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Synthesis, biological evaluation and structure-activity relationship of novel dichloroacetophenones targeting pyruvate dehydrogenase kinases with potent anticancer activity Journal article
European Journal of Medicinal Chemistry, 2021,Volume: 214
Authors:  Xu,Biao;  Wang,Zhi Peng;  Liu,Qingwang;  Yang,Xiaohong;  Li,Xuemin;  Huang,Ding;  Qiu,Yanfei;  Tam,Kin Yip;  Zhang,Shao Lin;  He,Yun
Favorite |  | TC[WOS]:0 TC[Scopus]:0 | Submit date:2021/03/04
Cancer metabolism  Proliferation  Pyruvate dehydrogenase kinase  Structure-activity relationship  
Function of DHX33 in promoting Warburg effect via regulation of glycolytic genes Journal article
Journal of Cellular Physiology, 2021,Volume: 236,Issue: 2,Page: 981-996
Authors:  Peng,Cheng;  Hou,Sheng Tao;  Deng,Chu Xia;  Zhang,Yandong
Favorite |  | TC[WOS]:0 TC[Scopus]:0 | Submit date:2021/03/02
demethylation  DHX33  Gadd45a  glycolysis  RNA helicase  Warburg effect  
Development of dual inhibitors targeting pyruvate dehydrogenase kinases and human lactate dehydrogenase A: High-throughput virtual screening, synthesis and biological validation Journal article
European Journal of Medicinal Chemistry, 2020,Volume: 203
Authors:  Xiang,Sichuan;  Huang,Ding;  He,Qiaolin;  Li,Jie;  Tam,Kin Yip;  Zhang,Shao Lin;  He,Yun
Favorite |  | TC[WOS]:2 TC[Scopus]:2 | Submit date:2021/03/04
Cancer metabolism  Cancer proliferation  Dual inhibitor  Lactate dehydrogenase A  Pyruvate dehydrogenase kinase  
An integrative multi-omics approach uncovers the regulatory role of CDK7 and CDK4 in autophagy activation induced by silica nanoparticles Journal article
Autophagy, 2020
Authors:  Ruan,Chen;  Wang,Chenwei;  Gong,Xuanqing;  Zhang,Ying;  Deng,Wankun;  Zhou,Jiaqi;  Huang,Dengtong;  Wang,Zining;  Zhang,Qiong;  Guo,Anyuan;  Lu,Jiahong;  Gao,Jinhao;  Peng,Di;  Xue,Yu
Favorite |  | TC[WOS]:4 TC[Scopus]:4 | Submit date:2021/03/02
Autophagy  CDK4  CDK7  phosphoproteomics  protein kinase  silica nanoparticles  
Organism dual RNA-seq reveals the importance of BarA/UvrY in Vibrio parahaemolyticus virulence Journal article
FASEB Journal, 2020,Volume: 34,Issue: 6,Page: 7561-7577
Authors:  Zhang W.;  Xie R.;  Zhang X.D.;  Lee L.T.O.;  Zhang H.;  Yang M.;  Peng B.;  Zheng J.
Adobe PDF | Favorite |  | TC[WOS]:0 TC[Scopus]:0 | Submit date:2021/03/03
Bara  C. Elegans  Organism Dual Rna-seq  Uvry  V. Parahaemolyticus  Virulence Factor  
Protective mechanism of artemisinin on rat bone marrow-derived mesenchymal stem cells against apoptosis induced by hydrogen peroxide via activation of c-Raf-Erk1/2-p90rsk-CREB pathway Journal article
Stem Cell Research and Therapy, 2019,Volume: 10,Issue: 1
Authors:  Fang,Jiankang;  Zhao,Xia;  Li,Shuai;  Xing,Xingan;  Wang,Haitao;  Lazarovici,Philip;  Zheng,Wenhua
Favorite |  | TC[WOS]:12 TC[Scopus]:11 | Submit date:2021/03/04
Apoptosis  Artemisinin  Bone marrow mesenchymal stem cells  CREB  Erk1/2  p90rsk  Phosphorylation  Protection  Raf  ROS  
Anti-inflammatory activities of Sigesbeckia glabrescens Makino: combined in vitro and in silico investigations Journal article
CHINESE MEDICINE, 2019,Volume: 14,Issue: 1
Authors:  Zhangfeng Zhong;  Qianru Zhang;  Hongxun Tao;  Wei Sang;  Liao Cui;  Wenan Qiang;  Wai San Cheang;  Yuanjia Hu;  Hua Yu;  Yitao Wang
Favorite |  | TC[WOS]:9 TC[Scopus]:9 | Submit date:2019/11/22
Sigesbeckia Glabrescens Makino  Infammation  Lipopolysaccharide  Docking  Tlr4  Nf-κb  
Metformin protects PC12 cells and hippocampal neurons from H2O (2)-induced oxidative damage through activation of AMPK pathway Journal article
JOURNAL OF CELLULAR PHYSIOLOGY, 2019,Volume: 234,Issue: 9,Page: 16619-16629
Authors:  Xia Zhao;  Zhiwen Zeng;  Uma Gaur;  Jiankang Fang;  Tangming Peng;  Shuai Li;  Wenhua Zheng
Favorite |  | TC[WOS]:14 TC[Scopus]:13 | Submit date:2020/06/11
Aging  Amp-activated Protein Kinase  Hydrogen Peroxide  Metformin  Pc12 Cells  
Shengui Sansheng San Ameliorates Cerebral Energy Deficiency via Citrate Cycle After Ischemic Stroke Journal article
FRONTIERS IN PHARMACOLOGY, 2019,Volume: 10
Authors:  Cheng Luo;  Xiqing Bian;  Qian Zhang;  Zhenyan Xia;  Bowen Liu;  Qi Chen;  Chienchih Ke;  Jian-Lin Wu;  Yonghua Zhao
Favorite |  | TC[WOS]:7 TC[Scopus]:8 | Submit date:2020/04/14
Cerebral Energy Deficiency  Citrate Cycle  Diaaa Derivatization-uhplc-q-tof/ms  Ischemic Stroke  Shengui Sansheng San  
Anticancer effects of some novel dichloroacetophenones through the inhibition of pyruvate dehydrogenase kinase 1 Journal article
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, 2018,Volume: 123,Page: 43-55
Authors:  Zhang, Shao-Lin;  Yang, Zheng;  Hu, Xiaohui;  Chakravarty, Harapriya;  Tam, Kin Yip
Favorite |  | TC[WOS]:7 TC[Scopus]:7 | Submit date:2018/10/30
Dichloroacetophenone  Pyruvate Dehydrogenase Kinase  Pyruvate Dehydrogenase Complex  Anticancer Activity  Metabolic Reprogramming