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Behavioral Stress Fails to Accelerate the Onset and Progression of Plaque Pathology in the Brain of a Mouse Model of Alzheimer's Disease
Yuan Q.2; Su H.4; Chau W.H.1; Toa Ng C.1; Huang J.-D.1; Wu W.1; Lin Z.-X.2
2013-01-17
Source PublicationPLoS ONE
ISSN19326203
Volume8Issue:1
Abstract

Conflicting findings exist regarding the link between environmental factors and development of Alzheimer's disease (AD) in a variety of transgenic mouse models of AD. In the present study, we investigated the effect of behavioral stress on the onset and progression of Aβ pathology in the brains of TgCRND8 mice, a transgenic mouse model of AD. One group of TgCRND8 mice was subjected to restraint stress starting at 1 month of age until they were 3 months old, while restraint stress in the second group started at 4 months of age until they were 6 months old. After 2 months of treatment, no differences in the soluble, formic acid extracted, or histologically detected Aβ deposition in the cortical and hippocampal levels were found between non-stressed and stressed mice. These results showed that restraint stress alone failed to aggravate amyloid pathology when initiated either before or after the age of amyloid plaque deposition in TgCRND8 mice, suggesting that if stress aggravated AD phenotype, it may not be via an amyloid-related mechanism in the TgCRND8 mice. These findings are indicative that plaque load per se may not be used as a significant criterion for evaluating the effect of stress on AD patients.

DOI10.1371/journal.pone.0053480
URLView the original
Indexed BySCIE
WOS Research AreaScience & Technology - Other Topics
WOS SubjectMultidisciplinary Sciences
WOS IDWOS:000314705800047
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Cited Times [WOS]:5   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Affiliation1.The University of Hong Kong Li Ka Shing Faculty of Medicine
2.Chinese University of Hong Kong
3.Jinan University
4.Universidade de Macau
Recommended Citation
GB/T 7714
Yuan Q.,Su H.,Chau W.H.,et al. Behavioral Stress Fails to Accelerate the Onset and Progression of Plaque Pathology in the Brain of a Mouse Model of Alzheimer's Disease[J]. PLoS ONE,2013,8(1).
APA Yuan Q.,Su H.,Chau W.H.,Toa Ng C.,Huang J.-D.,Wu W.,&Lin Z.-X..(2013).Behavioral Stress Fails to Accelerate the Onset and Progression of Plaque Pathology in the Brain of a Mouse Model of Alzheimer's Disease.PLoS ONE,8(1).
MLA Yuan Q.,et al."Behavioral Stress Fails to Accelerate the Onset and Progression of Plaque Pathology in the Brain of a Mouse Model of Alzheimer's Disease".PLoS ONE 8.1(2013).
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