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Suppression of ghrelin exacerbates HFCS-induced adiposity and insulin resistance
Ma X.3; Lin L.1; Yue J.1; Wu C.-S.6; Guo C.A.6; Wang R.2; Yu K.-J.2; Devaraj S.1; Murano P.6; Chen Z.4; Sun Y.1
Source PublicationInternational Journal of Molecular Sciences
ISSN14220067 16616596

High fructose corn syrup (HFCS) is widely used as sweetener in processed foods and soft drinks in the United States, largely substituting sucrose (SUC). The orexigenic hormone ghrelin promotes obesity and insulin resistance, ghrelin responds differently to HFCS and SUC ingestion. Here we investigated the roles of ghrelin in HFCS-and SUC-induced adiposity and insulin resistance. To mimic soft drinks, 10-week-old male wild-type (WT) and ghrelin knockout (Ghrelin ) mice were subjected to ad lib. regular chow diet supplemented with either water (RD), 8% HFCS (HFCS), or 10% sucrose (SUC). We found that SUC-feeding induced more robust increases in body weight and body fat than HFCS-feeding. Comparing to SUC-fed mice, HFCS-fed mice showed lower body weight but higher circulating glucose and insulin levels. Interestingly, we also found that ghrelin deletion exacerbates HFCS-induced adiposity and inflammation in adipose tissues, as well as whole-body insulin resistance. Our findings suggest that HFCS and SUC have differential effects on lipid metabolism: while sucrose promotes obesogenesis, HFCS primarily enhances inflammation and insulin resistance, and ghrelin confers protective effects for these metabolic dysfunctions.

KeywordAdipose Tissue Inflammation Adiposity Fructose Ghrelin Glucose Hfcs Insulin Resistance Sucrose
URLView the original
Indexed BySCIE
WOS Research AreaBiochemistry & Molecular Biology ; Chemistry
WOS SubjectBiochemistry & Molecular Biology ; Chemistry, Multidisciplinary
WOS IDWOS:000404581500199
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Cited Times [WOS]:10   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Corresponding AuthorMa X.; Lin L.; Yue J.; Wu C.-S.; Guo C.A.; Wang R.; Yu K.-J.; Devaraj S.; Murano P.; Chen Z.; Sun Y.
Affiliation1.Baylor College of Medicine
2.Harbin Medical University
3.Zhengzhou University
4.University of Texas Health Science Center at Houston
5.Huazhong University of Science and Technology
6.Texas A and M University
7.Universidade de Macau
Recommended Citation
GB/T 7714
Ma X.,Lin L.,Yue J.,et al. Suppression of ghrelin exacerbates HFCS-induced adiposity and insulin resistance[J]. International Journal of Molecular Sciences,2017,18(6).
APA Ma X.,Lin L.,Yue J.,Wu C.-S.,Guo C.A.,Wang R.,Yu K.-J.,Devaraj S.,Murano P.,Chen Z.,&Sun Y..(2017).Suppression of ghrelin exacerbates HFCS-induced adiposity and insulin resistance.International Journal of Molecular Sciences,18(6).
MLA Ma X.,et al."Suppression of ghrelin exacerbates HFCS-induced adiposity and insulin resistance".International Journal of Molecular Sciences 18.6(2017).
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