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Contrasting neuropathology and functional recovery after spinal cord injury in developing and adult rats
Yuan Q.1; Su H.4; Chiu K.1; Wu W.1; Lin Z.-X.2
2013-08-01
Source PublicationNeuroscience Bulletin
ISSN16737067 19958218
Volume29Issue:4Pages:509-516
Abstract

Conflicting findings exist regarding the link between functional recovery and the regrowth of spinal tracts across the lesion leading to the restoration of functional contacts. In the present study, we investigated whether functional locomotor recovery was attributable to anatomical regeneration at postnatal day 1 (PN1), PN7, PN14 and in adult rats two months after transection injury at the tenth thoracic segment of the spinal cord. The Basso, Beattie, and Bresnahan scores showed that transection led to a failure of hindlimb locomotor function in PN14 and adult rats. However, PN1 and PN7 rats showed a significant level of stepping function after complete spinal cord transection. Unexpectedly, unlike the transected PN14 and adult rats in which the spinal cord underwent limited secondary degeneration and showed a scar at the lesion site, the rats transected at PN1 and PN7 showed massive secondary degeneration both anterograde and retrograde, leaving a >5-mm gap between the two stumps. Furthermore, retrograde tracing with fluorogold (FG) also showed that FG did not cross the transection site in PN1 and PN7 rats as in PN14 and adult rats, and re-transection of the cord caused no apparent loss in locomotor performance in the rats transected at PN1. Thus, these three lines of evidence strongly indicated that the functional recovery after transection in neonatal rats is independent of regrowth of spinal tracts across the lesion site. Our results support the notion that the recovery of locomotor function in developing rats may be due to intrinsic adaptations in the spinal circuitry below the lesion that control hindlimb locomotor activity rather than the regrowth of spinal tracts across the lesion. The difference in secondary degeneration between neonatal and adult rats remains to be explored.

KeywordFunctional Recovery Neonatal Rat Regeneration Spinal Cord Injury
DOI10.1007/s12264-013-1356-5
URLView the original
Indexed BySCIE
Language英語English
WOS Research AreaNeurosciences & Neurology
WOS SubjectNeurosciences
WOS IDWOS:000322393600013
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Cited Times [WOS]:14   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Affiliation1.The University of Hong Kong
2.Chinese University of Hong Kong
3.Jinan University
4.Universidade de Macau
5.The University of Hong Kong Li Ka Shing Faculty of Medicine
Recommended Citation
GB/T 7714
Yuan Q.,Su H.,Chiu K.,et al. Contrasting neuropathology and functional recovery after spinal cord injury in developing and adult rats[J]. Neuroscience Bulletin,2013,29(4):509-516.
APA Yuan Q.,Su H.,Chiu K.,Wu W.,&Lin Z.-X..(2013).Contrasting neuropathology and functional recovery after spinal cord injury in developing and adult rats.Neuroscience Bulletin,29(4),509-516.
MLA Yuan Q.,et al."Contrasting neuropathology and functional recovery after spinal cord injury in developing and adult rats".Neuroscience Bulletin 29.4(2013):509-516.
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