UM
A critical role of IFNγ in priming MSC-mediated suppression of T cell proliferation through up-regulation of B7-H1
Sheng H.3; Wang Y.3; Jin Y.1; Zhang Q.3; Zhang Y.3; Wang L.3; Shen B.3; Yin S.1; Liu W.1; Cui L.1; Li N.3
2008-08-01
Source PublicationCell Research
ISSN10010602 17487838
Volume18Issue:8Pages:846-857
AbstractBone-marrow-derived mesenchymal stem cells (MSCs) have been shown to possess immunosuppressive properties, e.g., by inhibiting T cell proliferation. Activated T cells can also enhance the immunosuppression ability of MSCs. The precise mechanisms underlying MSC-mediated immunosuppression remain largely undefined, although both cell-cell contact and soluble factors have been implicated; nor is it clear how the immunosuppressive property of MSCs is modulated by T cells. Using MSCs isolated from mouse bone marrow, we show here that interferon gamma (IFNγ), a well-known proinflammatory cytokine produced by activated T cells, plays an important role in priming the immunosuppressive property of MSCs. Mechanistically, IFNγ acts directly on MSCs and leads to up-regulation of B7-H1, an inhibitory surface molecule in these stem cells. MSCs primed by activated T cells derived from IFNγ-/- mouse exhibited dramatically reduced ability to suppress T cell proliferation, a defect that can be rescued by supplying exogenous IFNγ. Moreover, siRNA-mediated knockdown of B7-H1 in MSCs abolished immunosuppression by these cells. Taken together, our results suggest that IFNγ plays a critical role in triggering the immunosuppresion by MSCs through up-regulating B7-H1 in these cells, and provide evidence supporting the cell-cell contact mechanism in MSC-mediated immunosuppression. © 2008 IBCB, SIBS, CAS All rights reserved.
KeywordB7-H1 IFNγ Immunosuppression Mesenchymal stem cells (MSCs) Proliferation inhibition siRNA
DOI10.1038/cr.2008.80
URLView the original
Language英語
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Cited Times [WOS]:239   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionUniversity of Macau
Affiliation1.Shanghai Jiao Tong University School of Medicine
2.National Tissue Engineering Center of China
3.Shanghai Institute of Technology
Recommended Citation
GB/T 7714
Sheng H.,Wang Y.,Jin Y.,et al. A critical role of IFNγ in priming MSC-mediated suppression of T cell proliferation through up-regulation of B7-H1[J]. Cell Research,2008,18(8):846-857.
APA Sheng H..,Wang Y..,Jin Y..,Zhang Q..,Zhang Y..,...&Li N..(2008).A critical role of IFNγ in priming MSC-mediated suppression of T cell proliferation through up-regulation of B7-H1.Cell Research,18(8),846-857.
MLA Sheng H.,et al."A critical role of IFNγ in priming MSC-mediated suppression of T cell proliferation through up-regulation of B7-H1".Cell Research 18.8(2008):846-857.
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