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Using Acetone/Water Binary Solvent to Enhance the Stability and Bioavailability of Spray Dried Enzalutamide/HPMC-AS Solid Dispersions Journal article
Journal of Pharmaceutical Sciences, 2021,Volume: 110,Issue: 3,Page: 1160-1171
Authors:  Zhang,Xiaoting;  Rao,Qiuhong;  Qiu,Zhenwen;  Lin,Yisheng;  Zhang,Lei;  Hu,Qingzhong;  Chen,Tingting;  Ma,Zhimin;  Gao,Hanlu;  Luo,Dandong;  Zhao,Jiaqi;  Ouyang,Defang;  Zhang,Zhenyu Jason;  Li,Qingguo
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Amorphous solid dispersion  Drug-excipient interaction  Particle size  Poorly water-soluble drug  Spray drying  
Bromodomain and extra-terminal motif (BET) inhibition is synthetic lethal with loss of SMAD4 in colorectal cancer cells via restoring the loss of MYC repression Journal article
Oncogene, 2021,Volume: 40,Issue: 5,Page: 937-950
Authors:  Shi,Changxiang;  Yang,Eun Ju;  Liu,Yifan;  Mou,Pui Kei;  Ren,Guowen;  Shim,Joong Sup
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Simultaneous blocking of the pan-RAF and S100B pathways as a synergistic therapeutic strategy against malignant melanoma Journal article
Journal of Cellular and Molecular Medicine, 2021,Volume: 25,Issue: 4,Page: 1972-1981
Authors:  Wu,Ke Jia;  Ho,Shih Hsin;  Wu,Chun;  Wang,Hui Min D.;  Ma,Dik Lung;  Leung,Chung Hang
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drug discovery  malignant melanoma  pan-RAF  S100B-p53 interaction  synergistic  
Emergence of spatio-temporal variations in chemotherapeutic drug efficacy: in-vitro and in-Silico 3D tumour spheroid studies Journal article
BMC Cancer, 2020,Volume: 20,Issue: 1
Authors:  Sheraton,M. V.;  Chiew,G. G.Y.;  Melnikov,V.;  Tan,E. Y.;  Luo,K. Q.;  Verma,N.;  Sloot,P. M.A.
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Cytotoxicity  Mitotic spindle stabilization  Pharmacodynamics  Pharmacokinetics  Reaction-diffusion model  
Interfering with S100B–effector protein interactions for cancer therapy Journal article
Drug Discovery Today, 2020,Volume: 25,Issue: 9,Page: 1754-1761
Authors:  Wu,Ke Jia;  Wang,Wanhe;  Wang,Hui Min David;  Leung,Chung Hang;  Ma,Dik Lung
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Interactions of antithrombotic herbal medicines with Western cardiovascular drugs Journal article
Pharmacological Research, 2020,Volume: 159
Authors:  Zuo,Hua Li;  Linghu,Ke Gang;  Wang,Ya Li;  Liu,Kun Meng;  Gao,Yan;  Yu,Hua;  Yang,Feng Qing;  Hu,Yuan Jia
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Antithrombotic Herbal Medicine  Butylidenephthalide (Pubchem Cid: 642376)  Cardiovascular Disease  Cryptotanshinone (Pubchem Cid: 160254)  Herb−drug Interaction  Network Pharmacology  Salvianolic ACid a (Pubchem Cid: 5281793)  Salvianolic ACid c (Pubchem Cid: 13991590)  Senkyunolide c (Pubchem Cid: 642374)  Tanshinone i (Pubchem Cid: 114917)  Tanshinone Iia (Pubchem Cid: 164676)  Western Drugs  
A Three-Way Combinatorial CRISPR Screen for Analyzing Interactions among Druggable Targets Journal article
Cell Reports, 2020,Volume: 32,Issue: 6
Authors:  Zhou,Peng;  Chan,Becky K.C.;  Wan,Yuk Kei;  Yuen,Chaya T.L.;  Choi,Gigi C.G.;  Li,Xinran;  Tong,Cindy S.W.;  Zhong,Sophia S.W.;  Sun,Jieran;  Bao,Yufan;  Mak,Silvia Y.L.;  Chow,Maggie Z.Y.;  Khaw,Jien Vei;  Leung,Suet Yi;  Zheng,Zongli;  Cheung,Lydia W.T.;  Tan,Kaeling;  Wong,Koon Ho;  Chan,H. Y.Edwin;  Wong,Alan S.L.
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Cancer  Combigem  Combination Therapy  Combinatorial Genetics  Crispr  Drug Interaction  Genetic Interaction  High-throughput Screening  Neurodegeneration  Parkinson's Disease  
PHLDA1 promotes microglia-mediated neuroinflammation via regulating K63-linked ubiquitination of TRAF6 Journal article
Brain, Behavior, and Immunity, 2020,Volume: 88,Page: 640-653
Authors:  Han,Chaojun;  Yan,Pengju;  He,Tao;  Cheng,Junjie;  Zheng,Wenhua;  Zheng,Long Tai;  Zhen,Xuechu
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Dopaminergic neuron  Microglia  Neuroinflammation  NF-κB  PHLDA1  TRAF6  Ubiquitination  
The design and development of covalent protein-protein interaction inhibitors for cancer treatment Journal article
Journal of Hematology and Oncology, 2020,Volume: 13,Issue: 1
Authors:  Cheng,Sha Sha;  Yang,Guan Jun;  Wang,Wanhe;  Leung,Chung Hang;  Ma,Dik Lung
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Cancer therapy  Covalent inhibitors  Protein-protein interaction  
The development of small-molecule inhibitors targeting CD47 Journal article
Drug Discovery Today, 2020
Authors:  Yu,Wei Bang;  Ye,Zi Han;  Chen,Xiuping;  Shi,Jia Jie;  Lu,Jin Jian
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