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9R, the cholinesterase and amyloid beta aggregation dual inhibitor, as a multifunctional agent to improve cognitive deficit and neuropathology in the triple-transgenic Alzheimer's disease mouse model Journal article
Neuropharmacology, 2020,Volume: 181
Authors:  Ju,Yaojun;  Tam,Kin Yip
Favorite |  | TC[WOS]:1 TC[Scopus]:1 | Submit date:2021/03/04
Alzheimer's disease  Amyloid beta  Cholinesterase  Dual inhibition  Multifunction  
Structure-guided discovery of a luminescent theranostic toolkit for living cancer cells and the imaging behavior effect Journal article
Chemical Science, 2020,Volume: 11,Issue: 42,Page: 11404-11412
Authors:  Wu,Chun;  Wu,Ke Jia;  Liu,Jin Biao;  Wang,Wanhe;  Leung,Chung Hang;  Ma,Dik Lung
Favorite |  | TC[WOS]:2 TC[Scopus]:2 | Submit date:2021/03/01
An Isoquinolinium Dual Inhibitor of Cholinesterases and Amyloid β Aggregation Mitigates Neuropathological Changes in a Triple-Transgenic Mouse Model of Alzheimer's Disease Journal article
ACS Chemical Neuroscience, 2020,Volume: 11,Issue: 20,Page: 3346-3357
Authors:  Ju,Yaojun;  Chakravarty,Harapriya;  Tam,Kin Yip
Favorite |  | TC[WOS]:0 TC[Scopus]:0 | Submit date:2021/03/04
Alzheimer's disease  amyloid beta  cholinesterase  dual inhibition  
Development of dual inhibitors targeting pyruvate dehydrogenase kinases and human lactate dehydrogenase A: High-throughput virtual screening, synthesis and biological validation Journal article
European Journal of Medicinal Chemistry, 2020,Volume: 203
Authors:  Xiang,Sichuan;  Huang,Ding;  He,Qiaolin;  Li,Jie;  Tam,Kin Yip;  Zhang,Shao Lin;  He,Yun
Favorite |  | TC[WOS]:2 TC[Scopus]:2 | Submit date:2021/03/04
Cancer metabolism  Cancer proliferation  Dual inhibitor  Lactate dehydrogenase A  Pyruvate dehydrogenase kinase  
Dual targeting of cholinesterase and amyloid beta with pyridinium/isoquinolium derivatives Journal article
Drug Development Research, 2020,Volume: 81,Issue: 2,Page: 242-255
Authors:  Chakravarty,Harapriya;  Ju,Yaojun;  Chen,Wen Hua;  Tam,Kin Y.
Favorite |  | TC[WOS]:4 TC[Scopus]:4 | Submit date:2021/03/04
acetylcholinesterase  Alzheimer's disease  amyloid beta  butyrylcholinesterase  dual target inhibitor  isoquinolinium  pyridinium  
A dual-functional molecular strategy for in situ suppressing and visualizing of neuraminidase in aqueous solution using iridium(III) complexes Journal article
CHEMICAL COMMUNICATIONS, 2019,Volume: 55,Issue: 45,Page: 6353-6356
Authors:  Wu, C;  Wu, KJ;  Liu, JB;  Zhou, XM;  Leung, CH;  Ma, DL
Favorite |  | TC[WOS]:29 TC[Scopus]:28 | Submit date:2020/03/23
Andrographolide derivative as STAT3 inhibitor that protects acute liver damage in mice Journal article
BIOORGANIC & MEDICINAL CHEMISTRY, 2018,Volume: 26,Issue: 18,Page: 5053-5061
Authors:  Chen, Shao-Ru;  Li, Feng;  Ding, Mo-Yu;  Wang, Decai;  Zhao, Qi;  Wang, Yitao;  Zhou, Guo-Chun;  Wang, Ying
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Andrographolide  Stat3 Inhibitor  Acute Liver Damage  Inflammation  
Pinocembrin from Penthorum chinense Pursh suppresses hepatic stellate cells activation through a unified SIRT3-TGF-beta-Smad signaling pathway Journal article
TOXICOLOGY AND APPLIED PHARMACOLOGY, 2018,Volume: 341,Page: 38-50
Authors:  Zhou, Fayang;  Wang, Anqi;  Li, Dan;  Wang, Yitao;  Lin, Ligen
View | Adobe PDF | Favorite |  | TC[WOS]:17 TC[Scopus]:17 | Submit date:2018/10/30
Liver Fibrosis  Hepatic Stellate Cells  Penthorum Chinense Pursh  Pinocembrin  Sma- And Mad-related Proteins  Silent Mating Type Information Regulation 2 Homolog 3  
Discovery and preliminary SAR of 14-aryloxy-andrographolide derivatives as antibacterial agents with immunosuppressant activity Journal article
RSC ADVANCES, 2018,Volume: 8,Issue: 17,Page: 9440-9456
Authors:  Li, Feng;  Li, Xiao-Min;  Sheng, Dekuan;  Chen, Shao-Ru;  Nie, Xin;  Liu, Zhuyun;  Wang, Decai;  Zhao, Qi;  Wang, Yitao;  Wang, Ying;  Zhou, Guo-Chun
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Danshenol A inhibits TNF-α-induced expression of intercellular adhesion molecule-1 (ICAM-1) mediated by NOX4 in endothelial cells Journal article
Scientific Reports, 2017,Volume: 7,Issue: 1
Authors:  Zhao W.;  Feng H.;  Guo S.;  Han Y.;  Chen X.
Favorite |  | TC[WOS]:11 TC[Scopus]:14 | Submit date:2018/12/28