authors:  Cai,Cui Zan;  Zhou,He Feng;  Yuan,Ning Ning;  Wu,Ming Yue;  Lee,Simon Ming Yuen;  Ren,Jiao Yan;  Su,Huan Xing;  Lu,Jin Jian;  Chen,Xiu Ping;  Li,Min;  Tan,Jie Qiong;  Lu,Jia Hong
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-synuclein  Harmine  Parkinson's disease  Protein kinase A  Ubiquitin-proteasome system  
Canthin-6-One Accelerates Alpha-Synuclein Degradation by Enhancing UPS Activity: Drug Target Identification by CRISPR-Cas9 Whole Genome-Wide Screening Technology Journal article
FRONTIERS IN PHARMACOLOGY, 2019
Authors:  Ning-Ning Yuan;  Cui-Zan Cai;  Ming-Yue Wu;  Qi Zhu;  HuanXing Su;  Min Li;  JiaoYan Ren;  Jie-Qiong Tan;  Jia-Hong Lu
Favorite |  | TC[WOS]:5 TC[Scopus]:6 | Submit date:2020/04/14
Canthin-6-one  Parkinson’s Disease  Alpha-synuclein  Ubiquitin-proteasome-system  Crispr/cas9  Rpn2/psmd1  Pka  
MK2 mediates macrophage activation and acute lung injury by regulating let-7e miRNA Journal article
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY, 2018,Volume: 315,Issue: 3,Page: L371-L381
Authors:  Wu, Yaxian;  He, Huiqiong;  Ding, Yunhe;  Liu, Sirui;  Zhang, Depeng;  Wang, Jun;  Jiang, Hongchao;  Zhang, Dan;  Sun, Lei;  Ye, Richard D.;  Qian, Feng
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acute lung injury  let-7e  lipopolysaccharides  macrophage  MAPK-activated protein kinase 2  miRNA  MK2