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Bromodomain and extra-terminal motif (BET) inhibition is synthetic lethal with loss of SMAD4 in colorectal cancer cells via restoring the loss of MYC repression Journal article
Oncogene, 2021,Volume: 40,Issue: 5,Page: 937-950
Authors:  Shi,Changxiang;  Yang,Eun Ju;  Liu,Yifan;  Mou,Pui Kei;  Ren,Guowen;  Shim,Joong Sup
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Adsorbed hollow fiber immobilized tyrosinase for the screening of enzyme inhibitors from Pueraria lobata extract Journal article
Journal of Pharmaceutical and Biomedical Analysis, 2021,Volume: 193
Authors:  Zhao,Cong Peng;  Yin,Shi Jun;  Chen,Guo Ying;  Wang,Yuan;  Chen,Hua;  Zhao,Jing;  Yang,Feng Qing
Favorite |  | TC[WOS]:3 TC[Scopus]:3 | Submit date:2021/03/02
Adsorbed Hollow Fibers  Enzyme Immobilization  Inhibitor Screening  Pueraria Lobata  Tyrosinase  
A 7-methoxybicoumarin derivative selectively inhibits BRD4 BD2 for anti-melanoma therapy Journal article
International Journal of Biological Macromolecules, 2020,Volume: 164,Page: 3204-3220
Authors:  Yang,Guan Jun;  Wang,Wanhe;  Lei,Pui Man;  Leung,Chung Hang;  Ma,Dik Lung
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Brd4  BromoDomain Domain  Cell Metastasis And Invasion  Histone Acetylation  Melanoma  Protein–protein Interaction  Virtual Screening  
In Vivo Screening of Xanthones from Garcinia oligantha Identified Oliganthin H as a Novel Natural Inhibitor of Convulsions Journal article
Journal of Natural Products, 2020,Volume: 83,Issue: 12,Page: 3706-3716
Authors:  Gong,Guiyi;  Chen,Hanbin;  Kam,Hiotong;  Chan,Ging;  Tang,Yue Xun;  Wu,Man;  Tan,Hongsheng;  Tse,Yu Chung;  Xu,Hong Xi;  Lee,Simon Ming Yuen
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Enhanced Protein Damage Clearance Induces Broad Drug Resistance in Multitype of Cancers Revealed by an Evolution Drug-Resistant Model and Genome-Wide siRNA Screening Journal article
Advanced Science, 2020,Volume: 7,Issue: 23
Authors:  Shao,Fangyuan;  Lyu,Xueying;  Miao,Kai;  Xie,Lisi;  Wang,Haitao;  Xiao,Hao;  Li,Jie;  Chen,Qiang;  Ding,Renbo;  Chen,Ping;  Xing,Fuqiang;  Zhang,Xu;  Luo,Guang Hui;  Zhu,Wenli;  Cheng,Gregory;  Lon,Ng Wai;  Martin,Scott E.;  Wang,Guanyu;  Chen,Guokai;  Dai,Yunlu;  Deng,Chu Xia
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Broad Drug Resistance  Caspase 3 Activation  Patient-derived Organoid  Proteolysis  Rnai Screening  
Structure-guided discovery of a luminescent theranostic toolkit for living cancer cells and the imaging behavior effect Journal article
Chemical Science, 2020,Volume: 11,Issue: 42,Page: 11404-11412
Authors:  Wu,Chun;  Wu,Ke Jia;  Liu,Jin Biao;  Wang,Wanhe;  Leung,Chung Hang;  Ma,Dik Lung
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Development of dual inhibitors targeting pyruvate dehydrogenase kinases and human lactate dehydrogenase A: High-throughput virtual screening, synthesis and biological validation Journal article
European Journal of Medicinal Chemistry, 2020,Volume: 203
Authors:  Xiang,Sichuan;  Huang,Ding;  He,Qiaolin;  Li,Jie;  Tam,Kin Yip;  Zhang,Shao Lin;  He,Yun
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Cancer metabolism  Cancer proliferation  Dual inhibitor  Lactate dehydrogenase A  Pyruvate dehydrogenase kinase  
Interfering with S100B–effector protein interactions for cancer therapy Journal article
Drug Discovery Today, 2020,Volume: 25,Issue: 9,Page: 1754-1761
Authors:  Wu,Ke Jia;  Wang,Wanhe;  Wang,Hui Min David;  Leung,Chung Hang;  Ma,Dik Lung
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Aspergillus fumigatus transcription factors involved in the caspofungin paradoxical effect Journal article
mBio, 2020,Volume: 11,Issue: 3,Page: 1-22
Authors:  Valero,Clara;  Colabardini,Ana Cristina;  Chiaratto,Jéssica;  Pardeshi,Lakhansing;  de Castro,Patrícia Alves;  Filho,Jaire Alves Ferreira;  Silva,Lilian Pereira;  Rocha,Marina Campos;  Malavazi,Iran;  Costa,Jonas Henrique;  Fill,Taícia;  Barros,Mário Henrique;  Wong,Sarah Sze Wah;  Aimanianda,Vishukumar;  Wong,Koon Ho;  Goldman,Gustavo H.
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Aspergillus fumigatus  Calcium  Caspofungin  Cell wall  Mitochondria  Transcription factors  
LC-MS-based multivariate statistical analysis for the screening of potential thrombin/factor Xa inhibitors from Radix Salvia Miltiorrhiza Journal article
Chinese Medicine (United Kingdom), 2020,Volume: 15,Issue: 1
Authors:  Yang,Yi Yao;  Wu,Zhao Yu;  Zhang,Hao;  Yin,Shi Jun;  Xia,Fang Bo;  Zhang,Qian;  Wan,Jian Bo;  Gao,Jian Li;  Yang,Feng Qing
Favorite |  | TC[WOS]:1 TC[Scopus]:3 | Submit date:2021/03/02
Factor Xa  Inhibitor Screening  Molecular Docking  Multivariate Statistical Analysis  Radix Salvia Miltiorrhiza  Thrombin