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Synthesis, biological evaluation and structure-activity relationship of novel dichloroacetophenones targeting pyruvate dehydrogenase kinases with potent anticancer activity Journal article
European Journal of Medicinal Chemistry, 2021,Volume: 214
Authors:  Xu,Biao;  Wang,Zhi Peng;  Liu,Qingwang;  Yang,Xiaohong;  Li,Xuemin;  Huang,Ding;  Qiu,Yanfei;  Tam,Kin Yip;  Zhang,Shao Lin;  He,Yun
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Cancer metabolism  Proliferation  Pyruvate dehydrogenase kinase  Structure-activity relationship  
Function of DHX33 in promoting Warburg effect via regulation of glycolytic genes Journal article
Journal of Cellular Physiology, 2021,Volume: 236,Issue: 2,Page: 981-996
Authors:  Peng,Cheng;  Hou,Sheng Tao;  Deng,Chu Xia;  Zhang,Yandong
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demethylation  DHX33  Gadd45a  glycolysis  RNA helicase  Warburg effect  
Simultaneous blocking of the pan-RAF and S100B pathways as a synergistic therapeutic strategy against malignant melanoma Journal article
Journal of Cellular and Molecular Medicine, 2021,Volume: 25,Issue: 4,Page: 1972-1981
Authors:  Wu,Ke Jia;  Ho,Shih Hsin;  Wu,Chun;  Wang,Hui Min D.;  Ma,Dik Lung;  Leung,Chung Hang
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drug discovery  malignant melanoma  pan-RAF  S100B-p53 interaction  synergistic  
Upregulation of amplified in breast cancer 1 contributes to pancreatic ductal adenocarcinoma progression and vulnerability to blockage of hedgehog activation Journal article
Theranostics, 2021,Volume: 11,Issue: 4,Page: 1672-1689
Authors:  Li,Licen;  Bao,Jiaolin;  Wang,Haitao;  Lei,Josh Haipeng;  Peng,Cheng;  Zeng,Jianming;  Hao,Wenhui;  Zhang,Xu;  Xu,Xiaoling;  Yu,Chundong;  Deng,Chu Xia;  Chen,Qiang
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Aib1  Ecm  Hedgehog  Mafb  Pdac  
Licochalcone A inhibits interferon-gamma-induced programmed death-ligand 1 in lung cancer cells Journal article
Phytomedicine, 2021,Volume: 80
Authors:  Yuan,Luo Wei;  Jiang,Xiao Ming;  Xu,Yu Lian;  Huang,Mu Yang;  Chen,Yu Chi;  Yu,Wei Bang;  Su,Min Xia;  Ye,Zi Han;  Chen,Xiuping;  Wang,Yitao;  Lu,Jin Jian
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Ifn-γ  Licochalcone a  Natural Products  Pd-l1  Protein Synthesis Inhibitor  Ros  
A 7-methoxybicoumarin derivative selectively inhibits BRD4 BD2 for anti-melanoma therapy Journal article
International Journal of Biological Macromolecules, 2020,Volume: 164,Page: 3204-3220
Authors:  Yang,Guan Jun;  Wang,Wanhe;  Lei,Pui Man;  Leung,Chung Hang;  Ma,Dik Lung
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BRD4  Bromodomain domain  Cell metastasis and invasion  Histone acetylation  Melanoma  Protein–protein interaction  Virtual screening  
Small Molecular Prodrug Amphiphile Self-Assembled AIE Dots for Cancer Theranostics Journal article
Frontiers in Bioengineering and Biotechnology, 2020,Volume: 8
Authors:  Yang,Xing;  Luo,Yuan;  Li,Sanpeng;  Xu,Xiuli;  Bao,Yingxia;  Yang,Jiaming;  Ouyang,Defang;  Fan,Xingxing;  Gong,Ping;  Cai,Lintao
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AIE  cancer  prodrug  self-assembly  theranostics  
Development of dual inhibitors targeting pyruvate dehydrogenase kinases and human lactate dehydrogenase A: High-throughput virtual screening, synthesis and biological validation Journal article
European Journal of Medicinal Chemistry, 2020,Volume: 203
Authors:  Xiang,Sichuan;  Huang,Ding;  He,Qiaolin;  Li,Jie;  Tam,Kin Yip;  Zhang,Shao Lin;  He,Yun
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Cancer metabolism  Cancer proliferation  Dual inhibitor  Lactate dehydrogenase A  Pyruvate dehydrogenase kinase  
LncRNA UCA1 maintains the low-tumorigenic and nonmetastatic status by stabilizing E-cadherin in primary prostate cancer cells Journal article
Molecular Carcinogenesis, 2020,Volume: 59,Issue: 10,Page: 1174-1187
Authors:  Zhao,Xian;  Wang,Yanli;  He,Jianfeng;  Deng,Rong;  Huang,Xiaojun;  Guo,Yanmin;  Li,Lian;  Xie,Ruiyu;  Yu,Jianxiu
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E-cadherin  LncRNA UCA1  MDM2  miR-296-3p  primary prostate cancer cells  
Interfering with S100B–effector protein interactions for cancer therapy Journal article
Drug Discovery Today, 2020,Volume: 25,Issue: 9,Page: 1754-1761
Authors:  Wu,Ke Jia;  Wang,Wanhe;  Wang,Hui Min David;  Leung,Chung Hang;  Ma,Dik Lung
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