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Identification of a rhodium(III) complex as a Wee1 inhibitor against TP53-mutated triple-negative breast cancer cells
Yang, Guan-Jun; Zhong, Hai-Jing; Ko, Chung-Nga; Wong, Suk-Yu; Vellaisamy, Kasipandi; Ye, Min; Ma, Dik-Lung; Leung, Chung-Hang
2018-03-11
Source PublicationCHEMICAL COMMUNICATIONS
ISSN1359-7345
Volume54Issue:20Pages:2463-2466
AbstractThe rhodium(III) complex 1 was identified as a potent Wee1 inhibitor in vitro and in cellulo. It decreased Wee1 activity and unscheduled mitotic entry, and induced cell damage and death in TP53-mutated triple-negative breast cancer cells. 1 represents a promising scaffold for further development of more potent metal-based Wee1 antagonists.
DOI10.1039/c7cc09384e
URLView the original
Indexed BySCI
Language英语
WOS Research AreaChemistry
WOS SubjectChemistry, Multidisciplinary
WOS IDWOS:000427544700002
PublisherROYAL SOC CHEMISTRY
The Source to ArticleWOS
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Cited Times [WOS]:20   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
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GB/T 7714
Yang, Guan-Jun,Zhong, Hai-Jing,Ko, Chung-Nga,et al. Identification of a rhodium(III) complex as a Wee1 inhibitor against TP53-mutated triple-negative breast cancer cells[J]. CHEMICAL COMMUNICATIONS,2018,54(20):2463-2466.
APA Yang, Guan-Jun.,Zhong, Hai-Jing.,Ko, Chung-Nga.,Wong, Suk-Yu.,Vellaisamy, Kasipandi.,...&Leung, Chung-Hang.(2018).Identification of a rhodium(III) complex as a Wee1 inhibitor against TP53-mutated triple-negative breast cancer cells.CHEMICAL COMMUNICATIONS,54(20),2463-2466.
MLA Yang, Guan-Jun,et al."Identification of a rhodium(III) complex as a Wee1 inhibitor against TP53-mutated triple-negative breast cancer cells".CHEMICAL COMMUNICATIONS 54.20(2018):2463-2466.
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