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A Gene Regulatory Network Cooperatively Controlled by Pdx1 and Sox9 Governs Lineage Allocation of Foregut Progenitor Cells
Shih H.P.1; Seymour P.A.1; Patel N.A.1; Xie R.1; Wang A.1; Liu P.P.1; Yeo G.W.1; Magnuson M.A.4; Sander M.1
2015-10-13
Source PublicationCell Reports
ISSN22111247
Volume13Issue:2Pages:326-336
Abstract

The generation of pancreas, liver, and intestine from a common pool of progenitors in the foregut endoderm requires the establishment of organ boundaries. How dorsal foregut progenitors activate pancreatic genes and evade the intestinal lineage choice remains unclear. Here, we identify Pdx1 and Sox9 as cooperative inducers of a gene regulatory network that distinguishes the pancreatic from the intestinal lineage. Genetic studies demonstrate dual and cooperative functions for Pdx1 and Sox9 in pancreatic lineage induction and repression of the intestinal lineage choice. Pdx1 and Sox9 bind to regulatory sequences near pancreatic and intestinal differentiation genes and jointly regulate their expression, revealing direct cooperative roles for Pdx1 and Sox9 in gene activation and repression. Our study identifies Pdx1 and Sox9 as important regulators of a transcription factor network that initiates pancreatic fate and sheds light on the gene regulatory circuitry that governs the development of distinct organs from multi-lineage-competent foregut progenitors.

DOI10.1016/j.celrep.2015.08.082
URLView the original
Indexed BySCI
WOS Research AreaCell Biology
WOS SubjectCell Biology
WOS IDWOS:000362951500011
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Citation statistics
Cited Times [WOS]:37   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionFaculty of Health Sciences
Affiliation1.University of California, San Diego
2.Universidade de Macau
3.Københavns Universitet
4.Vanderbilt University
Recommended Citation
GB/T 7714
Shih H.P.,Seymour P.A.,Patel N.A.,et al. A Gene Regulatory Network Cooperatively Controlled by Pdx1 and Sox9 Governs Lineage Allocation of Foregut Progenitor Cells[J]. Cell Reports,2015,13(2):326-336.
APA Shih H.P..,Seymour P.A..,Patel N.A..,Xie R..,Wang A..,...&Sander M..(2015).A Gene Regulatory Network Cooperatively Controlled by Pdx1 and Sox9 Governs Lineage Allocation of Foregut Progenitor Cells.Cell Reports,13(2),326-336.
MLA Shih H.P.,et al."A Gene Regulatory Network Cooperatively Controlled by Pdx1 and Sox9 Governs Lineage Allocation of Foregut Progenitor Cells".Cell Reports 13.2(2015):326-336.
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