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9R, the cholinesterase and amyloid beta aggregation dual inhibitor, as a multifunctional agent to improve cognitive deficit and neuropathology in the triple-transgenic Alzheimer's disease mouse model Journal article
Neuropharmacology, 2020,Volume: 181
Authors:  Ju,Yaojun;  Tam,Kin Yip
Favorite |  | TC[WOS]:1 TC[Scopus]:1 | Submit date:2021/03/04
Alzheimer's disease  Amyloid beta  Cholinesterase  Dual inhibition  Multifunction  
An Isoquinolinium Dual Inhibitor of Cholinesterases and Amyloid β Aggregation Mitigates Neuropathological Changes in a Triple-Transgenic Mouse Model of Alzheimer's Disease Journal article
ACS Chemical Neuroscience, 2020,Volume: 11,Issue: 20,Page: 3346-3357
Authors:  Ju,Yaojun;  Chakravarty,Harapriya;  Tam,Kin Yip
Favorite |  | TC[WOS]:1 TC[Scopus]:1 | Submit date:2021/03/04
Alzheimer's disease  amyloid beta  cholinesterase  dual inhibition  
Shexiang Baoxin Pill, a Traditional Chinese Herbal Formula, Rescues the Cognitive Impairments in APP/PS1 Transgenic Mice Journal article
Frontiers in Pharmacology, 2020,Volume: 11
Authors:  Hu,Wei Hui;  Mak,Shing Hung;  Zheng,Zhong Yu;  Xia,Ying Jie;  Xu,Miranda Li;  Duan,Ran;  Dong,Tina Ting Xia;  Li,Shao Ping;  Zhan,Chang Sen;  Shang,Xiao Hui;  Tsim,Karl Wah Keung
Favorite |  | TC[WOS]:1 TC[Scopus]:1 | Submit date:2021/03/01
Acetylcholinesterase  Alzheimer’s Disease  Chinese Medicine  Cognitive Enhancing Effect  Neuroprotective  Shexiang Baoxin Pill  
Dual targeting of cholinesterase and amyloid beta with pyridinium/isoquinolium derivatives Journal article
Drug Development Research, 2020,Volume: 81,Issue: 2,Page: 242-255
Authors:  Chakravarty,Harapriya;  Ju,Yaojun;  Chen,Wen Hua;  Tam,Kin Y.
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acetylcholinesterase  Alzheimer's disease  amyloid beta  butyrylcholinesterase  dual target inhibitor  isoquinolinium  pyridinium  
Fish oil protects the blood-brain barrier integrity in a mouse model of Alzheimer's disease Journal article
Chinese Medicine (United Kingdom), 2020,Volume: 15,Issue: 1
Authors:  Xie,Youna;  Yan,Lingli;  Zeng,Haitao;  Chen,Weineng;  Lu,Jia Hong;  Wan,Jian Bo;  Su,Huanxing;  Yao,Xiaoli
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Amyloid Beta  Aβ-degrading Enzymes  Neuroinflammation  Nf-κb  Omega-3 Polyunsaturated Fatty Acids  
Omega-3 polyunsaturated fatty acids promote brain-to-blood clearance of β-Amyloid in a mouse model with Alzheimer's disease Journal article
Brain, Behavior, and Immunity, 2020,Volume: 85,Page: 35-45
Authors:  Yan,Lingli;  Xie,Youna;  Satyanarayanan,Senthil Kumaran;  Zeng,Haitao;  Liu,Qiang;  Huang,Miaodan;  Ma,Yuemeng;  Wan,Jian Bo;  Yao,Xiaoli;  Su,Kuan Pin;  Su,Huanxing
Favorite |  | TC[WOS]:11 TC[Scopus]:12 | Submit date:2021/03/01
Alzheimer's Disease  Beta-amyloid  Low-density LipoProtein Receptor-related Protein 1  Neuroinflammation  Omega-3 Polyunsaturated Fatty Acids  
A small molecule transcription factor EB activator ameliorates beta-amyloid precursor protein and Tau pathology in Alzheimer's disease models Journal article
Aging Cell, 2020,Volume: 19,Issue: 2
Authors:  Song,Ju Xian;  Malampati,Sandeep;  Zeng,Yu;  Durairajan,Siva Sundara Kumar;  Yang,Chuan Bin;  Tong,Benjamin Chun Kit;  Iyaswamy,Ashok;  Shang,Wen Bin;  Sreenivasmurthy,Sravan Gopalkrishnashetty;  Zhu,Zhou;  Cheung,King Ho;  Lu,Jia Hong;  Tang,Chunzhi;  Xu,Nenggui;  Li,Min
Favorite |  | TC[WOS]:22 TC[Scopus]:21 | Submit date:2021/03/02
Alzheimer's disease  beta-amyloid  curcumin analog C1  MAPT/Tau  TFEB  
NRBF2 is a RAB7 effector required for autophagosome maturation and mediates the association of APP-CTFs with active form of RAB7 for degradation Journal article
Autophagy, 2020
Authors:  Cai,Cui Zan;  Yang,Chuanbin;  Zhuang,Xu Xu;  Yuan,Ning Ning;  Wu,Ming Yue;  Tan,Jie Qiong;  Song,Ju Xian;  Cheung,King Ho;  Su,Huanxing;  Wang,Yi Tao;  Tang,Bei Sha;  Behrends,Christian;  Durairajan,Siva Sundara Kumar;  Yue,Zhenyu;  Li,Min;  Lu,Jia Hong
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Amaturation  Autophagy  CCZ1-MON1A  NRBF2  PI3KC3/VPS34  RAB7  trafficking  
Artemisinin improved neuronal functions in Alzheimer's disease animal model 3xtg mice and neuronal cells via stimulating the ERK/CREB signaling pathway Journal article
Aging and Disease, 2020,Volume: 11,Issue: 4,Page: 801-819
Authors:  Zhao,Xia;  Li,Shuai;  Gaur,Uma;  Zheng,Wenhua
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3×Tg mice  Alzheimer's disease  Amyloid beta  Artemisinin  Cognitive behavior  SH-SY5Ycells  
Neuroprotective effects of quercetin in alzheimer’s disease Journal article
Biomolecules, 2020,Volume: 10,Issue: 1
Authors:  Khan,Haroon;  Ullah,Hammad;  Aschner,Michael;  Cheang,Wai San;  Akkol,Esra Küpeli
Favorite |  | TC[WOS]:37 TC[Scopus]:39 | Submit date:2021/03/02
Alzheimer’s Disease  Clinical Directions  Mechanistic Insights  Polyphenols  Quercetin