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Design and evaluation of compound metformin/glipizide elementary osmotic pump tablets
Ouyang D.2; Nie S.2; Li W.2; Guo H.2; Liu H.2; Pan W.2
2005-07-01
Source PublicationJournal of Pharmacy and Pharmacology
ISSN00223573
Volume57Issue:7Pages:817-820
Abstract

A simple elementary osmotic pump (EOP) system that could deliver metformin hydrochloride (MT) and glipizide (GZ) simultaneously for extended periods of time was developed in order to reduce the problems associated with multidrug therapy of type 2 non-insulin-dependent diabetes mellitus. In general, both highly and poorly water-soluble drugs are not good candidates for elementary osmotic delivery. However, MT is a highly soluble drug with a high dose (500mg) while GZ is a water-insoluble drug with a low dose (5mg) so it is a great challenge to pharmacists to provide satisfactory extended release of MT and GZ. In this paper sodium carbonate was used to modulate the solubility of GZ within the core and MT was not only one of the active ingredients but also the osmotic agent. The optimal EOP was found to deliver both drugs at a rate of approximately zero order for up to 10 h in pH 6.8, independent of environment media. In-vivo evaluation was performed relative to the equivalent dose of conventional MT tablet and GZ tablet by a cross-study in six Beagle dogs. The EOP had a good sustained effect in comparison with the conventional product. The prototype design of the system could be applied to other combinations of drugs used for cardiovascular diseases, diabetes, etc. © 2005 The Authors.

DOI10.1211/0022357056370
URLView the original
Indexed BySCI
Language英语
WOS Research AreaPharmacology & Pharmacy
WOS SubjectPharmacology & Pharmacy
WOS IDWOS:000230717000002
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Cited Times [WOS]:16   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Affiliation1.Wuhan General Hospital of Guangzhou Military Area Command of Chinese PLA
2.Shenyang Pharmaceutical University
3.Jiamusi University
Recommended Citation
GB/T 7714
Ouyang D.,Nie S.,Li W.,et al. Design and evaluation of compound metformin/glipizide elementary osmotic pump tablets[J]. Journal of Pharmacy and Pharmacology,2005,57(7):817-820.
APA Ouyang D.,Nie S.,Li W.,Guo H.,Liu H.,&Pan W..(2005).Design and evaluation of compound metformin/glipizide elementary osmotic pump tablets.Journal of Pharmacy and Pharmacology,57(7),817-820.
MLA Ouyang D.,et al."Design and evaluation of compound metformin/glipizide elementary osmotic pump tablets".Journal of Pharmacy and Pharmacology 57.7(2005):817-820.
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