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Preventive effect of α-linolenic acid-rich flaxseed oil against ethanol-induced liver injury is associated with ameliorating gut-derived endotoxin-mediated inflammation in mice
Wang M.2; Zhang X.-J.2; Yan C.1; He C.2; Li P.2; Chen M.2; Su H.2; Wan J.-B.2
2016-05-01
Source PublicationJournal of Functional Foods
ISSN1756-4646
Volume23Pages:532-541
Abstract

The effects of α-linolenic acid (ALA)-rich flaxseed oil (FDO) against ethanol-induced liver injury and the probable molecular mechanisms in a mouse model of chronic-plus-single-binge ethanol feeding were evaluated. Mice were fed Lieber-DeCarli ethanol or control liquid diets with corn oil (CNO) or flaxseed oil for 10 days. On day 11, mice are gavaged with a single dose of ethanol or maltose dextrin. Ethanol exposure with CNO caused severe liver injury, inflammation and oxidative stress in liver, which were remarkably ameliorated by FDO. FDO supplementation decreased the elevation of plasma endotoxin level, which might be attributed to ameliorating ethanol-induced intestinal barrier dysfunction via upregulating the expressions of tight junction proteins. Additionally, FDO supplementation suppressed endotoxin-triggered inflammation via blocking TLR4/MyD88/NF-κB cascades in liver. These findings suggest that ALA-rich flaxseed oil may have potential to be developed as an effective agent for ethanol-induced liver injury.

KeywordEndotoxin Ethanol-induced Liver Injury Flaxseed Oil Intestinal Barrier Function Α-linolenic Acid
DOI10.1016/j.jff.2016.03.012
URLView the original
Indexed BySCIE
WOS Research AreaFood Science & Technology ; Nutrition & Dietetics
WOS SubjectFood Science & Technology ; Nutrition & Dietetics
WOS IDWOS:000376145200050
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Cited Times [WOS]:18   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Corresponding AuthorWan J.-B.
Affiliation1.Guangdong College of Pharmacy
2.Universidade de Macau
First Author AffilicationUniversity of Macau
Corresponding Author AffilicationUniversity of Macau
Recommended Citation
GB/T 7714
Wang M.,Zhang X.-J.,Yan C.,et al. Preventive effect of α-linolenic acid-rich flaxseed oil against ethanol-induced liver injury is associated with ameliorating gut-derived endotoxin-mediated inflammation in mice[J]. Journal of Functional Foods,2016,23:532-541.
APA Wang M.,Zhang X.-J.,Yan C.,He C.,Li P.,Chen M.,Su H.,&Wan J.-B..(2016).Preventive effect of α-linolenic acid-rich flaxseed oil against ethanol-induced liver injury is associated with ameliorating gut-derived endotoxin-mediated inflammation in mice.Journal of Functional Foods,23,532-541.
MLA Wang M.,et al."Preventive effect of α-linolenic acid-rich flaxseed oil against ethanol-induced liver injury is associated with ameliorating gut-derived endotoxin-mediated inflammation in mice".Journal of Functional Foods 23(2016):532-541.
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