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Synthesis, biological evaluation and structure-activity relationship of novel dichloroacetophenones targeting pyruvate dehydrogenase kinases with potent anticancer activity Journal article
European Journal of Medicinal Chemistry, 2021,Volume: 214
Authors:  Xu,Biao;  Wang,Zhi Peng;  Liu,Qingwang;  Yang,Xiaohong;  Li,Xuemin;  Huang,Ding;  Qiu,Yanfei;  Tam,Kin Yip;  Zhang,Shao Lin;  He,Yun
Favorite |  | TC[WOS]:0 TC[Scopus]:0 | Submit date:2021/03/04
Cancer metabolism  Proliferation  Pyruvate dehydrogenase kinase  Structure-activity relationship  
Adsorbed hollow fiber immobilized tyrosinase for the screening of enzyme inhibitors from Pueraria lobata extract Journal article
Journal of Pharmaceutical and Biomedical Analysis, 2021,Volume: 193
Authors:  Zhao,Cong Peng;  Yin,Shi Jun;  Chen,Guo Ying;  Wang,Yuan;  Chen,Hua;  Zhao,Jing;  Yang,Feng Qing
Favorite |  | TC[WOS]:0 TC[Scopus]:0 | Submit date:2021/03/02
Adsorbed hollow fibers  Enzyme immobilization  Inhibitor screening  Pueraria lobata  Tyrosinase  
Dissecting the mechanism of Yuzhi Zhixue granule on ovulatory dysfunctional uterine bleeding by network pharmacology and molecular docking Journal article
Chinese Medicine (United Kingdom), 2020,Volume: 15,Issue: 1
Authors:  Li,Jialin;  Luo,Hua;  Liu,Xinkui;  Zhang,Jingyuan;  Zhou,Wei;  Guo,Siyu;  Chen,Xiuping;  Liu,Yingying;  Jia,Shanshan;  Wang,Haojia;  Li,Bingbing;  Cheng,Guoliang;  Wu,Jiarui
Favorite |  | TC[WOS]:0 TC[Scopus]:1 | Submit date:2021/03/01
Mechanisms  Molecular Docking  Network pharmacology  Ovulatory Dysfunctional Uterine Bleeding  Yuzhi zhixue granule  
Anti-COVID-19 drug screening: Frontier concepts and core technologies Journal article
Chinese Medicine (United Kingdom), 2020,Volume: 15,Issue: 1
Authors:  Luo,Hua;  Zhao,Mingming;  Tan,Dechao;  Liu,Chang;  Yang,Lin;  Qiu,Ling;  Gao,Yan;  Yu,Hua
Favorite |  | TC[WOS]:3 TC[Scopus]:4 | Submit date:2021/03/02
Core Technology  Covid-19  Disease Model  Traditional Chinese Medicine  
Characterization of thrombin/factor Xa inhibitors in Rhizoma Chuanxiong through UPLC-MS-based multivariate statistical analysis Journal article
Chinese Medicine (United Kingdom), 2020,Volume: 15,Issue: 1
Authors:  Yang,Yi Yao;  Wu,Zhao Yu;  Xia,Fang Bo;  Zhang,Hao;  Wang,Xu;  Gao,Jian Li;  Yang,Feng Qing;  Wan,Jian Bo
Favorite |  | TC[WOS]:2 TC[Scopus]:3 | Submit date:2021/03/02
Chuanxiong  Enzyme inhibitor  Factor Xa  Molecular docking  Multivariate statistical analysis  Thrombin  
Identification of nagilactone E as a protein synthesis inhibitor with anticancer activity Journal article
Acta Pharmacologica Sinica, 2020,Volume: 41,Issue: 5,Page: 698-705
Authors:  Zhang,Le le;  Guo,Jing;  Jiang,Xiao ming;  Chen,Xiu ping;  Wang,Yi tao;  Li,Ao;  Lin,Li gen;  Li,Hua;  Lu,Jin jian
Favorite |  | TC[WOS]:6 TC[Scopus]:6 | Submit date:2021/03/01
Click-iT  CMap  diterpenoids  human lung cancer A549 cell line xenograft  molecular docking  nagilactone E  protein synthesis inhibitor  RIOK2  RNA-seq  
LC-MS-based multivariate statistical analysis for the screening of potential thrombin/factor Xa inhibitors from Radix Salvia Miltiorrhiza Journal article
Chinese Medicine (United Kingdom), 2020,Volume: 15,Issue: 1
Authors:  Yang,Yi Yao;  Wu,Zhao Yu;  Zhang,Hao;  Yin,Shi Jun;  Xia,Fang Bo;  Zhang,Qian;  Wan,Jian Bo;  Gao,Jian Li;  Yang,Feng Qing
Favorite |  | TC[WOS]:1 TC[Scopus]:3 | Submit date:2021/03/02
Factor Xa  Inhibitor screening  Molecular docking  Multivariate statistical analysis  Radix Salvia Miltiorrhiza  Thrombin  
Coupled genome-wide DNA methylation and transcription analysis identified rich biomarkers and drug targets in triple-negative breast cancer Journal article
Cancers, 2019,Volume: 11,Issue: 11
Authors:  Guo,Maoni;  Sinha,Siddharth;  Wang,San Ming
Favorite |  | TC[WOS]:2 TC[Scopus]:2 | Submit date:2021/03/02
DNA methylation  Gene expression  Therapeutic targets  TNBC  
Anti-inflammatory activities of Sigesbeckia glabrescens Makino: combined in vitro and in silico investigations Journal article
CHINESE MEDICINE, 2019,Volume: 14,Issue: 1
Authors:  Zhangfeng Zhong;  Qianru Zhang;  Hongxun Tao;  Wei Sang;  Liao Cui;  Wenan Qiang;  Wai San Cheang;  Yuanjia Hu;  Hua Yu;  Yitao Wang
Favorite |  | TC[WOS]:7 TC[Scopus]:8 | Submit date:2019/11/22
Sigesbeckia Glabrescens Makino  Infammation  Lipopolysaccharide  Docking  Tlr4  Nf-κb  
Identification of novel oligopeptides from the simulated digestion of sea cucumber (Stichopus japonicus) to alleviate Aβ aggregation progression Journal article
Journal of Functional Foods, 2019,Volume: 60
Authors:  Lin,Xiaoling;  Yao,Maojin;  Lu,Jia Hong;  Wang,Yi;  Yin,Xiquan;  Liang,Ming;  Yuan,Erdong;  Ren,Jiaoyan
Favorite |  | TC[WOS]:2 TC[Scopus]:2 | Submit date:2021/03/02
Anti-Aβ aggregation activity  Antioxidant activity  Identification  Purification  Sea cucumber (Stichopus japonicus)  Simulated gastrointestinal digestion