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Artemisinin protects motoneurons against axotomy-induced apoptosis through activation of the PKA-Akt signaling pathway and promotes neural stem/progenitor cells differentiation into NeuN+ neurons Journal article
Pharmacological Research, 2020,Volume: 159
Authors:  Liu,Linlin;  Zhao,Xia;  Silva,Marta;  Li,Shuai;  Xing,Xingan;  Zheng,Wenhua
Favorite |  | TC[WOS]:0 TC[Scopus]:0 | Submit date:2021/03/04
Artemisinin  Brachial plexus axotomy  Inflammatory response  Motoneurons  
Oxyphylla a promotes degradation of α-synuclein for neuroprotection via activation of immunoproteasome Journal article
Aging and Disease, 2020,Volume: 11,Issue: 3,Page: 559-574
Authors:  Zhou,Hefeng;  Li,Shengnan;  Li,Chuwen;  Yang,Xuanjun;  Li,Haitao;  Zhong,Hanbing;  Lu,Jia Hong;  Lee,Simon Ming Yuen
Favorite |  | TC[WOS]:1 TC[Scopus]:1 | Submit date:2021/03/01
Degradation  Neuroprotection  Parkinson's disease  Proteasome  α-synuclein  
Transcriptome analysis of peripheral whole blood identifies crucial lncRNAs implicated in childhood asthma Journal article
BMC Medical Genomics, 2020,Volume: 13,Issue: 1
Authors:  Zheng P.;  Huang C.;  Leng D.;  Sun B.;  Zhang X.D.
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Childhood Asthma  Deep Rna-sequencing  Long Non-coding Rnas  Transcriptome  
Tetramethylpyrazine Analogue T-006 Promotes the Clearance of Alpha-synuclein by Enhancing Proteasome Activity in Parkinson’s Disease Models Journal article
Neurotherapeutics, 2019,Volume: 16,Issue: 4,Page: 1225-1236
Authors:  Zhou,Hefeng;  Shao,Min;  Guo,Baojian;  Li,Chuwen;  Lu,Yucong;  Yang,Xuanjun;  ShengnanLi,;  Li,Haitao;  Zhu,Qi;  Zhong,Hanbing;  Wang,Yuqiang;  Zhang,Zaijun;  Lu,Jiahong;  Lee,Simon Ming Yuen
Favorite |  | TC[WOS]:7 TC[Scopus]:7 | Submit date:2021/03/01
Degradation  LMP7  Parkinson’s disease  Proteasome activity  α-synuclein  
Natural alkaloid harmine promotes degradation of alpha-synuclein via PKA-mediated ubiquitin-proteasome system activation Journal article
Phytomedicine, 2019,Volume: 61
Authors:  Cai,Cui Zan;  Zhou,He Feng;  Yuan,Ning Ning;  Wu,Ming Yue;  Lee,Simon Ming Yuen;  Ren,Jiao Yan;  Su,Huan Xing;  Lu,Jin Jian;  Chen,Xiu Ping;  Li,Min;  Tan,Jie Qiong;  Lu,Jia Hong
Favorite |  | TC[WOS]:9 TC[Scopus]:8 | Submit date:2021/03/01
-synuclein  Harmine  Parkinson's disease  Protein kinase A  Ubiquitin-proteasome system  
A Cucurbit[8]uril2:2 Complex with a Negative pKa Shift Journal article
CHEMISTRY-A EUROPEAN JOURNAL, 2019,Volume: 25,Issue: 54,Page: 12552-12559
Authors:  Hang Yin;  Qian Cheng;  Roselyne Rosas;  StØphane Viel;  ValØrie Monnier;  Laurence Charles;  Didier Siri;  Didier Gigmes;  Olivier Ouari;  Ruibing Wang;  Anthony Kermagoret;  David Bardelang
Favorite |  | TC[WOS]:7 TC[Scopus]:6 | Submit date:2020/04/03
2:2complexes  Cucurbituril  Host–guestsystems  Imidazoles  Viologen  
Neuroprotective Effects of BHDPC, a Novel Neuroprotectant, on Experimental Stroke by Modulating Microglia Polarization Journal article
ACS CHEMICAL NEUROSCIENCE, 2019,Volume: 10,Issue: 5,Page: 2434-2449
Authors:  Chuwen Li;  Yaqi Bian;  Yu Feng;  Fan Tang;  Liang Wang;  Maggie Pui Man Hoi;  Dan Ma;  Chao Zhao;  Simon Ming Yuen Lee
Favorite |  | TC[WOS]:11 TC[Scopus]:11 | Submit date:2020/01/16
Bhdpc  Ischemic Stroke  Microglia  Nf-κb  Creb  Pka  
Novel protective effect of O-1602 and abnormal cannabidiol, GPR55 agonists, on ER stress-induced apoptosis in pancreatic β-cells Journal article
Biomedicine and Pharmacotherapy, 2019,Volume: 111,Page: 1176-1186
Authors:  Vong,Chi Teng;  Tseng,Hisa Hui Ling;  Kwan,Yiu Wa;  Lee,Simon Ming Yuen;  Hoi,Maggie Pui Man
Favorite |  | TC[WOS]:6 TC[Scopus]:7 | Submit date:2021/03/01
CREB  ER stress  GPR55  β-Cell apoptosis  
Tetramethylpyrazine Analogue T-006 Exerts Neuroprotective Effects against 6-Hydroxydopamine-Induced Parkinson's Disease In Vitro and In Vivo Journal article
Oxidative Medicine and Cellular Longevity, 2019,Volume: 2019
Authors:  Zhou,Hefeng;  Shao,Min;  Yang,Xuanjun;  Li,Chuwen;  Cui,Guozhen;  Gao,Cheng;  Di,Lijun;  Zhong,Hanbing;  Wang,Yuqiang;  Zhang,Zaijun;  Lee,Simon Ming Yuen
Favorite |  | TC[WOS]:5 TC[Scopus]:5 | Submit date:2021/03/01
Canthin-6-One Accelerates Alpha-Synuclein Degradation by Enhancing UPS Activity: Drug Target Identification by CRISPR-Cas9 Whole Genome-Wide Screening Technology Journal article
FRONTIERS IN PHARMACOLOGY, 2019
Authors:  Ning-Ning Yuan;  Cui-Zan Cai;  Ming-Yue Wu;  Qi Zhu;  HuanXing Su;  Min Li;  JiaoYan Ren;  Jie-Qiong Tan;  Jia-Hong Lu
Favorite |  | TC[WOS]:5 TC[Scopus]:6 | Submit date:2020/04/14
Canthin-6-one  Parkinson’s Disease  Alpha-synuclein  Ubiquitin-proteasome-system  Crispr/cas9  Rpn2/psmd1  Pka