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The emerging role of KDM5A in human cancer Journal article
Journal of Hematology and Oncology, 2021,Volume: 14,Issue: 1
Authors:  Yang,Guan Jun;  Zhu,Ming Hui;  Lu,Xin Jiang;  Liu,Yan Jun;  Lu,Jian Fei;  Leung,Chung Hang;  Ma,Dik Lung;  Chen,Jiong
Favorite |  | TC[WOS]:0 TC[Scopus]:0 | Submit date:2021/03/01
Cancer  Drug resistance  Histone methylation  Jumonji C domain  KDM5A  Targeted therapy  
Structure-Based Discovery of a Selective KDM5A Inhibitor that Exhibits Anti-Cancer Activity via Inducing Cell Cycle Arrest and Senescence in Breast Cancer Cell Lines Journal article
CANCERS, 2019,Volume: 11,Issue: 1
Authors:  Yang, GJ;  Ko, CN;  Zhong, HJ;  Leung, CH;  Ma, DL
Favorite |  | TC[WOS]:11 TC[Scopus]:10 | Submit date:2020/03/24
Cell Cycle Arrest  Kdm5a  Jumonji Domain  Histone Demethylation  Protein-protein Interaction  Virtual Screening  Breast Cancer  Cell Senescence  
Pharmacological Inhibition of LSD1 for Cancer Treatment Journal article
MOLECULES, 2018,Volume: 23,Issue: 12
Authors:  Yang, Guan-Jun;  Lei, Pui-Man;  Wong, Suk-Yu;  Ma, Dik-Lung;  Leung, Chung-Hang
Favorite |  | TC[WOS]:40 TC[Scopus]:40 | Submit date:2019/01/17
Lsd1  Demethylase  Histone  Breast Cancer  Prostate Cancer  Acute Myeloid Leukemia  Cancer Therapy  
Selective Inhibition of Lysine-Specific Demethylase 5A (KDM5A) Using a Rhodium(III) Complex for Triple-Negative Breast Cancer Therapy Journal article
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2018,Volume: 57,Issue: 40,Page: 13091-13095
Authors:  Yang, Guan-Jun;  Wang, Wanhe;  Mok, Simon Wing Fai;  Wu, Chun;  Law, Betty Yuen Kwan;  Miao, Xiang-Min;  Wu, Ke-Jia;  Zhong, Hai-Jing;  Wong, Chun-Yuen;  Wong, Vincent Kam Wai;  Ma, Dik-Lung;  Leung, Chung-Hang
Favorite |  | TC[WOS]:46 TC[Scopus]:50 | Submit date:2018/10/30
Drug Discovery  Epigenetics  Medicinal Chemistry  Triple-negative Breast Cancer  
A Rhodium(III)-Based Inhibitor of Lysine-Specific Histone Demethylase 1 as an Epigenetic Modulator in Prostate Cancer Cells Journal article
JOURNAL OF MEDICINAL CHEMISTRY, 2017,Volume: 60,Issue: 6,Page: 2597-2603
Authors:  Yang, Chao;  Wang, Wanhe;  Liang, Jia-Xin;  Li, Guodong;  Vellaisamy, Kasipandi;  Wong, Chun-Yuen;  Ma, Dik-Lung;  Leung, Chung-Hang
Favorite |  | TC[WOS]:37 TC[Scopus]:37 | Submit date:2018/10/30
JMJD-1.2/PHF8 controls axon guidance by regulating hedgehoglike signaling Journal article
Development (Cambridge), 2017,Volume: 144,Issue: 5,Page: 856-865
Authors:  Riveiro A.R.;  Mariani L.;  Malmberg E.;  Amendola P.G.;  Peltonen J.;  Wong G.;  Salcini A.E.
Favorite |  | TC[WOS]:10 TC[Scopus]:9 | Submit date:2018/12/18
Axon guidance  C. elegans  Epigenetics  Hedgehog signaling  Histone demethylase  Neuronal development  
JMJD-1.2/PHF8 controls axon guidance by regulating Hedgehog-like signaling Journal article
DEVELOPMENT, 2017,Volume: 144,Issue: 5,Page: 856-865
Authors:  Riveiro, Alba Redo;  Mariani, Luca;  Malmberg, Emily;  Amendola, Pier Giorgio;  Peltonen, Juhani;  Wong, Garry;  Salcini, Anna Elisabetta
Favorite |  | TC[WOS]:10 TC[Scopus]:9 | Submit date:2018/10/30
Epigenetics  Histone Demethylase  Neuronal Development  Axon Guidance  Hedgehog Signaling  C. Elegans  
Impaired removal of H3K4 methylation affects cell fate determination and gene transcription Journal article
Development (Cambridge), 2016,Volume: 143,Issue: 20,Page: 3751-3762
Authors:  Lussi Y.C.;  Mariani L.;  Friis C.;  Peltonen J.;  Myers T.R.;  Krag C.;  Wong G.;  Salcini A.E.
Favorite |  | TC[WOS]:7 TC[Scopus]:7 | Submit date:2018/12/18
C. Elegans  Enhancer  Gene Transcription  H3k4 Methylation  Kdm5  Rbr-2  Vpc Differentiation  
Jmjd3-mediated epigenetic regulation of inflammatory cytokine gene expression in serum amyloid A-stimulated macrophages Journal article
Cellular Signalling, 2014,Volume: 26,Issue: 9,Page: 1783-1791
Authors:  Yan Q.;  Sun L.;  Zhu Z.;  Wang L.;  Li S.;  Ye R.D.
Favorite |  | TC[WOS]:54 TC[Scopus]:54 | Submit date:2018/11/07
Histone demethylase  Jmjd3  Macrophages  Serum amyloid A  Sterile inflammation  
Effects of Radix Astragali and Radix Rehmanniae, the components of an anti-diabetic foot ulcer herbal formula, on metabolism of model CYP1A2, CYP2C9, CYP2D6, CYP2E1 and CYP3A4 probe substrates in pooled human liver microsomes and specific CYP isoforms Journal article
Phytomedicine, 2012,Volume: 19,Issue: 6,Page: 535-544
Authors:  Or P.M.Y.;  Lam F.F.Y.;  Kwan Y.W.;  Cho C.H.;  Lau C.P.;  Yu H.;  Lin G.;  Lau C.B.S.;  Fung K.P.;  Leung P.C.;  Yeung J.H.K.
Favorite |  | TC[WOS]:30 TC[Scopus]:32 | Submit date:2019/01/17
Cyp1a2  Cyp2c9  Cyp2d6  Cyp2e1  Cyp3a4  Human Liver Microsomes  Radix Astragali  Radix Rehmanniae