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Nicotinamide Promotes Cell Survival and Differentiation as Kinase Inhibitor in Human Pluripotent Stem Cells
Meng Y.1,2; Ren Z.1; Xu F.1; Zhou X.1; Song C.1; Wang V.Y.-F.2,3; Liu W.1; Lu L.4; Thomson J.A.5; Chen G.1,2
2018-12-11
Source PublicationStem Cell Reports
ISSN2213-6711
Volume11Issue:6Pages:1347-1356
Abstract

In this report, Guokai Chen and colleagues show that nicotinamide is a kinase inhibitor with multiple targets. Nicotinamide improves human pluripotent stem cell (hPSC) survival as a ROCK inhibitor, and it also induces hPSC differentiation as a casein kinase 1 inhibitor. This discovery highlights nicotinamide's regulatory function beyond its common roles in metabolism, PARP, and sirtuin pathways.

KeywordCell Differentiation Cell Survival Human Pluripotent Stem Cell Kinase Inhibitor Nicotinamide
DOI10.1016/j.stemcr.2018.10.023
URLView the original
Indexed BySCIE
Language英語English
WOS Research AreaCell Biology
WOS SubjectCell & Tissue Engineering ; Cell Biology
WOS IDWOS:000452898300008
PublisherCELL PRESS
Fulltext Access
Citation statistics
Cited Times [WOS]:28   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionFaculty of Health Sciences
Corresponding AuthorChen G.
Affiliation1.Centre of Reproduction, Development & Aging, Faculty of Health Sciences, University of Macau, Taipa, Macau, China
2.Institute of Translational Medicine, Faculty of Health Sciences, University of Macau, Taipa, Macau, China
3.Cancer Centre, Faculty of Health Sciences, University of Macau, Taipa, Macau, China
4.Bioimaging and Stem Cell Core Facility, Faculty of Health Sciences, University of Macau, Taipa, Macau, China
5.Center of Interventional Radiology, Zhuhai Precision Medical Center, Zhuhai People's Hospital, Jinan University, Zhuhai, Guangdong 519000, China
6.Regenerative Biology, Morgridge Institute for Research, Madison, WI 53715, USA
7.Department of Cell & Regenerative Biology, University of Wisconsin–Madison, Madison, WI 53706, USA
First Author AffilicationFaculty of Health Sciences
Corresponding Author AffilicationFaculty of Health Sciences
Recommended Citation
GB/T 7714
Meng Y.,Ren Z.,Xu F.,et al. Nicotinamide Promotes Cell Survival and Differentiation as Kinase Inhibitor in Human Pluripotent Stem Cells[J]. Stem Cell Reports,2018,11(6):1347-1356.
APA Meng Y.,Ren Z.,Xu F.,Zhou X.,Song C.,Wang V.Y.-F.,Liu W.,Lu L.,Thomson J.A.,&Chen G..(2018).Nicotinamide Promotes Cell Survival and Differentiation as Kinase Inhibitor in Human Pluripotent Stem Cells.Stem Cell Reports,11(6),1347-1356.
MLA Meng Y.,et al."Nicotinamide Promotes Cell Survival and Differentiation as Kinase Inhibitor in Human Pluripotent Stem Cells".Stem Cell Reports 11.6(2018):1347-1356.
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