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Paravascular pathways contribute to vasculitis and neuroinflammation after subarachnoid hemorrhage independently of glymphatic control
Luo C.4; Yao X.3; Li J.1; He B.3; Liu Q.4; Ren H.4; Liang F.3; Li M.3; Lin H.2; Peng J.2; Yuan T.F.5; Pei Z.3; Su H.4
2016-03-31
Source PublicationCell death & disease
ISSN20414889
Volume7
Abstract

Subarachnoid hemorrhage (SAH) is a devastating disease with high mortality. The mechanisms underlying its pathological complications have not been fully identified. Here, we investigate the potential involvement of the glymphatic system in the neuropathology of SAH. We demonstrate that blood components rapidly enter the paravascular space following SAH and penetrate into the perivascular parenchyma throughout the brain, causing disastrous events such as cerebral vasospasm, delayed cerebral ischemia, microcirculation dysfunction and widespread perivascular neuroinflammation. Clearance of the paravascular pathway with tissue-type plasminogen activator ameliorates the behavioral deficits and alleviates histological injury of SAH. Interestingly, AQP4(-/-) mice showed no improvements in neurological deficits and neuroinflammation at day 7 after SAH compared with WT control mice. In conclusion, our study proves that the paravascular pathway dynamically mediates the pathological complications following acute SAH independently of glymphatic control.

DOI10.1038/cddis.2016.63
URLView the original
Indexed BySCIE
Language英语
WOS Research AreaCell Biology
WOS SubjectCell Biology
WOS IDWOS:000373489000041
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Cited Times [WOS]:33   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Corresponding AuthorYuan T.F.; Pei Z.; Su H.
Affiliation1.Tangdu Hospital, Fourth Military Medical University
2.Sun Yat-Sen University, Zhongshan School of Medicine
3.Sun Yat-Sen University
4.Universidade de Macau
5.Nanjing Normal University
Recommended Citation
GB/T 7714
Luo C.,Yao X.,Li J.,et al. Paravascular pathways contribute to vasculitis and neuroinflammation after subarachnoid hemorrhage independently of glymphatic control[J]. Cell death & disease,2016,7.
APA Luo C.,Yao X.,Li J.,He B.,Liu Q.,Ren H.,Liang F.,Li M.,Lin H.,Peng J.,Yuan T.F.,Pei Z.,&Su H..(2016).Paravascular pathways contribute to vasculitis and neuroinflammation after subarachnoid hemorrhage independently of glymphatic control.Cell death & disease,7.
MLA Luo C.,et al."Paravascular pathways contribute to vasculitis and neuroinflammation after subarachnoid hemorrhage independently of glymphatic control".Cell death & disease 7(2016).
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