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PCL-F68-PCL/PLGA-PEG-PLGA mixed micelles mediated delivery of mitoxantrone for reversing multidrug resistant in breast cancer
Cai Y.4; Wang S.4; Wu M.1; Tsosie J.K.3; Xie X.2; Wan J.4; He C.4; Tian H.5; Chen X.5; Chen M.4
2016
Source PublicationRSC Advances
ISSN20462069
Volume6Issue:42Pages:35318-35327
Abstract

Mitoxantrone (MIT) is a promising candidate for cancer therapy, but the clinical application of MIT is hindered by its multidrug resistance (MDR) effect. Herein, amphiphilic poly(ϵ-caprolactone)-pluronic F68-poly(ϵ-caprolactone) (PFP) and PLGA-PEG-PLGA (PPP) polymers were designed to fabricate mixed micelles for the efficient delivery of MIT with reversed MDR effect. These mixed micelles (MIT-PFP/PPP micelles) exerted favorable particle size of 144.70 ± 10.52 nm and encapsulation efficiency of 56.69 ± 4.67%. Importantly, MIT-PFP/PPP micelles could strongly inhibit cell proliferation in MCF-7/ADR cells with the IC of 3.503 ± 0.163 μM for 24 h, which was about 7.7-fold lower than that of free MIT. The molecular mechanism of reversed MDR effect in MCF-7/ADR cells was ascribed to the downregulation of P-glycoprotein (P-gp) by MIT-PFP/PPP micelles resulting in enhanced anticancer efficacy. These findings suggest that MIT-PFP/PPP micelles have great potential for overcoming MDR effect by inhibiting the protein expression of P-gp in cancer cells.

DOI10.1039/c5ra27648a
URLView the original
Indexed BySCIE
Language英語English
WOS Research AreaChemistry
WOS SubjectChemistry, Multidisciplinary
WOS IDWOS:000374349600021
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Cited Times [WOS]:5   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Corresponding AuthorChen M.
Affiliation1.University of Florida
2.Sun Yat-Sen University
3.New Mexico Institute of Mining and Technology
4.Universidade de Macau
5.Changchun Institute of Applied Chemistry Chinese Academy of Sciences
First Author AffilicationUniversity of Macau
Corresponding Author AffilicationUniversity of Macau
Recommended Citation
GB/T 7714
Cai Y.,Wang S.,Wu M.,et al. PCL-F68-PCL/PLGA-PEG-PLGA mixed micelles mediated delivery of mitoxantrone for reversing multidrug resistant in breast cancer[J]. RSC Advances,2016,6(42):35318-35327.
APA Cai Y.,Wang S.,Wu M.,Tsosie J.K.,Xie X.,Wan J.,He C.,Tian H.,Chen X.,&Chen M..(2016).PCL-F68-PCL/PLGA-PEG-PLGA mixed micelles mediated delivery of mitoxantrone for reversing multidrug resistant in breast cancer.RSC Advances,6(42),35318-35327.
MLA Cai Y.,et al."PCL-F68-PCL/PLGA-PEG-PLGA mixed micelles mediated delivery of mitoxantrone for reversing multidrug resistant in breast cancer".RSC Advances 6.42(2016):35318-35327.
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