Left Atrium Wall-mapping Application for Wall Thickness Visualisation
Sun, Jing-Yi1; Yun, Chun-Ho2,3; Mok, Greta S. P.4; Liu, Yi-Hwa5; Hung, Chung-Lieh2,6,7; Wu, Tung-Hsin1; Alaiti, Mohamad Amer8; Eck, Brendan L.8; Fares, Anas8; Bezerra, Hiram G.8

The measurement method for the LA wall thickness (WT) using cardiac computed tomography (CT) is observer dependent and cannot provide a rapid and comprehensive visualisation of the global LA WT. We aim to develop a LA wall-mapping application to display the global LA WT on a coplanar plane. The accuracy, intra-observer, and inter-observer reproducibility of the application were validated using digital/physical phantoms, and CT images of eight patients. This application on CT-based LA WT measures were further validated by testing six pig cardiac specimens. To evaluate its accuracy, the expanded maps of the physical phantom and pig LA were generated from the CT images and compared with the expanded map of the digital phantom and LA wall of pig heart. No significant differences (p > 0.05) were found between physical phantom and digital phantom as well as pig heart specimen and CT images using our application. Moreover, the analysis was based on the LA physical phantom or images of clinical patients; the results consistently demonstrated high intra-observer reproducibility (ICC > 0.9) and inter-observer reproducibility (ICC > 0.8) and showed good correlation between measures of pig heart specimen and CT data (r = 0.96, p < 0.001). The application can process and analyse the LA architecture for further visualisation and quantification.

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Indexed BySCI
WOS Research AreaScience & Technology - Other Topics
WOS SubjectMultidisciplinary Sciences
WOS IDWOS:000426825900004
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Document TypeJournal article
Affiliation1.Department of Biomedical Imaging and Radiological Sciences, National Yang Ming University, Taipei, Taiwan
2.Department of Medicine, Mackay Medical College, and Mackay Medicine Nursing and Management College, Taipei, Taiwan
3.Department of Radiology, Mackay Memorial Hospital, Taipei, Taiwan
4.Biomedical Imaging Laboratory, Department of Electrical and Computer Engineering, Faculty of Science and Technology, University of Macau, Macau, SAR, China
5.Department of Internal Medicine (Cardiology), Yale University, New Haven, CT, USA
6.Department of Internal Medicine (Cardiology), Mackay Memorial Hospital, Taipei, Taiwan
7.Institute of Clinical Medicine, and Cardiovascular Research Center, Taipei, Taiwan
8.Cardiovascular Department, University Hospitals Case Medical Center, Cleveland, OH, USA
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GB/T 7714
Sun, Jing-Yi,Yun, Chun-Ho,Mok, Greta S. P.,et al. Left Atrium Wall-mapping Application for Wall Thickness Visualisation[J]. SCIENTIFIC REPORTS,2018,8.
APA Sun, Jing-Yi.,Yun, Chun-Ho.,Mok, Greta S. P..,Liu, Yi-Hwa.,Hung, Chung-Lieh.,...&Bezerra, Hiram G..(2018).Left Atrium Wall-mapping Application for Wall Thickness Visualisation.SCIENTIFIC REPORTS,8.
MLA Sun, Jing-Yi,et al."Left Atrium Wall-mapping Application for Wall Thickness Visualisation".SCIENTIFIC REPORTS 8(2018).
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