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Interpolated average CT for cardiac PET/CT attenuation correction
Mok G.S.P.1; Ho C.Y.T.1; Yang B.-H.2,3; Wu T.-H.2
2016-10-01
Source PublicationJournal of Nuclear Cardiology
ISSN15326551 10713581
Volume23Issue:5Pages:1072-1079
Abstract

Background: Previously, we proposed interpolated averaged CT (IACT) for improved attenuation correction (AC) in thoracic PET/CT. This study aims to evaluate its feasibility and effectiveness on cardiac PET/CT. Methods: We simulated F-FDG distribution using the XCAT phantom with normal and abnormal cardiac uptake. Average activity and attenuation maps represented static PET and respiration average CT (ACT), respectively, while the attenuation maps of end-inspiration/expiration represented 2 helical CTs (HCT). IACT was obtained by averaging the 2 extreme phases and the interpolated phases generated between them. Later, we recruited 4 patients who were scanned 1 hr post 315-428 MBq F-FDG injection. Simulated and clinical PET sinograms were reconstructed with AC using (1) HCT, (2) IACT, and (3) ACT. Polar plots and the 17-segment plots were analyzed. Two regions-of-interest were drawn on lesion and background area to obtain the intensity ratio (IR). Results: Polar plots of PET were more similar to PET in both simulation and clinical data. Artifacts were observed in various segments in PET. IR differences of HCT as compared to the phantom were up to ~20%. Conclusions: IACT-AC reduced respiratory artifacts and improved PET/CT matching similarly to ACT-AC. It is a promising low-dose alternate of ACT for cardiac PET/CT.

KeywordAttenuation Correction Cardiac Imaging Pet/ct Respiratory Artifacts
DOI10.1007/s12350-015-0140-5
URLView the original
Indexed BySCIE
Language英语
WOS Research AreaCardiovascular System & Cardiology ; Radiology, Nuclear Medicine & Medical Imaging
WOS SubjectCardiac & Cardiovascular Systems ; Radiology, Nuclear Medicine & Medical Imaging
WOS IDWOS:000384555800021
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Cited Times [WOS]:5   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionFaculty of Health Sciences
Corresponding AuthorMok G.S.P.
Affiliation1.Biomedical Imaging Laboratory, Department of Electrical and Computer Engineering, Faculty of Science and Technology, University of Macau, Macau, SAR, China
2.Department of Biomedical Imaging and Radiological Sciences, National Yang Ming University, Taipei, Taiwan
3.Department of Nuclear Medicine, Taipei Veterans General Hospital, Taipei, Taiwan
First Author AffilicationFaculty of Science and Technology
Corresponding Author AffilicationFaculty of Science and Technology
Recommended Citation
GB/T 7714
Mok G.S.P.,Ho C.Y.T.,Yang B.-H.,et al. Interpolated average CT for cardiac PET/CT attenuation correction[J]. Journal of Nuclear Cardiology,2016,23(5):1072-1079.
APA Mok G.S.P.,Ho C.Y.T.,Yang B.-H.,&Wu T.-H..(2016).Interpolated average CT for cardiac PET/CT attenuation correction.Journal of Nuclear Cardiology,23(5),1072-1079.
MLA Mok G.S.P.,et al."Interpolated average CT for cardiac PET/CT attenuation correction".Journal of Nuclear Cardiology 23.5(2016):1072-1079.
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