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Antiepileptic C21 steroids from the roots of Cynanchum otophyllum
Li X.2; Zhang M.2; Xiang C.2; Li B.-C.2; Li P.1
2015-07-03
Source PublicationJournal of Asian Natural Products Research
ISSN14772213 10286020
Volume17Issue:7Pages:724-732
Abstract

In order to discover more natural products possessing potentially antiepileptic activities, three C21 steroids, including a new one, characterized as caudatin-3-O-β-D-cymaropyranosyl-(1 → 4)-β-D-cymaropyranosyl-(1 → 4)-β-D-cymaropyranoside (1), and two known analogs, otophylloside B (2) and caudatin-3-O-β-D-oleandropyranosyl-(1 → 4)-β-D-oleandropyranosyl-(1 → 4)-β-D-cymaropyranosyl-(1 → 4)-β-D-cymaropyranoside (3), were isolated from the chloroform extract of the roots of Cynanchum otophyllum and evaluated for their antiepileptic activities by pentylenetrazole (PTZ)-induced zebrafish larval locomotor assay. The results showed that all of them had marked activities of suppressing PTZ-induced seizure behaviors in larval zebrafish at the dose of 10 μg/ml.

KeywordAntiepileptic Effect C21 Steroid Cynanchum Otophyllum Zebrafish
DOI10.1080/10286020.2014.1001380
URLView the original
Indexed BySCIE ; IC
WOS Research AreaPlant Sciences ; Chemistry ; Pharmacology & Pharmacy
WOS SubjectPlant Sciences ; Chemistry, Applied ; Chemistry, Medicinal ; Pharmacology & Pharmacy
WOS IDWOS:000359639300005
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Cited Times [WOS]:10   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Affiliation1.Universidade de Macau
2.Kunming University of Science and Technology
Recommended Citation
GB/T 7714
Li X.,Zhang M.,Xiang C.,et al. Antiepileptic C21 steroids from the roots of Cynanchum otophyllum[J]. Journal of Asian Natural Products Research,2015,17(7):724-732.
APA Li X.,Zhang M.,Xiang C.,Li B.-C.,&Li P..(2015).Antiepileptic C21 steroids from the roots of Cynanchum otophyllum.Journal of Asian Natural Products Research,17(7),724-732.
MLA Li X.,et al."Antiepileptic C21 steroids from the roots of Cynanchum otophyllum".Journal of Asian Natural Products Research 17.7(2015):724-732.
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