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Synthesis, biological evaluation and structure-activity relationship of novel dichloroacetophenones targeting pyruvate dehydrogenase kinases with potent anticancer activity Journal article
European Journal of Medicinal Chemistry, 2021,Volume: 214
Authors:  Xu,Biao;  Wang,Zhi Peng;  Liu,Qingwang;  Yang,Xiaohong;  Li,Xuemin;  Huang,Ding;  Qiu,Yanfei;  Tam,Kin Yip;  Zhang,Shao Lin;  He,Yun
Favorite |  | TC[WOS]:0 TC[Scopus]:0 | Submit date:2021/03/04
Cancer metabolism  Proliferation  Pyruvate dehydrogenase kinase  Structure-activity relationship  
Adsorbed hollow fiber immobilized tyrosinase for the screening of enzyme inhibitors from Pueraria lobata extract Journal article
Journal of Pharmaceutical and Biomedical Analysis, 2021,Volume: 193
Authors:  Zhao,Cong Peng;  Yin,Shi Jun;  Chen,Guo Ying;  Wang,Yuan;  Chen,Hua;  Zhao,Jing;  Yang,Feng Qing
Favorite |  | TC[WOS]:0 TC[Scopus]:0 | Submit date:2021/03/02
Adsorbed hollow fibers  Enzyme immobilization  Inhibitor screening  Pueraria lobata  Tyrosinase  
Anti-COVID-19 drug screening: Frontier concepts and core technologies Journal article
Chinese Medicine (United Kingdom), 2020,Volume: 15,Issue: 1
Authors:  Luo,Hua;  Zhao,Mingming;  Tan,Dechao;  Liu,Chang;  Yang,Lin;  Qiu,Ling;  Gao,Yan;  Yu,Hua
Favorite |  | TC[WOS]:3 TC[Scopus]:4 | Submit date:2021/03/02
Core Technology  Covid-19  Disease Model  Traditional Chinese Medicine  
Dissecting the mechanism of Yuzhi Zhixue granule on ovulatory dysfunctional uterine bleeding by network pharmacology and molecular docking Journal article
Chinese Medicine (United Kingdom), 2020,Volume: 15,Issue: 1
Authors:  Li,Jialin;  Luo,Hua;  Liu,Xinkui;  Zhang,Jingyuan;  Zhou,Wei;  Guo,Siyu;  Chen,Xiuping;  Liu,Yingying;  Jia,Shanshan;  Wang,Haojia;  Li,Bingbing;  Cheng,Guoliang;  Wu,Jiarui
Favorite |  | TC[WOS]:2 TC[Scopus]:1 | Submit date:2021/03/01
Mechanisms  Molecular Docking  Network pharmacology  Ovulatory Dysfunctional Uterine Bleeding  Yuzhi zhixue granule  
A pocket-escaping design to prevent the common interference with near-infrared fluorescent probes in vivo Journal article
Nature Communications, 2020,Volume: 11,Issue: 1
Authors:  Xing,Panfei;  Niu,Yiming;  Mu,Ruoyu;  Wang,Zhenzhen;  Xie,Daping;  Li,Huanling;  Dong,Lei;  Wang,Chunming
Favorite |  | TC[WOS]:1 TC[Scopus]:2 | Submit date:2021/03/02
Characterization of thrombin/factor Xa inhibitors in Rhizoma Chuanxiong through UPLC-MS-based multivariate statistical analysis Journal article
Chinese Medicine (United Kingdom), 2020,Volume: 15,Issue: 1
Authors:  Yang,Yi Yao;  Wu,Zhao Yu;  Xia,Fang Bo;  Zhang,Hao;  Wang,Xu;  Gao,Jian Li;  Yang,Feng Qing;  Wan,Jian Bo
Favorite |  | TC[WOS]:2 TC[Scopus]:3 | Submit date:2021/03/02
Chuanxiong  Enzyme inhibitor  Factor Xa  Molecular docking  Multivariate statistical analysis  Thrombin  
Identification of nagilactone E as a protein synthesis inhibitor with anticancer activity Journal article
Acta Pharmacologica Sinica, 2020,Volume: 41,Issue: 5,Page: 698-705
Authors:  Zhang,Le le;  Guo,Jing;  Jiang,Xiao ming;  Chen,Xiu ping;  Wang,Yi tao;  Li,Ao;  Lin,Li gen;  Li,Hua;  Lu,Jin jian
Favorite |  | TC[WOS]:7 TC[Scopus]:8 | Submit date:2021/03/01
Click-it  Cmap  Diterpenoids  Human Lung Cancer A549 Cell Line Xenograft  Molecular Docking  Nagilactone e  Protein Synthesis Inhibitor  Riok2  Rna-seq  
LC-MS-based multivariate statistical analysis for the screening of potential thrombin/factor Xa inhibitors from Radix Salvia Miltiorrhiza Journal article
Chinese Medicine (United Kingdom), 2020,Volume: 15,Issue: 1
Authors:  Yang,Yi Yao;  Wu,Zhao Yu;  Zhang,Hao;  Yin,Shi Jun;  Xia,Fang Bo;  Zhang,Qian;  Wan,Jian Bo;  Gao,Jian Li;  Yang,Feng Qing
Favorite |  | TC[WOS]:1 TC[Scopus]:3 | Submit date:2021/03/02
Factor Xa  Inhibitor screening  Molecular docking  Multivariate statistical analysis  Radix Salvia Miltiorrhiza  Thrombin  
Coupled genome-wide DNA methylation and transcription analysis identified rich biomarkers and drug targets in triple-negative breast cancer Journal article
Cancers, 2019,Volume: 11,Issue: 11
Authors:  Guo,Maoni;  Sinha,Siddharth;  Wang,San Ming
Favorite |  | TC[WOS]:2 TC[Scopus]:2 | Submit date:2021/03/02
DNA methylation  Gene expression  Therapeutic targets  TNBC  
Anti-inflammatory activities of Sigesbeckia glabrescens Makino: combined in vitro and in silico investigations Journal article
CHINESE MEDICINE, 2019,Volume: 14,Issue: 1
Authors:  Zhangfeng Zhong;  Qianru Zhang;  Hongxun Tao;  Wei Sang;  Liao Cui;  Wenan Qiang;  Wai San Cheang;  Yuanjia Hu;  Hua Yu;  Yitao Wang
Favorite |  | TC[WOS]:9 TC[Scopus]:9 | Submit date:2019/11/22
Sigesbeckia Glabrescens Makino  Infammation  Lipopolysaccharide  Docking  Tlr4  Nf-κb