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Multifunctional PHPMA-Derived Polymer for Ratiometric pH Sensing, Fluorescence Imaging, and Magnetic Resonance Imaging
Su, Fengyu; Agarwal, Shubhangi; Pan, Tingting; Qiao, Yuan; Zhang, Liqiang; Shi, Zhengwei; Kong, Xiangxing; Day, Kevin; Chen, Meiwan; Meldrum, Deirdre; Kodibagkar, Vikram D.; Tian, Yanqing
2017-12
Source PublicationACS APPLIED MATERIALS & INTERFACES
ISSN1944-8244
Volume10Issue:2Pages:1556-1565
Abstract

In this paper, we report synthesis and characterization of a novel multimodality (MRI/fluorescence) probe for pH sensing and imaging. A multifunctional polymer was derived from poly(N-(2-hydroxypropyl)methacrylamide) (PHPMA) and integrated with a naphthalimide-based-ratiometric fluorescence probe and a gadolinium-1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid complex (Gd-DOTA complex). The polymer was characterized using UV-vis absorption spectrophotometry, fluorescence spectrofluorophotometry, magnetic resonance imaging (MRI), and confocal microscopy for optical and MRI-based pH sensing and cellular imaging. In vitro labeling of macrophage J774 and esophageal CP-A cell lines shows the polymer's ability to be internalized in the cells. The transverse relaxation time (T-2) of the polymer was observed to be pH-dependent, whereas the spin-lattice relaxation time (T-1) was not. The pH probe in the polymer shows a strong fluorescence-based ratiometric pH response with emission window changes, exhibiting blue emission under acidic conditions and green emission under basic conditions, respectively. This study provides new materials with multimodalities for pH sensing and imaging.

KeywordPolymer Ph Sensor Ratiometric Sensor Mri Fluorescence Imaging Dual-modality
DOI10.1021/acsami.7b15796
URLView the original
Indexed BySCIE
Language英語English
WOS Research AreaScience & Technology - Other Topics ; Materials Science
WOS SubjectNanoscience & Nanotechnology ; Materials Science, Multidisciplinary
WOS IDWOS:000423140400012
PublisherAMER CHEMICAL SOC
The Source to ArticleWOS
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Cited Times [WOS]:35   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionUniversity of Macau
Corresponding AuthorMeldrum, Deirdre; Kodibagkar, Vikram D.; Tian, Yanqing
Affiliation1.Arizona State Univ, Biodesign Inst, Ctr Biosignatures Discovery Automat, Tempe, AZ 85287 USA
2.Arizona State Univ, Sch Biol & Hlth Syst Engn, Tempe, AZ 85281 USA
3.Southern Univ Sci & Technol, Dept Mat Sci & Engn, Shenzhen 518055, Guangdong, Peoples R China
4.Univ Macau, Inst Chinese Med Sci, State Key Lab Qual Res Chinese Med, Ave Univ, Taipa 999078, Macau, Peoples R China
Recommended Citation
GB/T 7714
Su, Fengyu,Agarwal, Shubhangi,Pan, Tingting,et al. Multifunctional PHPMA-Derived Polymer for Ratiometric pH Sensing, Fluorescence Imaging, and Magnetic Resonance Imaging[J]. ACS APPLIED MATERIALS & INTERFACES,2017,10(2):1556-1565.
APA Su, Fengyu,Agarwal, Shubhangi,Pan, Tingting,Qiao, Yuan,Zhang, Liqiang,Shi, Zhengwei,Kong, Xiangxing,Day, Kevin,Chen, Meiwan,Meldrum, Deirdre,Kodibagkar, Vikram D.,&Tian, Yanqing.(2017).Multifunctional PHPMA-Derived Polymer for Ratiometric pH Sensing, Fluorescence Imaging, and Magnetic Resonance Imaging.ACS APPLIED MATERIALS & INTERFACES,10(2),1556-1565.
MLA Su, Fengyu,et al."Multifunctional PHPMA-Derived Polymer for Ratiometric pH Sensing, Fluorescence Imaging, and Magnetic Resonance Imaging".ACS APPLIED MATERIALS & INTERFACES 10.2(2017):1556-1565.
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