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Adjunctive benzodiazepine treatment of hospitalized schizophrenia patients in Asia from 2001 to 2008
Tor P.-C.14; Ng T.P.14; Yong K.-H.11; Sim K.11; Xiang Y.-T.3; Wang C.-Y.3; Lee E.H.M.9; Fujii S.1; Yang S.-Y.5; Chong M.-Y.8; Ungvari G.S.7; Si T.13; He Y.L.15; Chung E.K.6; Chee K.-Y.2; Trivedi J.10; Udomratn P.17; Shinfuku N.16; Kua E.H.14; Tan C.H.14; Sartorius N.12; Baldessarini R.J.4
Source PublicationInternational Journal of Neuropsychopharmacology
ISSN14611457 14695111
AbstractBenzodiazepines are commonly prescribed to patients with schizophrenia in many countries, but as little is known about such treatment in Asia, we evaluated their adjunctive use for 6761 in-patients diagnosed with schizophrenia in nine Asian countries using a cross-sectional study design in 2001, 2004 and 2008. Multivariate logistic regression and multivariate linear regression analyses were performed to assess predictors of benzodiazepine use and dose, respectively. Overall, 54% of the patients received adjunctive benzodiazepines at an average daily dose equivalent to 30.3 mg diazepam, with minor changes over the years sampled. Benzodiazepine use was highest in Taiwan and Japan, lowest in Thailand and China, and was associated with fewer years ill, presence of delusions (OR 1.24), hallucinations (OR 1.22), disorganized speech (OR 1.17), social or occupational dysfunction (OR 1.16), and use of mood stabilizers (OR 3.15), antiparkinsonian (OR 1.79) or antidepressant drugs (OR 1.33), and lower doses of antipsychotics (all p=0.016 to <0.001). Benzodiazepine doses were highest in Taiwan and China, lowest in Korea and Singapore; higher doses were associated with being young, male, physically aggressive, receiving mood stabilizers, and having electroconvulsive treatment (all p=0.019 to <0.001). Benzodiazepine use was associated with neurological and systemic adverse effects. In conclusion, benzodiazepine use was common in Asian patients with schizophrenia. Predictors of benzodiazepine use and dose differed in this population. Critical clinical guidelines should be developed specifically for Asian countries to address sound practices in regard to use of benzodiazepines for psychotic disorders. © 2011 CINP.
KeywordAdverse effects antipsychotics Asian benzodiazepines polytherapy schizophrenia
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Document TypeJournal article
CollectionFaculty of Health Sciences
Affiliation1.Hyogo Institute for Traumatic Stress
2.Kuala Lumpur Hospital
3.Beijing An Ding Hospital, Capital Medical University
4.McLean Hospital
5.Taipei City Hospital Taiwan
6.Seoul National University
7.University of Western Australia
8.Chang Gung University
9.Chinese University of Hong Kong
10.Chhatrapati Shahuji Maharaj Medical University
11.Singapore Institute of Mental Health
12.Université de Genève
13.Peking University
14.National University Hospital, Singapore
15.Shanghai Mental Health Center
16.Seinan Gakuin University
17.Prince of Songkla University
Recommended Citation
GB/T 7714
Tor P.-C.,Ng T.P.,Yong K.-H.,et al. Adjunctive benzodiazepine treatment of hospitalized schizophrenia patients in Asia from 2001 to 2008[J]. International Journal of Neuropsychopharmacology,2011,14(6):735-745.
APA Tor P.-C..,Ng T.P..,Yong K.-H..,Sim K..,Xiang Y.-T..,Wang C.-Y..,Lee E.H.M..,Fujii S..,Yang S.-Y..,Chong M.-Y..,Ungvari G.S..,Si T..,He Y.L..,Chung E.K..,Chee K.-Y..,Trivedi J..,Udomratn P..,Shinfuku N..,Kua E.H..,...&Baldessarini R.J..(2011).Adjunctive benzodiazepine treatment of hospitalized schizophrenia patients in Asia from 2001 to 2008.International Journal of Neuropsychopharmacology,14(6),735-745.
MLA Tor P.-C.,et al."Adjunctive benzodiazepine treatment of hospitalized schizophrenia patients in Asia from 2001 to 2008".International Journal of Neuropsychopharmacology 14.6(2011):735-745.
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