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Nerve growth factor protects retinal ganglion cells against injury induced by retinal ischemia-reperfusion in rats
Chen Q.1; Wang H.2; Liao S.1; Gao Y.1; Liao R.1; Little P.J.4; Xu J.5; Feng Z.-P.3; Zheng Y.1; Zheng W.1
2015
Source PublicationGrowth Factors
ISSN10292292 08977194
Volume33Issue:2Pages:149-159
AbstractIn this study, we investigated the protective effect of mouse nerve growth factor (NGF) on retinal ganglion cell (RGC) injury induced by retinal ischemia-reperfusion (RIR) in rats and explored its possible mechanisms of action. RIR caused a significant injury to RGCs and an obvious impairment of the inner retina functions, which could be seen from flash electroretinogram and flash visual evoked potential recordings. RIR also increased the expression of the apoptotic protein Bax while decreasing the expression of Bcl-2 and the phosphorylation of protein kinase B (Akt) in RGCs. Preinjection (i.m.) of NGF for 22 d reversed the injury induced by RIR and ameliorated the inner retina functions. NGF also reduced the expression of Bax and reversed the reduction of Bcl-2 and the phosphorylated Akt induced by RIR. These results indicate that NGF produces a neuroprotective effect on RGCs against RIR injury and the protective effect of NGF is mainly mediated by the PI-3K/Akt signaling pathway.
KeywordNerve growth factor PI-3K/Akt signaling pathway Retinal ganglion cells Retinal ischemia-reperfusion
DOI10.3109/08977194.2015.1010642
URLView the original
Language英語English
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Cited Times [WOS]:15   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionUniversity of Macau
Affiliation1.Zhongshan Ophthalmic Center
2.Universidade de Macau
3.University of Toronto Faculty of Medicine
4.RMIT University
5.Southern Medical University
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GB/T 7714
Chen Q.,Wang H.,Liao S.,et al. Nerve growth factor protects retinal ganglion cells against injury induced by retinal ischemia-reperfusion in rats[J]. Growth Factors,2015,33(2):149-159.
APA Chen Q.,Wang H.,Liao S.,Gao Y.,Liao R.,Little P.J.,Xu J.,Feng Z.-P.,Zheng Y.,&Zheng W..(2015).Nerve growth factor protects retinal ganglion cells against injury induced by retinal ischemia-reperfusion in rats.Growth Factors,33(2),149-159.
MLA Chen Q.,et al."Nerve growth factor protects retinal ganglion cells against injury induced by retinal ischemia-reperfusion in rats".Growth Factors 33.2(2015):149-159.
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